{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:45:27Z","timestamp":1788911127766,"version":"build-2803163510"},"reference-count":293,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Sciences"],"abstract":"<jats:p>Sleep complaints can be both common and complex in the older patient. Their consideration is an important aspect of holistic care, and may have an impact on quality of life, mortality, falls and disease risk. Sleep assessment should form part of the comprehensive geriatric assessment. If sleep disturbance is brought to light, consideration of sleep disorders, co-morbidity and medication management should form part of a multifaceted approach. Appreciation of the bi-directional relationship and complex interplay between co-morbidity and sleep in older patients is an important element of patient care. This article provides a brief overview of sleep disturbance and sleep disorders in older patients, in addition to their association with specific co-morbidities including depression, heart failure, respiratory disorders, gastro-oesophageal reflux disease, nocturia, pain, Parkinson\u2019s disease, dementia, polypharmacy and falls. A potential systematic multidomain approach to assessment and management is outlined, with an emphasis on non-pharmacological treatment where possible.<\/jats:p>","DOI":"10.3390\/medsci9020031","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T02:32:43Z","timestamp":1621823563000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Sleep Disturbance, Sleep Disorders and Co-Morbidities in the Care of the Older Person"],"prefix":"10.3390","volume":"9","author":[{"given":"Christine E.","family":"Mc Carthy","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, University Hospital Galway, Galway, Ireland"},{"name":"HRB-Clinical Research Facility, National University of Ireland, Galway, Co., Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-psych-010213-115205","article-title":"Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective","volume":"66","author":"Irwin","year":"2015","journal-title":"Annu. Rev. Psychol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Redline, S., and Berger, N.A. (2014). Effects of Sleep Deficiency on Hormones, Cytokines, and Metabolism. Impact of Sleep and Sleep Disturbances on Obesity and Cancer, Springer.","DOI":"10.1007\/978-1-4614-9527-7"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/sleep\/27.7.1255","article-title":"Meta-Analysis of Quantitative Sleep Parameters from Childhood to Old Age in Healthy Individuals: Developing Normative Sleep Values Across the Human Lifespan","volume":"27","author":"Ohayon","year":"2004","journal-title":"Sleep"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jsmc.2017.09.002","article-title":"Insomnia in the Older Adult","volume":"13","author":"Brewster","year":"2018","journal-title":"Sleep Med. Clin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cnur.2017.04.009","article-title":"Impaired Sleep","volume":"52","author":"Dean","year":"2017","journal-title":"Nurs. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e008119","DOI":"10.1136\/bmjopen-2015-008119","article-title":"Sleep Duration and Mortality in the Elderly: A Systematic Review with Meta-Analysis","volume":"6","author":"Schaan","year":"2016","journal-title":"BMJ Open"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.5665\/sleep.6098","article-title":"Onset of Impaired Sleep and Cardiovascular Disease Risk Factors: A Longitudinal Study","volume":"39","author":"Clark","year":"2016","journal-title":"Sleep"},{"key":"ref_8","first-page":"889","article-title":"Prevalence of Sleep Problems and Quality of Life in an Older Population","volume":"25","author":"Schubert","year":"2002","journal-title":"Sleep"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1177\/0733464816681149","article-title":"Poor Sleep and Risk of Falls in Community-Dwelling Older Adults: A Systematic Review","volume":"37","author":"Min","year":"2018","journal-title":"J. Appl. Gerontol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/sleep\/18.6.425","article-title":"Sleep Complaints Among Elderly Persons: An Epidemiologic Study of Three Communities","volume":"18","author":"Foley","year":"1995","journal-title":"Sleep"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/JGP.0b013e3181557b69","article-title":"Sleeping Well, Aging Well: A Descriptive and Cross-Sectional Study of Sleep in \u201cSuccessful Agers\u201d 75 and Older","volume":"16","author":"Driscoll","year":"2008","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.sleep.2013.11.791","article-title":"Effects of Aging on Sleep Structure throughout Adulthood: A Population-Based Study","volume":"15","author":"Moraes","year":"2014","journal-title":"Sleep Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsmc.2017.09.001","article-title":"Sleep in Normal Aging","volume":"13","author":"Li","year":"2018","journal-title":"Sleep Med. Clin."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neubiorev.2019.01.013","article-title":"Roles of Aging in Sleep","volume":"98","author":"Zhong","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_15","unstructured":"Yan, S., and Wang, W. (2016). The Effect of Lens Aging and Cataract Surgery on Circadian Rhythm. Int. J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Esquiva, G., Lax, P., P\u00e9rez-Santonja, J.J., Garc\u00eda-Fern\u00e1ndez, J.M., and Cuenca, N. (2017). Loss of Melanopsin-Expressing Ganglion Cell Subtypes and Dendritic Degeneration in the Aging Human Retina. Front. Aging Neurosci., 9.","DOI":"10.3389\/fnagi.2017.00079"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"101331","DOI":"10.1016\/j.smrv.2020.101331","article-title":"Sleep Disturbances in Bereavement: A Systematic Review","volume":"53","author":"Lancel","year":"2020","journal-title":"Sleep Med. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1136\/bmj.316.7142.1452","article-title":"Coping with Loss: Loss in Late Life","volume":"316","author":"Pitt","year":"1998","journal-title":"BMJ"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/1054773816673175","article-title":"Sleep Among Long-Term Care Residents in China: A Narrative Review of Literature","volume":"27","author":"Li","year":"2018","journal-title":"Clin. Nurs. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/15402002.2015.1007990","article-title":"Daily Social Contact in Relation to Sleep: The Role of Age","volume":"14","author":"Tighe","year":"2016","journal-title":"Behav. Sleep Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.sleep.2012.02.009","article-title":"Prevalence and Correlates for Sleep Complaints in Older Adults in Low and Middle Income Countries: A 10\/66 Dementia Research Group Study","volume":"13","author":"Mazzotti","year":"2012","journal-title":"Sleep Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Li, J., and Gooneratne, N.S. (2019). Sleep and Health in Older Adults. Sleep and Health, Elsevier.","DOI":"10.1016\/B978-0-12-815373-4.00004-6"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jsmc.2017.09.003","article-title":"Apnea in Older Adults","volume":"13","author":"Chowdhuri","year":"2018","journal-title":"Sleep Med. Clin."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11910-004-0031-7","article-title":"Review of Rapid Eye Movement Behavior Sleep Disorders","volume":"4","author":"Abad","year":"2004","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/sleep\/30.2.213","article-title":"Comorbidity of Chronic Insomnia with Medical Problems","volume":"30","author":"Taylor","year":"2007","journal-title":"Sleep"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jpsychores.2004.02.010","article-title":"Sleep Disturbances and Chronic Disease in Older Adults","volume":"56","author":"Foley","year":"2004","journal-title":"J. Psychosom. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1532-5415.2009.02220.x","article-title":"Evidence-Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons: Assessment and Management of Sleep Disorders in Older Persons","volume":"57","author":"Bloom","year":"2009","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/psyg.12319","article-title":"Sleep Disorders in the Elderly: A Growing Challenge: Sleep in Elderly","volume":"18","author":"Gulia","year":"2018","journal-title":"Psychogeriatrics"},{"key":"ref_29","unstructured":"American Academy of Sleep Medicine (2014). The International Classification of Sleep Disorders, American Academy of Sleep Medicine. [3rd ed.]. (ICSD-3)."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/sleep\/26.6.754","article-title":"Practice Parameters for Using Polysomnography to Evaluate Insomnia: An Update","volume":"26","author":"Littner","year":"2003","journal-title":"Sleep"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/07317115.2017.1408734","article-title":"Measuring Sleep in Vulnerable Older Adults: A Comparison of Subjective and Objective Sleep Measures","volume":"41","author":"Hughes","year":"2018","journal-title":"Clin. Gerontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.5665\/sleep.2956","article-title":"Polysomnographic and Subjective Sleep Markers of Mild Cognitive Impairment","volume":"36","author":"Atienza","year":"2013","journal-title":"Sleep"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11940-016-0424-3","article-title":"Treatment of Sleep Disorders in Dementia","volume":"18","author":"Ooms","year":"2016","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/fampra\/cmx122","article-title":"Sleep Hygiene Education as a Treatment of Insomnia: A Systematic Review and Meta-Analysis","volume":"35","author":"Chung","year":"2018","journal-title":"Fam. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1087-0792(03)00026-1","article-title":"A Systematic Review of Non-Pharmacological Therapies for Sleep Problems in Later Life","volume":"8","author":"Montgomery","year":"2004","journal-title":"Sleep Med. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1037\/0278-6133.25.1.3","article-title":"Comparative Meta-Analysis of Behavioral Interventions for Insomnia and Their Efficacy in Middle-Aged Adults and in Older Adults 55+ Years of Age","volume":"25","author":"Irwin","year":"2006","journal-title":"Health Psychol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1001\/jama.295.24.2851","article-title":"Cognitive Behavioral Therapy vs Zopiclone for Treatment of Chronic Primary Insomnia in Older Adults: A Randomized Controlled Trial","volume":"295","author":"Sivertsen","year":"2006","journal-title":"JAMA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s11606-018-4390-1","article-title":"Increasing Access to and Utilization of Cognitive Behavioral Therapy for Insomnia (CBT-I): A Narrative Review","volume":"33","author":"Koffel","year":"2018","journal-title":"J. Gen. Intern. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Salvemini, A., D\u2019Onofrio, G., Ciccone, F., Greco, A., Tullio, A., Addante, F., Sancarlo, D., Vendemiale, G., Serviddio, G., and Ricciardi, F. (2019). Insomnia and Information and Communication Technologies (ICT) in Elderly People: A Systematic Review. Med. Sci., 7.","DOI":"10.3390\/medsci7060070"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.smrv.2015.08.009","article-title":"The Effects of Light Therapy on Sleep Problems: A Systematic Review and Meta-Analysis","volume":"29","author":"Meijer","year":"2016","journal-title":"Sleep Med. Rev."},{"key":"ref_41","first-page":"129","article-title":"Treatment of Insomnia in Elderly Patients","volume":"2","author":"Richter","year":"2020","journal-title":"J. Reatt. Ther. Dev. Divers."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1136\/bmj.38623.768588.47","article-title":"Sedative Hypnotics in Older People with Insomnia: Meta-Analysis of Risks and Benefits","volume":"331","author":"Glass","year":"2005","journal-title":"BMJ"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3961\/jpmph.2012.45.4.219","article-title":"Zolpidem Use and Risk of Fracture in Elderly Insomnia Patients","volume":"45","author":"Kang","year":"2012","journal-title":"J. Prev. Med. Public Health"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1136\/jech-2011-200314","article-title":"Benzodiazepine Use and Risk of Dementia: Evidence from the Caerphilly Prospective Study (CaPS)","volume":"66","author":"Gallacher","year":"2012","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.37901\/jcphp18-00022","article-title":"Association between Sleep Medications and Falls and Fall-Related Worries in Community-Dwelling Older Adults in the United States","volume":"66","author":"Nguyen","year":"2020","journal-title":"J. Contemp. Pharm. Pract."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3685789","article-title":"The Association between Sleep Problems, Sleep Medication Use, and Falls in Community-Dwelling Older Adults: Results from the Health and Retirement Study 2010","volume":"2016","author":"Min","year":"2016","journal-title":"J. Aging Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"918","DOI":"10.12688\/f1000research.8729.3","article-title":"Hypnotic Drug Risks of Mortality, Infection, Depression, and Cancer: But Lack of Benefit","volume":"5","author":"Kripke","year":"2018","journal-title":"F1000Research"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"125","DOI":"10.7326\/M15-2175","article-title":"Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline from the American College of Physicians","volume":"165","author":"Qaseem","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s40266-018-0569-8","article-title":"Insomnia in Elderly Patients: Recommendations for Pharmacological Management","volume":"35","author":"Abad","year":"2018","journal-title":"Drugs Aging"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/YIC.0b013e32832e9b08","article-title":"The Effect of Prolonged-Release Melatonin on Sleep Measures and Psychomotor Performance in Elderly Patients with Insomnia","volume":"24","author":"Luthringer","year":"2009","journal-title":"Int. Clin. Psychopharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1365-2869.2007.00613.x","article-title":"Prolonged-Release Melatonin Improves Sleep Quality and Morning Alertness in Insomnia Patients Aged 55 Years and Older and Has No Withdrawal Effects","volume":"16","author":"Lemoine","year":"2007","journal-title":"J. Sleep Res."},{"key":"ref_52","first-page":"337","article-title":"Controlled release melatonin (Circadin) in the treatment of insomnia in older patients: Efficacy and safety in patients with history of use and non-use of hypnotic drugs","volume":"148","author":"Zisapel","year":"2009","journal-title":"Harefuah"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/imj.13606","article-title":"Sleep Disordered Breathing: Management Update","volume":"47","author":"Mohammadieh","year":"2017","journal-title":"Intern. Med. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1183\/20734735.003216","article-title":"Sleep Disordered Breathing at the Extremes of Age: The Elderly","volume":"12","author":"McMillan","year":"2016","journal-title":"Breathe"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4065\/mcp.2010.0810","article-title":"Updates on Definition, Consequences, and Management of Obstructive Sleep Apnea","volume":"86","author":"Park","year":"2011","journal-title":"Mayo Clin. Proc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1001\/jama.291.16.2013","article-title":"Risk Factors for Obstructive Sleep Apnea in Adults","volume":"291","author":"Young","year":"2004","journal-title":"JAMA"},{"key":"ref_57","first-page":"930","article-title":"Central Sleep Apnoea-a Clinical Review","volume":"7","author":"Muza","year":"2015","journal-title":"J. Thorac. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.5665\/sleep.3844","article-title":"Obstructive Sleep Apnea in Older Adults Is a Distinctly Different Physiological Phenotype","volume":"37","author":"Edwards","year":"2014","journal-title":"Sleep"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000218143","article-title":"Effects of Age on the Clinical Features of Men with Obstructive Sleep Apnea Syndrome","volume":"78","author":"Chung","year":"2009","journal-title":"Respiration"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1183\/09031936.00177411","article-title":"The Impact of Ageing and Sex on the Association between Sleepiness and Sleep Disordered Breathing","volume":"40","author":"Morrell","year":"2012","journal-title":"Eur. Respir. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.smrv.2006.08.005","article-title":"Sleep Apnea in the Elderly: A Specific Entity?","volume":"11","author":"Launois","year":"2007","journal-title":"Sleep Med. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5001\/omj.2018.36","article-title":"Screening Questionnaires for Obstructive Sleep Apnea: An Updated Systematic Review","volume":"33","author":"Amra","year":"2018","journal-title":"Oman Med. J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"E25","DOI":"10.1503\/cmaj.130952","article-title":"Diagnostic Accuracy of Level 3 Portable Sleep Tests versus Level 1 Polysomnography for Sleep-Disordered Breathing: A Systematic Review and Meta-Analysis","volume":"186","author":"Topfer","year":"2014","journal-title":"Can. Med. Assoc. J."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Morales, C.R., Hurley, S., Wick, L.C., Staley, B., Pack, F.M., Gooneratne, N.S., Maislin, G., Pack, A., and Gurubhagavatula, I. (2012). In-Home, Self-Assembled Sleep Studies Are Useful in Diagnosing Sleep Apnea in the Elderly. Sleep.","DOI":"10.5665\/sleep.2196"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s11325-012-0742-y","article-title":"Is Portable Monitoring for Diagnosing Obstructive Sleep Apnea Syndrome Suitable in Elderly Population?","volume":"17","author":"Polese","year":"2013","journal-title":"Sleep Breath"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1161\/01.STR.0000236560.15735.0f","article-title":"Severe Sleep Apnea and Risk of Ischemic Stroke in the Elderly","volume":"37","author":"Munoz","year":"2006","journal-title":"Stroke"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1600-0404.2011.01625.x","article-title":"Central Sleep Apnea Is Associated with Increased Risk of Ischemic Stroke in the Elderly: Central Sleep Apnea and Risk of Stroke in the Elderly","volume":"126","author":"Rubio","year":"2012","journal-title":"Acta Neurol. Scand."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jamda.2012.07.003","article-title":"Occult Nighttime Hypertension in Daytime Normotensive Older Patients With Obstructive Sleep Apnea","volume":"13","author":"Onen","year":"2012","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1034\/j.1600-0420.2000.078006638.x","article-title":"High Prevalence of Sleep-Disordered Breathing in Patients with Primary Open-Angle Glaucoma","volume":"78","author":"Onen","year":"2000","journal-title":"Acta Ophthalmol. Scand."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jamda.2008.10.008","article-title":"Falling-Asleep\u2013Related Injured Falls in the Elderly","volume":"10","author":"Onen","year":"2009","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/sleep\/34.4.435","article-title":"Sleep Disordered Breathing with Excessive Daytime Sleepiness Is a Risk Factor for Mortality in Older Adults","volume":"34","author":"Gooneratne","year":"2011","journal-title":"Sleep"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Virgine Dauphinot, H.O.S. (2013). Morbidity and Predicted Mortality in Older Adults with Central Sleep Apnea. J. Sleep Disord. Ther., 2.","DOI":"10.4172\/2167-0277.1000146"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jamaneurol.2017.2180","article-title":"Association of Sleep-Disordered Breathing with Cognitive Function and Risk of Cognitive Impairment: A Systematic Review and Meta-Analysis","volume":"74","author":"Leng","year":"2017","journal-title":"JAMA Neurol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1183\/13993003.01975-2015","article-title":"Principles of Practice Parameters for the Treatment of Sleep Disordered Breathing in the Elderly and Frail Elderly: The Consensus of the International Geriatric Sleep Medicine Task Force","volume":"48","author":"Netzer","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1111\/j.1532-5415.2008.01934.x","article-title":"Cognitive Effects of Treating Obstructive Sleep Apnea in Alzheimer\u2019s Disease: A Randomized Controlled Study: Effect of Treating Osa on Cognition in Ad","volume":"56","author":"Palmer","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1378\/chest.130.6.1772","article-title":"Normalization of Memory Performance and Positive Airway Pressure Adherence in Memory-Impaired Patients with Obstructive Sleep Apnea","volume":"130","author":"Zimmerman","year":"2006","journal-title":"Chest"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5664\/jcsm.27538","article-title":"Sustained Use of CPAP Slows Deterioration of Cognition, Sleep, and Mood in Patients with Alzheimer\u2019s Disease and Obstructive Sleep Apnea: A Preliminary Study","volume":"5","author":"Cooke","year":"2009","journal-title":"J. Clin. Sleep Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00380-013-0451-x","article-title":"Continuous Positive Airway Pressure Treatment Improves Cardiovascular Outcomes in Elderly Patients with Cardiovascular Disease and Obstructive Sleep Apnea","volume":"30","author":"Nishihata","year":"2015","journal-title":"Heart Vessel."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.5665\/SLEEP.1254","article-title":"Continuous Positive Airway Pressure: Evaluation of a Novel Therapy for Patients with Acute Ischemic Stroke","volume":"34","author":"Bravata","year":"2011","journal-title":"Sleep"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1378\/chest.128.4.2123","article-title":"Continuous Positive Airway Pressure Treatment in Sleep Apnea Prevents New Vascular Events after Ischemic Stroke","volume":"128","year":"2005","journal-title":"Chest"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1183\/09031936.00064214","article-title":"Obstructive Sleep Apnoea in the Elderly: Role of Continuous Positive Airway Pressure Treatment","volume":"46","author":"Chiner","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"565","DOI":"10.6061\/clinics\/2012(06)04","article-title":"Oxidative Stress and Quality of Life in Elderly Patients with Obstructive Sleep Apnea Syndrome: Are There Differences after Six Months of Continuous Positive Airway Pressure Treatment?","volume":"67","author":"Yagihara","year":"2012","journal-title":"Clinics"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.smrv.2011.01.003","article-title":"A Systematic Review of CPAP Adherence across Age Groups: Clinical and Empiric Insights for Developing CPAP Adherence Interventions","volume":"15","author":"Sawyer","year":"2011","journal-title":"Sleep Med. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/01.JGP.0000192484.12684.cd","article-title":"Adherence to Continuous Positive Airway Pressure Treatment in Patients with Alzheimer Disease and Obstructive Sleep Apnea","volume":"14","author":"Ayalon","year":"2006","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1212\/WNL.0000000000003388","article-title":"Practice Guideline Summary: Treatment of Restless Legs Syndrome in Adults: Table: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology","volume":"87","author":"Winkelman","year":"2016","journal-title":"Neurology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fnagi.2017.00171","article-title":"Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management","volume":"9","author":"Guo","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1468-1331.2007.01862.x","article-title":"A Single Question for the Rapid Screening of Restless Legs Syndrome in the Neurological Clinical Practice","volume":"14","author":"Ferri","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.sleep.2014.03.025","article-title":"Restless Legs Syndrome\/Willis\u2013Ekbom Disease Diagnostic Criteria: Updated International Restless Legs Syndrome Study Group (IRLSSG) Consensus Criteria\u2014History, Rationale, Description, and Significance","volume":"15","author":"Allen","year":"2014","journal-title":"Sleep Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.smrv.2011.05.002","article-title":"Epidemiology of Restless Legs Syndrome: A Synthesis of the Literature","volume":"16","author":"Ohayon","year":"2012","journal-title":"Sleep Med. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1007\/s10072-007-0737-9","article-title":"Aetiopathogenesis of Restless Legs Syndrome","volume":"28","author":"Zucconi","year":"2007","journal-title":"Neurol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.amjmed.2006.11.003","article-title":"Controversies and Challenges in Defining the Etiology and Pathophysiology of Restless Legs Syndrome","volume":"120","author":"Allen","year":"2007","journal-title":"Am. J. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S1474-4422(18)30311-9","article-title":"Comorbidities, Treatment, and Pathophysiology in Restless Legs Syndrome","volume":"17","author":"Trenkwalder","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1212\/WNL.0000000000004814","article-title":"Prospective Study of Restless Legs Syndrome and Total and Cardiovascular Mortality among Women","volume":"90","author":"Li","year":"2018","journal-title":"Neurology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2165\/11317500-000000000-00000","article-title":"Depressive Disorders in Restless Legs Syndrome: Epidemiology, Pathophysiology and Management","volume":"24","author":"Hornyak","year":"2010","journal-title":"CNS Drugs"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.sleep.2004.03.006","article-title":"Impact, Diagnosis and Treatment of Restless Legs Syndrome (RLS) in a Primary Care Population: The REST (RLS Epidemiology, Symptoms, and Treatment) Primary Care Study","volume":"5","author":"Hening","year":"2004","journal-title":"Sleep Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1378\/chest.129.1.76","article-title":"Prevalence and Correlates of Restless Legs Syndrome","volume":"129","author":"Phillips","year":"2006","journal-title":"Chest"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archinte.165.11.1286","article-title":"Restless Legs Syndrome Prevalence and Impact: REST General Population Study","volume":"165","author":"Allen","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/j.1532-5415.2007.01294.x","article-title":"Symptoms of Restless Legs Syndrome in Older Adults: Outcomes on Sleep Quality, Sleepiness, Fatigue, Depression, and Quality of Life: Effects of Symptom Severity of Rls in Older Adults","volume":"55","author":"Cuellar","year":"2007","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1080\/09638288.2018.1453875","article-title":"Non-Pharmacological Interventions for Restless Legs Syndrome: A Systematic Review of Randomised Controlled Trials","volume":"41","author":"Harrison","year":"2019","journal-title":"Disabil. Rehabil."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.smrv.2017.06.002","article-title":"The Influence of Antidepressants on Restless Legs Syndrome and Periodic Limb Movements: A Systematic Review","volume":"38","author":"Kolla","year":"2018","journal-title":"Sleep Med. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s13311-013-0247-9","article-title":"Treatment of Restless Legs Syndrome","volume":"11","author":"Comella","year":"2014","journal-title":"Neurotherapeutics"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.sleep.2008.12.003","article-title":"The Importance of Oral Iron Therapy in Restless Legs Syndrome","volume":"10","author":"Earley","year":"2009","journal-title":"Sleep Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.sleep.2012.11.001","article-title":"Lower Molecular Weight Intravenous Iron Dextran for Restless Legs Syndrome","volume":"14","author":"Cho","year":"2013","journal-title":"Sleep Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.sleep.2008.11.003","article-title":"Efficacy of Oral Iron in Patients with Restless Legs Syndrome and a Low-Normal Ferritin: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"10","author":"Wang","year":"2009","journal-title":"Sleep Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejim.2017.04.018","article-title":"Clinical Management of Iron Deficiency Anemia in Adults: Systemic Review on Advances in Diagnosis and Treatment","volume":"42","author":"Iolascon","year":"2017","journal-title":"Eur. J. Intern. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1517\/14740338.3.5.485","article-title":"Safety of Benzodiazepines in the Geriatric Population","volume":"3","author":"Madhusoodanan","year":"2004","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejpain.2004.07.011","article-title":"Opioid Use in the Elderly","volume":"9","year":"2005","journal-title":"Eur. J. Pain"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2147\/NDT.S49454","article-title":"Efficacy and Tolerability of Pramipexole for the Treatment of Primary Restless Leg Syndrome: A Meta-Analysis of Randomized Placebo-Controlled Trials","volume":"9","author":"Zhang","year":"2013","journal-title":"NDT"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1592\/phco.29.3.255","article-title":"Effect of Ropinirole on Sleep Outcomes in Patients with Restless Legs Syndrome: Meta-Analysis of Pooled Individual Patient Data from Randomized Controlled Trials","volume":"29","author":"Hansen","year":"2009","journal-title":"Pharmacotherapy"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/sleep\/22.8.1073","article-title":"Rapid Onset of Action of Levodopa in Restless Legs Syndrome: A Double-Blind, Randomized, Multicenter, Crossover Trial","volume":"22","author":"Kurella","year":"1999","journal-title":"Sleep"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/sleep\/18.8.681","article-title":"L-Dopa Therapy of Uremic and Idiopathic Restless Legs Syndrome: A Double-Blind, Crossover Trial","volume":"18","author":"Trenkwalder","year":"1995","journal-title":"Sleep"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/sleep\/32.2.159","article-title":"A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of Xp13512\/Gsk1838262 in the Treatment of Patients with Primary Restless Legs Syndrome","volume":"32","author":"Kushida","year":"2009","journal-title":"Sleep"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/WNF.0b013e3181b3ab16","article-title":"Gabapentin Enacarbil in Restless Legs Syndrome: A Phase 2b, 2-Week, Randomized, Double-Blind, Placebo-Controlled Trial","volume":"32","author":"Walters","year":"2009","journal-title":"Clin. Neuropharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1212\/01.wnl.0000341770.91926.cc","article-title":"Randomized, Double-Blind, Placebo-Controlled Study of XP13512\/GSK1838262 in Patients with RLS","volume":"72","author":"Kushida","year":"2009","journal-title":"Neurology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5664\/JCSM.1074","article-title":"A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Tolerability of Gabapentin Enacarbil in Subjects with Restless Legs Syndrome","volume":"07","author":"Lee","year":"2011","journal-title":"J. Clin. Sleep Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.sleep.2010.03.003","article-title":"A Randomized, Double-Blind, 6-Week, Dose-Ranging Study of Pregabalin in Patients with Restless Legs Syndrome","volume":"11","author":"Allen","year":"2010","journal-title":"Sleep Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"121","DOI":"10.5665\/sleep.5332","article-title":"The Clinical Phenotype of Idiopathic Rapid Eye Movement Sleep Behavior Disorder at Presentation: A Study in 203 Consecutive Patients","volume":"39","author":"Iranzo","year":"2016","journal-title":"Sleep"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1474-4422(16)00057-0","article-title":"Idiopathic Rapid Eye Movement Sleep Behaviour Disorder: Diagnosis, Management, and the Need for Neuroprotective Interventions","volume":"15","author":"Iranzo","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Haba-Rubio, J., Frauscher, B., Marques-Vidal, P., Toriel, J., Tobback, N., Andries, D., Preisig, M., Vollenweider, P., Postuma, R., and Heinzer, R. (2018). Prevalence and Determinants of Rapid Eye Movement Sleep Behavior Disorder in the General Population. Sleep, 41.","DOI":"10.1093\/sleep\/zsx197"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/jsr.12486","article-title":"Quality of Life in Patients with an Idiopathic Rapid Eye Movement Sleep Behaviour Disorder in Korea","volume":"26","author":"Kim","year":"2017","journal-title":"J. Sleep Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.sleep.2014.06.002","article-title":"Factors Associated with Injury in REM Sleep Behavior Disorder","volume":"15","author":"McCarter","year":"2014","journal-title":"Sleep Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1212\/WNL.51.2.526","article-title":"Sleep-Related Violence, Injury, and REM Sleep Behavior Disorder in Parkinson\u2019s Disease","volume":"51","author":"Comella","year":"1998","journal-title":"Neurology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.sleep.2012.10.009","article-title":"Delayed Emergence of a Parkinsonian Disorder or Dementia in 81% of Older Men Initially Diagnosed with Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A 16-Year Update on a Previously Reported Series","volume":"14","author":"Schenck","year":"2013","journal-title":"Sleep Med."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Iranzo, A., Fern\u00e1ndez-Arcos, A., Tolosa, E., Serradell, M., Molinuevo, J.L., Valldeoriola, F., Gelpi, E., Vilaseca, I., S\u00e1nchez-Valle, R., and Llad\u00f3, A. (2014). Neurodegenerative Disorder Risk in Idiopathic REM Sleep Behavior Disorder: Study in 174 Patients. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0089741"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/brain\/awz014","article-title":"REM Sleep Behaviour Disorder: An Early Window for Prevention in Neurodegeneration?","volume":"142","author":"Weil","year":"2019","journal-title":"Brain"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3389\/fneur.2018.00961","article-title":"Excessive Daytime Sleepiness and REM Sleep Behavior Disorders in Parkinson\u2019s Disease: A Narrative Review on Early Intervention with Implications to Neuroprotection","volume":"9","author":"Gjerstad","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/mds.25037","article-title":"A Single-Question Screen for Rapid Eye Movement Sleep Behavior Disorder: A Multicenter Validation Study: REM Sleep Behavior Disorder Screen","volume":"27","author":"Postuma","year":"2012","journal-title":"Mov. Disord."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"475","DOI":"10.5664\/jcsm.2670","article-title":"Validation of the Mayo Sleep Questionnaire to Screen for REM Sleep Behavior Disorder in a Community-Based Sample","volume":"9","author":"Boeve","year":"2013","journal-title":"J. Clin. Sleep Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"262","DOI":"10.5694\/mja17.00321","article-title":"REM Sleep Behaviour Disorder: Not Just a Bad Dream","volume":"207","author":"Matar","year":"2017","journal-title":"Med. J. Aust."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Overeem, S., and Reading, P. (2018). Pharmacological Treatment of Insomnia and Parasomnias. Sleep Disorders in Neurology, John Wiley & Sons, Ltd.","DOI":"10.1002\/9781118777251"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.sleep.2015.12.020","article-title":"A Prospective, Naturalistic Follow-up Study of Treatment Outcomes with Clonazepam in Rapid Eye Movement Sleep Behavior Disorder","volume":"21","author":"Li","year":"2016","journal-title":"Sleep Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/acn3.753","article-title":"Prolonged\u2013Release Melatonin in Patients with Idiopathic REM Sleep Behavior Disorder","volume":"6","author":"Jun","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jns.2019.04.029","article-title":"Clonazepam for Probable REM Sleep Behavior Disorder in Parkinson\u2019s Disease: A Randomized Placebo-Controlled Trial","volume":"401","author":"Shin","year":"2019","journal-title":"J. Neurol. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/mds.27886","article-title":"Melatonin for Rapid Eye Movement Sleep Behavior Disorder in Parkinson\u2019s Disease: A Randomised Controlled Trial","volume":"35","author":"Gilat","year":"2020","journal-title":"Mov. Disord."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"85","DOI":"10.5664\/jcsm.27717","article-title":"Best Practice Guide for the Treatment of REM Sleep Behavior Disorder (RBD)","volume":"6","author":"Aurora","year":"2010","journal-title":"J. Clin. Sleep Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"P251","DOI":"10.1093\/geronj\/49.6.P251","article-title":"Age Differences in the Symptoms of Depression: A Latent Trait Analysis","volume":"49","author":"Gallo","year":"1994","journal-title":"J. Gerontol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.clinpsy.032408.153621","article-title":"Depression in Older Adults","volume":"5","author":"Fiske","year":"2009","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"P45","DOI":"10.1093\/geronj\/43.2.P45","article-title":"A Longitudinal Study of Depressed Mood and Sleep Disturbances in Elderly Adults","volume":"43","author":"Rodin","year":"1988","journal-title":"J. Gerontol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1111\/jcmm.14170","article-title":"Depression in Sleep Disturbance: A Review on a Bidirectional Relationship, Mechanisms and Treatment","volume":"23","author":"Fang","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/sleep\/31.4.489","article-title":"Cognitive Behavioral Therapy for Insomnia Enhances Depression Outcome in Patients with Comorbid Major Depressive Disorder and Insomnia","volume":"31","author":"Manber","year":"2008","journal-title":"Sleep"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Sadler, P., McLaren, S., Klein, B., Harvey, J., and Jenkins, M. (2018). Cognitive Behavior Therapy for Older Adults with Insomnia and Depression: A Randomized Controlled Trial in Community Mental Health Services. Sleep, 41.","DOI":"10.1093\/sleep\/zsy104"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.psc.2016.04.009","article-title":"Adverse Effects of Psychotropic Medications on Sleep","volume":"39","author":"Doghramji","year":"2016","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12991-016-0115-1","article-title":"Effect of Mirtazapine versus Selective Serotonin Reuptake Inhibitors on Benzodiazepine Use in Patients with Major Depressive Disorder: A Pragmatic, Multicenter, Open-Label, Randomized, Active-Controlled, 24-Week Trial","volume":"15","author":"Hashimoto","year":"2016","journal-title":"Ann. Gen. Psychiatry"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0006-3223(00)00882-9","article-title":"Acute Effects of Mirtazapine on Sleep Continuity and Sleep Architecture in Depressed Patients: A Pilot Study","volume":"48","author":"Winokur","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Mouret, J., Lemoine, P., Minuit, M.P., Benkelfat, C., and Renardet, M. (1988). Effects of Trazodone on the Sleep of Depressed Subjects? A Polygraphic Study. Psychopharmacology, 95.","DOI":"10.1007\/BF00172629"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Salva, M.-A.Q., Vanier, B., Laredo, J., Hartley, S., Chapotot, F., Moulin, C., Lofaso, F., and Guilleminault, C. (2007). Major Depressive Disorder, Sleep EEG and Agomelatine: An Open-Label Study. Int. J. Neuropsychopharm., 10.","DOI":"10.1017\/S1461145707007754"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/14656566.2019.1574747","article-title":"Agomelatine for Depression: Expanding the Horizons?","volume":"20","author":"Norman","year":"2019","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00005082-200407000-00003","article-title":"Sleep Difficulties, Daytime Sleepiness, and Health-Related Quality of Life in Patients with Chronic Heart Failure","volume":"19","author":"Fridlund","year":"2004","journal-title":"J. Cardiovasc. Nurs."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"On Behalf of the Italian Society of Cardiology (SIC) Working Group on Heart Failure Members, Parati, G., Lombardi, C., Castagna, F., Mattaliano, P., Filardi, P.P., and Agostoni, P. (2016). Heart Failure and Sleep Disorders. Nat. Rev. Cardiol., 13, 389\u2013403.","DOI":"10.1038\/nrcardio.2016.71"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1161\/CIRCULATIONAHA.111.070813","article-title":"Sleep Apnea and Cardiovascular Disease: A Bidirectional Relationship","volume":"126","author":"Kasai","year":"2012","journal-title":"Circulation"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1093\/sleep\/33.9.1210","article-title":"Insomnia Symptoms and Daytime Function in Stable Heart Failure","volume":"33","author":"Redeker","year":"2010","journal-title":"Sleep"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10741-008-9102-1","article-title":"Insomnia and Chronic Heart Failure","volume":"14","author":"Hayes","year":"2009","journal-title":"Heart Fail. Rev."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2174\/157340310790231635","article-title":"Sleep Duration as a Risk Factor for Cardiovascular Disease-a Review of the Recent Literature","volume":"6","author":"Nagai","year":"2010","journal-title":"CCR"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"315","DOI":"10.5551\/jat.RV17032","article-title":"Sleep Disordered Breathing and Cardiovascular Diseases","volume":"26","author":"Yoshihisa","year":"2019","journal-title":"JAT"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s11897-017-0322-3","article-title":"Orexin: A Missing Link between Sleep Disorders and Heart Failure?","volume":"14","author":"Pan","year":"2017","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/JCN.0b013e31829b675e","article-title":"Heart Failure Symptom Relationships: A Systematic Review","volume":"29","author":"Herr","year":"2014","journal-title":"J. Cardiovasc. Nurs."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5664\/jcsm.4454","article-title":"Associations of Heart Failure with Sleep Quality: The Rotterdam Study","volume":"11","author":"Zuurbier","year":"2015","journal-title":"J. Clin. Sleep Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cardfail.2012.05.002","article-title":"Nocturia, Sleep and Daytime Function in Stable Heart Failure","volume":"18","author":"Redeker","year":"2012","journal-title":"J. Card. Fail."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e13027","DOI":"10.1111\/ijcp.13027","article-title":"A Practical Approach to the Management of Nocturia","volume":"71","author":"Oelke","year":"2017","journal-title":"Int. J. Clin. Pract."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/BF00878091","article-title":"Effects of 12 Weeks of Ramipril Treatment on the Quality of Life in Patients with Moderate Congestive Heart Failure: Results of a Placebo-Controlled Trial","volume":"9","author":"Gundersen","year":"1995","journal-title":"Cardiovasc. Drug Ther."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1136\/hrt.73.3.237","article-title":"Effects of Captopril and Oxygen on Sleep Apnoea in Patients with Mild to Moderate Congestive Cardiac Failure","volume":"73","author":"Walsh","year":"1995","journal-title":"Heart"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1378\/chest.06-0919","article-title":"Relationship between \u03b2-Blocker Treatment and the Severity of Central Sleep Apnea in Chronic Heart Failure","volume":"131","author":"Tamura","year":"2007","journal-title":"Chest"},{"key":"ref_163","first-page":"388","article-title":"Nocturia","volume":"37","author":"Lane","year":"2019","journal-title":"Surgery"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1440-1843.2012.02217.x","article-title":"Sleep Quality in Chronic Obstructive Pulmonary Disease: Sleep Quality in COPD","volume":"17","author":"Mcsharry","year":"2012","journal-title":"Respirology"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.sleep.2010.08.017","article-title":"Sleep Profile and Symptoms of Sleep Disorders in Patients with Stable Mild to Moderate Chronic Obstructive Pulmonary Disease","volume":"12","author":"Valipour","year":"2011","journal-title":"Sleep Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"610","DOI":"10.21215\/kjfp.2016.6.6.610","article-title":"Risk Factors Associated with the Quality of Sleep of Patients with Chronic Obstructive Pulmonary Disease","volume":"6","author":"Jung","year":"2016","journal-title":"Korean J. Fam. Pract."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.anai.2020.04.035","article-title":"Associations of Sleep Duration with Patient-Reported Outcomes and Health Care Use in US Adults with Asthma","volume":"125","author":"Luyster","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_168","first-page":"27","article-title":"Sleep Disturbances and Asthma Control: A Real Life Study","volume":"27","author":"Braido","year":"2009","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/02770900801890224","article-title":"Sleep Quality in Asthma: Results of a Large Prospective Clinical Trial","volume":"45","author":"Mastronarde","year":"2008","journal-title":"J. Asthma"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-079X.2008.00621.x","article-title":"Melatonin Attenuates Lipopolysaccharide-Induced Acute Lung Inflammation in Sleep-Deprived Mice","volume":"46","author":"Lee","year":"2009","journal-title":"J. Pineal Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1378\/chest.91.1.29","article-title":"The Effect of Sleep Loss on Breathing in Chronic Obstructive Pulmonary Disease","volume":"91","author":"Phillips","year":"1987","journal-title":"Chest"},{"key":"ref_172","first-page":"194","article-title":"Effect of Sleep on Breathing\u2014Why Recurrent Apneas Are Only Seen during Sleep","volume":"4","author":"Xie","year":"2012","journal-title":"J. Thorac. Dis."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"190064","DOI":"10.1183\/16000617.0064-2019","article-title":"Sleep in Chronic Respiratory Disease: COPD and Hypoventilation Disorders","volume":"28","author":"McNicholas","year":"2019","journal-title":"Eur. Respir. Rev."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"259","DOI":"10.5664\/jcsm.4540","article-title":"Sleep Disorders in Chronic Obstructive Pulmonary Disease: Etiology, Impact, and Management","volume":"11","author":"Budhiraja","year":"2015","journal-title":"J. Clin. Sleep Med."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"The Long-Term Oxygen Treatment Trial Research Group (2016). A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation. N. Engl. J. Med., 375, 1617\u20131627.","DOI":"10.1056\/NEJMoa1604344"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1600-0773.1996.tb00249.x","article-title":"Effects of Dexamethasone on Sleep","volume":"79","author":"Moser","year":"1996","journal-title":"Pharmacol. Toxicol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1378\/chest.108.2.382","article-title":"Effects of Theophylline on Nocturnal Sleep and Daytime Sleepiness\/Alertness","volume":"108","author":"Roehrs","year":"1995","journal-title":"Chest"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s13665-012-0013-1","article-title":"Respiratory Medications and Sleep","volume":"1","author":"Bercovitch","year":"2012","journal-title":"Curr. Respir. Care Rep."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.sleep.2008.06.005","article-title":"Hypnotic Use for Insomnia Management in Chronic Obstructive Pulmonary Disease","volume":"10","author":"Roth","year":"2009","journal-title":"Sleep Med."},{"key":"ref_180","first-page":"P3477","article-title":"Effect of Melatonin on Sleep Quality of Chronic Obstructive Pulmonary Disease (COPD) Patients","volume":"40","author":"Halvani","year":"2012","journal-title":"Eur. Respir. J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1590\/S0100-879X2008001000016","article-title":"Effect of Melatonin Administration on Subjective Sleep Quality in Chronic Obstructive Pulmonary Disease","volume":"41","author":"Nunes","year":"2008","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1600-079X.2012.00992.x","article-title":"Melatonin Reduces Lung Oxidative Stress in Patients with Chronic Obstructive Pulmonary Disease: A Randomized, Double-Blind, Placebo-Controlled Study: Melatonin Reduces Oxidative Stress in COPD","volume":"53","author":"Nunes","year":"2012","journal-title":"J. Pineal Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0304-3959(99)00213-4","article-title":"Sleep Arousal Response to Experimental Thermal Stimulation during Sleep in Human Subjects Free of Pain and Sleep Problems","volume":"84","author":"Lavigne","year":"2000","journal-title":"Pain"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/sleep\/30.4.494","article-title":"The Effects of Sleep Deprivation on Pain Inhibition and Spontaneous Pain in Women","volume":"30","author":"Smith","year":"2007","journal-title":"Sleep"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1002\/art.38329","article-title":"Poor Sleep Quality Is Strongly Associated With Subsequent Pain Intensity in Patients with Acute Low Back Pain: Sleep Quality and Pain Intensity","volume":"66","author":"Alsaadi","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0304-3959(96)03226-5","article-title":"Sequential Daily Relations of Sleep, Pain Intensity, and Attention to Pain among Women with Fibromyalgia","volume":"68","author":"Affleck","year":"1996","journal-title":"Pain"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2217\/pmt-2020-0001","article-title":"Sleep and Pain Management: A Review","volume":"10","author":"Woo","year":"2020","journal-title":"Pain Manag."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/ebnurs-2018-102934","article-title":"Evidence That Active Pain Treatment Improves Sleep Quality and Quantity in People with Depression and Dementia","volume":"22","author":"Swift","year":"2019","journal-title":"Evid. Based Nurs."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/j.pain.0000000000001423","article-title":"Improving Pain and Sleep in Middle-Aged and Older Adults: The Promise of Behavioral Sleep Interventions","volume":"160","author":"Koffel","year":"2019","journal-title":"Pain"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cgh.2009.03.007","article-title":"A Population-Based Study Showing an Association between Gastroesophageal Reflux Disease and Sleep Problems","volume":"7","author":"Jansson","year":"2009","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1572-0241.2003.07531.x","article-title":"Nighttime Heartburn Is an Under-Appreciated Clinical Problem That Impacts Sleep and Daytime Function: The Results of a Gallup Survey Conducted on Behalf of the American Gastroenterological Association","volume":"98","author":"Shaker","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5056\/jnm.2010.16.1.22","article-title":"Gastroesophageal Reflux Disease and Sleep Disorders: Evidence for a Causal Link and Therapeutic Implications","volume":"16","author":"Jung","year":"2010","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s00535-012-0601-4","article-title":"Gastroesophageal Reflux Disease and Sleep Disturbances","volume":"47","author":"Fujiwara","year":"2012","journal-title":"J. Gastroenterol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1111\/j.1572-0241.2005.00285.x","article-title":"Effect of Esomeprazole on Nighttime Heartburn and Sleep Quality in Patients with GERD: A Randomized, Placebo-Controlled Trial","volume":"100","author":"Johnson","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.smrv.2010.03.002","article-title":"The Effect of Nocturia on Sleep","volume":"15","author":"Bliwise","year":"2011","journal-title":"Sleep Med. Rev."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1464-410X.2006.06380.x","article-title":"Impact of Surgical Treatment on Nocturia in Men with Benign Prostatic Obstruction","volume":"98","author":"Cai","year":"2006","journal-title":"BJU Int."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.urology.2005.10.054","article-title":"Impact of Nocturia on Symptom-Specific Quality of Life among Community-Dwelling Adults Aged 40 Years and Older","volume":"67","author":"Yu","year":"2006","journal-title":"Urology"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/nau.22724","article-title":"Nocturia Is Associated with Loss of Deep Sleep Independently from Sleep Apnea: Sleep Apnea Is a Well-Acknowledged Reversible","volume":"34","author":"Bliwise","year":"2015","journal-title":"Neurourol. Urodynam."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.5664\/jcsm.5.2S.S4","article-title":"Slow Wave Sleep: Does It Matter?","volume":"5","author":"Roth","year":"2009","journal-title":"J. Clin. Sleep Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.sleep.2008.04.002","article-title":"Nocturia and Disturbed Sleep in the Elderly","volume":"10","author":"Bliwise","year":"2009","journal-title":"Sleep Med."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5213\/inj.1938026.013","article-title":"Effect of Nocturnal Hypoxia on Nocturia in Patients with Obstructive Sleep Apnea","volume":"23","author":"Chung","year":"2019","journal-title":"Int. Neurourol. J."},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Kabadi, U.M. (2016). SGLT2 Inhibitors: Far Too Many Cautions and Alerts and Limited Efficacy. JDMDC, 3.","DOI":"10.15406\/jdmdc.2016.03.00077"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/j.1464-410X.2011.10593.x","article-title":"Commonly Used Antihypertensives and Lower Urinary Tract Symptoms: Results from the Boston Area Community Health (BACH) Survey: Antihypertensives and Luts","volume":"109","author":"Hall","year":"2012","journal-title":"BJU Int."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jsmc.2017.09.010","article-title":"Sleep and Nocturia in Older Adults","volume":"13","author":"Vaughan","year":"2018","journal-title":"Sleep Med. Clin."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/nau.23939","article-title":"International Continence Society Consensus on the Diagnosis and Treatment of Nocturia","volume":"38","author":"Everaert","year":"2019","journal-title":"Neurourol. Urodyn."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5664\/jcsm.4364","article-title":"Short Time to First Void Is Associated with Lower Whole-Night Sleep Quality in Nocturia Patients","volume":"11","author":"Bliwise","year":"2015","journal-title":"J. Clin. Sleep Med."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.sleh.2015.05.001","article-title":"Delay of First Voiding Episode Is Associated with Longer Reported Sleep Duration","volume":"1","author":"Bliwise","year":"2015","journal-title":"Sleep Health"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.aah4968","article-title":"Mechanisms Linking Circadian Clocks, Sleep, and Neurodegeneration","volume":"354","author":"Musiek","year":"2016","journal-title":"Science"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2147\/NSS.S78947","article-title":"Chronic Sleep Disturbance and Neural Injury: Links to Neurodegenerative Disease","volume":"8","author":"Videnovic","year":"2016","journal-title":"NSS"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11910-013-0373-0","article-title":"Parkinson Disease and Sleep: Sleep\u2013Wake Changes in the Premotor Stage of Parkinson Disease; Impaired Olfaction and Other Prodromal Features","volume":"13","author":"Iranzo","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1093\/brain\/aws093","article-title":"How Does Parkinsonism Start? Prodromal Parkinsonism Motor Changes in Idiopathic REM Sleep Behaviour Disorder","volume":"135","author":"Postuma","year":"2012","journal-title":"Brain"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jns.2011.07.049","article-title":"Sleep\u2013Wake Changes in the Premotor Stage of Parkinson Disease","volume":"310","author":"Iranzo","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.parkreldis.2017.12.022","article-title":"Poor Nighttime Sleep Is Positively Associated with Dyskinesia in Parkinson\u2019s Disease Patients","volume":"48","author":"Mao","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.parkreldis.2013.03.014","article-title":"\u201cSleep Benefit\u201d in Parkinson\u2019s Disease: A Systematic Review","volume":"19","author":"Bloem","year":"2013","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/nau.20193","article-title":"Prevalence of Bladder Dysfunction in Parkinsons Disease","volume":"25","author":"Winge","year":"2006","journal-title":"Neurourol. Urodyn."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/nau.22365","article-title":"Nocturia and Overnight Polysomnography in Parkinson Disease: Nocturia and Polysomnography in Parkinson Disease","volume":"32","author":"Vaughan","year":"2013","journal-title":"Neurourol. Urodynam."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1001\/archneur.1994.00540210094018","article-title":"Sleep Disruption in Parkinson\u2019s Disease: Assessment by Continuous Activity Monitoring","volume":"51","year":"1994","journal-title":"Arch. Neurol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000116692","article-title":"Sleep Disorders, Pain, and Depression in Parkinson\u2019s Disease","volume":"31","author":"Starkstein","year":"1991","journal-title":"Eur. Neurol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/ncpneuro0775","article-title":"Sleep Disturbances in Patients with Parkinsonism","volume":"4","author":"Vidailhet","year":"2008","journal-title":"Nat. Rev. Neurol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/mds.26431","article-title":"MDS Research Criteria for Prodromal Parkinson\u2019s Disease: MDS Criteria for Prodromal PD","volume":"30","author":"Berg","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1053\/smrv.2002.0229","article-title":"Parkinson\u2019s Disease and Sleep","volume":"7","author":"Larrosa","year":"2003","journal-title":"Sleep Med. Rev."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1468-1331.2010.03213.x","article-title":"Effect of Controlled-Release Levodopa on the Microstructure of Sleep in Parkinson\u2019s Disease: L-Dopa Effect on PD Sleep","volume":"18","author":"Wailke","year":"2011","journal-title":"Eur. J. Neurol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/mds.10242","article-title":"Microstructure of the Non-Rapid Eye Movement Sleep Electroencephalogram in Patients with Newly Diagnosed Parkinson\u2019s Disease: Effects of Dopaminergic Treatment","volume":"17","author":"Brunner","year":"2002","journal-title":"Mov. Disord."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1007\/PL00007731","article-title":"Sleep Disorders in Parkinson\u2019s Disease","volume":"245","author":"Stocchi","year":"1998","journal-title":"J. Neurol."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Loddo, G., Calandra-Buonaura, G., Sambati, L., Giannini, G., Cecere, A., Cortelli, P., and Provini, F. (2017). The Treatment of Sleep Disorders in Parkinson\u2019s Disease: From Research to Clinical Practice. Front. Neurol., 8.","DOI":"10.3389\/fneur.2017.00042"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.sleep.2016.01.016","article-title":"Rotigotine May Improve Sleep Architecture in Parkinson\u2019s Disease: A Double-Blind, Randomized, Placebo-Controlled Polysomnographic Study","volume":"21","author":"Pierantozzi","year":"2016","journal-title":"Sleep Med."},{"key":"ref_227","first-page":"1","article-title":"Rotigotine Objectively Improves Sleep in Parkinson\u2019s Disease: An Open-Label Pilot Study with Actigraphic Recording","volume":"2016","author":"Guaraldi","year":"2016","journal-title":"Parkinson\u2019s Dis."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.2147\/NDT.S116476","article-title":"Rasagiline for Sleep Disorders in Patients with Parkinson&rsquo\u2019s Disease: A Prospective Observational Study","volume":"12","author":"Melone","year":"2016","journal-title":"NDT"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.clinthera.2016.09.010","article-title":"Review of Safety and Efficacy of Sleep Medicines in Older Adults","volume":"38","author":"Schroeck","year":"2016","journal-title":"Clin. Ther."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00002826-200303000-00005","article-title":"Study of Circadian Melatonin Secretion Pattern at Different Stages of Parkinson\u2019s Disease","volume":"26","author":"Bordet","year":"2003","journal-title":"Clin. Neuropharmacol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.sleep.2005.04.004","article-title":"Melatonin for Sleep Disturbances in Parkinson\u2019s Disease","volume":"6","author":"Dowling","year":"2005","journal-title":"Sleep Med."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00415-006-0390-x","article-title":"Effect of Exogenous Melatonin on Sleep and Motor Dysfunction in Parkinson\u2019s Disease: A Randomized, Double Blind, Placebo-Controlled Study","volume":"254","author":"Medeiros","year":"2007","journal-title":"J. Neurol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"105031","DOI":"10.1016\/j.nbd.2020.105031","article-title":"It\u2019s Complicated: The Relationship between Sleep and Alzheimer\u2019s Disease in Humans","volume":"144","author":"Lucey","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000434629","article-title":"Sleep and Cognitive Decline: A Strong Bidirectional Relationship. It Is Time for Specific Recommendations on Routine Assessment and the Management of Sleep Disorders in Patients with Mild Cognitive Impairment and Dementia","volume":"74","author":"Guarnieri","year":"2015","journal-title":"Eur. Neurol."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Lloret, M.-A., Cervera-Ferri, A., Nepomuceno, M., Monllor, P., Esteve, D., and Lloret, A. (2020). Is Sleep Disruption a Cause or Consequence of Alzheimer\u2019s Disease? Reviewing Its Possible Role as a Biomarker. IJMS, 21.","DOI":"10.3390\/ijms21031168"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Bubu, O.M., Brannick, M., Mortimer, J., Umasabor-Bubu, O., Sebasti\u00e3o, Y.V., Wen, Y., Schwartz, S., Borenstein, A.R., Wu, Y., and Morgan, D. (2017). Sleep, Cognitive Impairment, and Alzheimer\u2019s Disease: A Systematic Review and Meta-Analysis. Sleep, 40.","DOI":"10.1093\/sleep\/zsw032"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11940-003-0017-9","article-title":"Sleep Dysfunction in Alzheimer\u2019s Disease and Other Dementias","volume":"5","author":"McCurry","year":"2003","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3389\/fnins.2018.00330","article-title":"Sleep Disorders Associated With Alzheimer\u2019s Disease: A Perspective","volume":"12","author":"Brzecka","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000439252","article-title":"Higher Frequency and Complexity of Sleep Disturbances in Dementia with Lewy Bodies as Compared to Alzheimer\u2019s Disease","volume":"16","author":"Chwiszczuk","year":"2016","journal-title":"Neurodegener. Dis."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF01321316","article-title":"Sleep Problems in the Community Elderly as Predictors of Death and Nursing Home Placement","volume":"15","author":"Pollak","year":"1990","journal-title":"J. Community Health"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/089198879901200203","article-title":"Characteristics of Sleep Disturbance in Community-Dwelling Alzheimer\u2019s Disease Patients","volume":"12","author":"McCurry","year":"1999","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.gerinurse.2017.06.003","article-title":"Impact of Alzheimer Disease Patients\u2019 Sleep Disturbances on Their Caregivers","volume":"39","author":"Gehrman","year":"2018","journal-title":"Geriatr. Nurs."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1007\/s00415-019-09286-0","article-title":"Association between Sleep Disturbance in Alzheimer\u2019s Disease Patients and Burden on and Health Status of Their Caregivers","volume":"266","author":"Okuda","year":"2019","journal-title":"J. Neurol."},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"McCleery, J., Cohen, D.A., and Sharpley, A.L. (2014). Pharmacotherapies for Sleep Disturbances in Alzheimer\u2019s Disease. Cochrane Database of Systematic Reviews, The Cochrane Collaboration; John Wiley & Sons, Ltd.","DOI":"10.1002\/14651858.CD009178.pub2"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/1533317514568005","article-title":"Melatonin for Sleep Disorders and Cognition in Dementia: A Meta-Analysis of Randomized Controlled Trials","volume":"30","author":"Xu","year":"2015","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/gps.2454","article-title":"Effectiveness of Melatonin Treatment on Circadian Rhythm Disturbances in Dementia. Are There Implications for Delirium? A Systematic Review","volume":"25","author":"Korevaar","year":"2010","journal-title":"Int. J. Geriat. Psychiatry"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11920-019-1049-5","article-title":"Management of Behavioral and Psychological Symptoms of Dementia","volume":"21","author":"Bessey","year":"2019","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.maturitas.2019.06.007","article-title":"Non-Pharmacological Treatments for Sleep Disturbance in Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis","volume":"127","author":"Mannion","year":"2019","journal-title":"Maturitas"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/07317115.2017.1384777","article-title":"Neuropsychological Functioning in Older Adults with Mild Cognitive Impairment and Insomnia Randomized to CBT-I or Control Group","volume":"41","author":"Siebern","year":"2018","journal-title":"Clin. Gerontol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"zsaa034","DOI":"10.1093\/sleep\/zsaa034","article-title":"The Effects of Digital Cognitive Behavioral Therapy for Insomnia on Cognitive Function: A Randomized Controlled Trial","volume":"43","author":"Kyle","year":"2020","journal-title":"Sleep"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.pop.2005.02.009","article-title":"Medications and Their Effects on Sleep","volume":"32","author":"Pagel","year":"2005","journal-title":"Prim. Care Clin. Off. Pract."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2125.2011.04010.x","article-title":"Potentially Inappropriate Medications in Geriatric Outpatients with Polypharmacy: Application of Six Sets of Published Explicit Criteria: Potentially Inappropriate Medications in Geriatric Outpatients","volume":"72","author":"Chang","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.sjbs.2016.05.006","article-title":"Potentially Inappropriate Medications Prescribed for Elderly Patients through Family Physicians","volume":"24","author":"Tourkmani","year":"2017","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"bjgpopen20X101009","DOI":"10.3399\/bjgpopen20X101009","article-title":"Potentially Inappropriate Medications in Older Patients Based on Beers Criteria: A Cross-Sectional Study of a Family Medicine Practice in Saudi Arabia","volume":"4","author":"Alturki","year":"2020","journal-title":"BJGP Open"},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Kumar, S., Wong, P.S., Hasan, S.S., and Kairuz, T. (2019). The Relationship between Sleep Quality, Inappropriate Medication Use and Frailty among Older Adults in Aged Care Homes in Malaysia. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0224122"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/2042098617736192","article-title":"Poly-de-Prescribing to Treat Polypharmacy: Efficacy and Safety","volume":"9","author":"Garfinkel","year":"2018","journal-title":"Ther. Adv. Drug Saf."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1177\/0269215511400639","article-title":"Risk Factors for Geriatric Patient Falls in Rehabilitation Hospital Settings: A Systematic Review","volume":"25","author":"Vieira","year":"2011","journal-title":"Clin. Rehabil."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.36290\/vnl.2018.154","article-title":"Falls: A Significant Cause of Morbidity and Mortality in Elderly People","volume":"64","author":"Berka","year":"2018","journal-title":"Vnitr. Lek."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/S1389-9457(08)70012-1","article-title":"Sleep, Insomnia and Falls in Elderly Patients","volume":"9","author":"Stone","year":"2008","journal-title":"Sleep Med."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.1532-5415.2007.01223.x","article-title":"Sleep Apnea and Falls in Older People: Letters to the Editor","volume":"55","author":"Kaushik","year":"2007","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/gerona\/glp143","article-title":"Gender-Specific Association between Self-Reported Sleep Duration and Falls in High-Functioning Older Adults","volume":"65A","author":"Kuo","year":"2010","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/jgs.12649","article-title":"Sleep Disturbances and Risk of Falls in Older Community-Dwelling Men: The Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study","volume":"62","author":"Stone","year":"2014","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S8756-3282(97)00179-8","article-title":"Case-Control Study of Risk Factors for Hip Fractures in the Japanese Elderly by a Mediterranean Osteoporosis Study (MEDOS) Questionnaire","volume":"21","author":"Suzuki","year":"1997","journal-title":"Bone"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3349\/ymj.2017.58.6.1222","article-title":"Association between Sleep Duration and Injury from Falling among Older Adults: A Cross-Sectional Analysis of Korean Community Health Survey Data","volume":"58","author":"Noh","year":"2017","journal-title":"Yonsei Med. J."},{"key":"ref_265","doi-asserted-by":"crossref","unstructured":"Barker, A., Cameron, P., Flicker, L., Arendts, G., Brand, C., Etherton-Beer, C., Forbes, A., Haines, T., Hill, A.-M., and Hunter, P. (2019). Evaluation of Respond, a Patient-Centred Program to Prevent Falls in Older People Presenting to the Emergency Department with a Fall: A Randomised Controlled Trial. PLoS Med., 16.","DOI":"10.1371\/journal.pmed.1002807"},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Aeschbach, D., and Santhi, N. (2013). Attention and Memory Changes. Encyclopedia of Sleep, Elsevier.","DOI":"10.1016\/B978-0-12-378610-4.00043-7"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/gerona\/62.1.62","article-title":"Sleep Disturbances and Falls in Older People","volume":"62","author":"Hill","year":"2007","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Liu, Y., Chan, J.S.Y., and Yan, J.H. (2014). Neuropsychological Mechanisms of Falls in Older Adults. Front. Aging Neurosci., 6.","DOI":"10.3389\/fnagi.2014.00064"},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Kim, S.Y., Bang, W., Kim, M.-S., Park, B., Kim, J.-H., and Choi, H.G. (2017). Nocturia Is Associated with Slipping and Falling. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169690"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1161\/STROKEAHA.118.023553","article-title":"Sleep and Stroke","volume":"50","author":"Khot","year":"2019","journal-title":"Stroke"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s11940-007-0019-0","article-title":"Sleep Dysfunction in Patients with Cancer","volume":"9","author":"Fiorentino","year":"2007","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/ajh\/hpu071","article-title":"A Review of Evidence for the Link between Sleep Duration and Hypertension","volume":"27","author":"Gangwisch","year":"2014","journal-title":"Am. J. Hypertens."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11892-018-1055-8","article-title":"The Epidemiology of Sleep and Diabetes","volume":"18","author":"Ogilvie","year":"2018","journal-title":"Curr. Diab. Rep."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s11325-019-01824-4","article-title":"Dose-Response Association between Sleep Duration and Obesity Risk: A Systematic Review and Meta-Analysis of Prospective Cohort Studies","volume":"23","author":"Zhou","year":"2019","journal-title":"Sleep Breath"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/MCP.0b013e3283130f96","article-title":"Sleep Disorders and End-Stage Renal Disease","volume":"14","author":"Hanly","year":"2008","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: A New Instrument for Psychiatric Practice and Research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.sleep.2011.04.005","article-title":"Validation of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in Older Black and White Women","volume":"13","author":"Beaudreau","year":"2012","journal-title":"Sleep Med."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/gerona\/glr172","article-title":"Reliability and Validity of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in Older Men","volume":"67A","author":"Spira","year":"2012","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00391-019-01670-9","article-title":"Assessment of Sleep and Sleep Disorders in Geriatric Patients","volume":"53","author":"Frohnhofen","year":"2020","journal-title":"Z Gerontol. Geriat."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"ref_281","first-page":"45","article-title":"Feasibility of the Epworth Sleepiness Scale in a Sample of Geriatric In-Hospital Patients","volume":"60","author":"Frohnhofen","year":"2009","journal-title":"J. Physiol. Pharm."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1389-9457(00)00065-4","article-title":"Validation of the Insomnia Severity Index as an Outcome Measure for Insomnia Research","volume":"2","author":"Bastien","year":"2001","journal-title":"Sleep Med."},{"key":"ref_283","first-page":"566","article-title":"Insomnia Severity Index: Some indicators about its reliability and validity on an older adults sample","volume":"47","author":"Sierra","year":"2008","journal-title":"Rev. Neurol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1111\/j.1365-2648.2010.05394.x","article-title":"Insomnia Severity Index: Psychometric Properties with Chinese Community-Dwelling Older People: Insomnia Severity Index","volume":"66","author":"Yu","year":"2010","journal-title":"J. Adv. Nurs."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.sleh.2018.09.003","article-title":"Assessing Psychometric Properties of the Promis Sleep Disturbance Scale in Older Adults in Independent-Living and Continuing Care Retirement Communities","volume":"5","author":"Full","year":"2019","journal-title":"Sleep Health"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/sleep\/33.6.781","article-title":"Development and Validation of Patient-Reported Outcome Measures for Sleep Disturbance and Sleep-Related Impairments","volume":"33","author":"Buysse","year":"2010","journal-title":"Sleep"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-94-007-4546-9_17","article-title":"Validation of the Essener Questionnaire of Age and Sleepiness in the Elderly Using Pupillometry","volume":"Volume 755","author":"Pokorski","year":"2013","journal-title":"Respiratory Regulation\u2014Clinical Advances"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"485","DOI":"10.7326\/0003-4819-131-7-199910050-00002","article-title":"Using the Berlin Questionnaire To Identify Patients at Risk for the Sleep Apnea Syndrome","volume":"131","author":"Netzer","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.sleep.2010.09.004","article-title":"Is the Berlin Questionnaire a Useful Tool to Diagnose Obstructive Sleep Apnea in the Elderly?","volume":"12","author":"Sforza","year":"2011","journal-title":"Sleep Med."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2466\/pms.107.3.691-706","article-title":"A New Scale for Measuring Insomnia: The Bergen Insomnia Scale","volume":"107","author":"Pallesen","year":"2008","journal-title":"Percept. Mot. Ski."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"199","DOI":"10.5664\/jcsm.8166","article-title":"Exploring the Stop-Bang Questionnaire for Obstructive Sleep Apnea Screening in Seniors","volume":"16","author":"Martins","year":"2020","journal-title":"J. Clin. Sleep Med."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1164\/ajrccm.150.5.7952553","article-title":"Likelihood Ratios for a Sleep Apnea Clinical Prediction Rule","volume":"150","author":"Flemons","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_293","first-page":"275","article-title":"Sleep Apnea Clinical Score, Berlin Questionnaire, or Epworth Sleepiness Scale: Which Is the Best Obstructive Sleep Apnea Predictor in Patients with COPD?","volume":"8","author":"Rufino","year":"2015","journal-title":"IJGM"}],"container-title":["Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3271\/9\/2\/31\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:05:12Z","timestamp":1760162712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3271\/9\/2\/31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,21]]},"references-count":293,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["medsci9020031"],"URL":"https:\/\/doi.org\/10.3390\/medsci9020031","relation":{},"ISSN":["2076-3271"],"issn-type":[{"value":"2076-3271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,21]]}}}