{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:31:30Z","timestamp":1767994290711,"version":"3.49.0"},"reference-count":236,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2014\/15\/B\/ST5\/02185"],"award-info":[{"award-number":["2014\/15\/B\/ST5\/02185"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Membranes"],"abstract":"<jats:p>In the mitochondrial matrix, there are insoluble, osmotically inactive complexes that maintain a constant pH and calcium concentration. In the present paper, we examine the properties of insoluble calcium and magnesium salts, such as phosphates, carbonates and polyphosphates, which might play this role. We find that non-stoichiometric, magnesium-rich carbonated apatite, with very low crystallinity, precipitates in the matrix under physiological conditions. Precipitated salt acts as pH buffer, and, hence, can contribute in maintaining ATP production in ischemic conditions, which delays irreversible damage to heart and brain cells after stroke.<\/jats:p>","DOI":"10.3390\/membranes10050081","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T05:05:32Z","timestamp":1588050332000},"page":"81","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Precipitation of Inorganic Salts in Mitochondrial Matrix"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0465-1823","authenticated-orcid":false,"given":"Jerzy J.","family":"Jasielec","sequence":"first","affiliation":[{"name":"Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4078-1118","authenticated-orcid":false,"given":"Robert","family":"Filipek","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3673-0542","authenticated-orcid":false,"given":"Krzysztof","family":"Do\u0142owy","sequence":"additional","affiliation":[{"name":"Department of Physics and Biophysics, Warsaw University of Life Sciences\u2014SGGW, Nowoursynowska 159, 02-776 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-7296","authenticated-orcid":false,"given":"Andrzej","family":"Lewenstam","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Krakow, Poland"},{"name":"Johan Gadolin Process Chemistry Centre, Centre of Process Analytical Chemistry and Sensor Technology (ProSens), \u00c5bo Akademi University, Biskopsgatan 8, 20500 \u00c5bo-Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1085\/jgp.201110767","article-title":"The renaissance of mitochondrial pH","volume":"139","author":"Demaurex","year":"2012","journal-title":"J. Gen. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0304-3940(82)90421-9","article-title":"Intracellular sites of early calcium accumulation in the rat hippocampus during status epilepticus","volume":"30","author":"Griffiths","year":"1982","journal-title":"Neurosci. 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