{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:43:52Z","timestamp":1773024232999,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/23790-2"],"award-info":[{"award-number":["2015\/23790-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Membranes"],"abstract":"<jats:p>Guided bone regeneration was studied to establish protocols and develop new biomaterials that revealed satisfactory results. The present study aimed to comparatively evaluate the efficiency of the bacterial cellulose membrane (Nanoskin\u00ae) and collagen membrane Bio-Gide\u00ae in the bone repair of 8-mm critical size defects in rat calvaria. Seventy-two adult male rats were divided into three experimental groups (n = 24): the CG\u2014membrane-free control group (only blood clot, negative control), BG\u2014porcine collagen membrane group (Bio-Guide\u00ae, positive control), and BC\u2014bacterial cellulose membrane group (experimental group). The comparison periods were 7, 15, 30, and 60 days postoperatively. Histological, histometric, and immunohistochemical analyses were performed. The quantitative data were subjected to 2-way ANOVA and Tukey\u2019s post-test, and p &lt; 0.05 was considered significant. At 30 and 60 days postoperatively, the BG group showed more healing of the surgical wound than the other groups, with a high amount of newly formed bone (p &lt; 0.001), while the BC group showed mature connective tissue filling the defect. The inflammatory cell count at postoperative days 7 and 15 was higher in the BC group than in the BG group (Tukey\u2019s test, p = 0.006). At postoperative days 30 and 60, the area of new bone formed was greater in the BG group than in the other groups (p &lt; 0.001). Immunohistochemical analysis showed moderate and intense immunolabeling of osteocalcin and osteopontin at postoperative day 60 in the BG and BC groups. Thus, despite the promising application of the BC membrane in soft-tissue repair, it did not induce bone repair in rat calvaria.<\/jats:p>","DOI":"10.3390\/membranes10090230","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T21:11:32Z","timestamp":1600031492000},"page":"230","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Is the Bacterial Cellulose Membrane Feasible for Osteopromotive Property?"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-4953","authenticated-orcid":false,"given":"Ana Paula","family":"Farnezi Bassi","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University, UNESP, School of Dentistry, Ara\u00e7atuba, S\u00e3o Paulo 16015-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Ferreira","family":"Bizelli","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University, UNESP, School of Dentistry, Ara\u00e7atuba, S\u00e3o Paulo 16015-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia Freitas de Mendes","family":"Brasil","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University, UNESP, School of Dentistry, Ara\u00e7atuba, S\u00e3o Paulo 16015-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1rede Carvalho","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University, UNESP, School of Dentistry, Ara\u00e7atuba, S\u00e3o Paulo 16015-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-2408","authenticated-orcid":false,"given":"Hesham Mohammed","family":"Al-Sharani","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Dentistry, Ibb University, Ibb 16015-050, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Antonio Correa","family":"Momesso","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University, UNESP, School of Dentistry, Ara\u00e7atuba, S\u00e3o Paulo 16015-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2249-3048","authenticated-orcid":false,"given":"Leonardo P.","family":"Faverani","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, S\u00e3o Paulo State University, UNESP, School of Dentistry, Ara\u00e7atuba, S\u00e3o Paulo 16015-050, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5526-8528","authenticated-orcid":false,"given":"Flavia de Almeida","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Animal Clinic, Surgery and Reproduction, S\u00e3o Paulo State University, UNESP, School of Veterinary Medicine, Ara\u00e7atuba, S\u00e3o Paulo 16050-698, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00198-002-1340-9","article-title":"Reduced bone formation and increased bone resorption: Rational targets for the treatment of osteoporosis","volume":"14","author":"Seeman","year":"2003","journal-title":"Osteoporos. 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