{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:48:19Z","timestamp":1790621299430,"version":"4.1.0"},"reference-count":110,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Key Medical Subject","award":["No. SZXK023"],"award-info":[{"award-number":["No. SZXK023"]}]},{"name":"Shenzhen \u201cSan-Ming\u201d Project of Medicine","award":["No. SZSM201612092"],"award-info":[{"award-number":["No. SZSM201612092"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82001319"],"award-info":[{"award-number":["No. 82001319"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["No. 2019A1515011290 and 2019A1515110983"],"award-info":[{"award-number":["No. 2019A1515011290 and 2019A1515110983"]}]},{"name":"Bethune Charitable Foundation and CSPC Osteoporosis Research Foundation Project","award":["No. G-X-2020-1107-21"],"award-info":[{"award-number":["No. G-X-2020-1107-21"]}]},{"name":"Shenzhen Scientific Research Project of Health and Family Planning System","award":["No. SZXJ2018077"],"award-info":[{"award-number":["No. SZXJ2018077"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Membranes"],"abstract":"<jats:p>As an insidious metabolic bone disease, osteoporosis plagues the world, with high incidence rates. Patients with osteoporosis are prone to falls and becoming disabled, and their cone fractures and hip fractures are very serious, so the diagnosis and treatment of osteoporosis is very urgent. Extracellular vesicles (EVs) are particles secreted from cells to the outside of the cell and they are wrapped in a bilayer of phospholipids. According to the size of the particles, they can be divided into three categories, namely exosomes, microvesicles, and apoptotic bodies. The diameter of exosomes is 30\u2013150 nm, the diameter of microvesicles is 100\u20131000 nm, and the diameter of apoptotic bodies is about 50\u20135000 nm. EVs play an important role in various biological process and diseases including osteoporosis. In this review, the role of EVs in osteoporosis is systematically reviewed and some insights for the prevention and treatment of osteoporosis are provided.<\/jats:p>","DOI":"10.3390\/membranes12030324","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T02:51:51Z","timestamp":1647831111000},"page":"324","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Role of Extracellular Vesicles in Osteoporosis: A Scoping Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Weifei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Bone & Joint Surgery\/National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengzhou","family":"Huang","sequence":"additional","affiliation":[{"name":"National Cancer Center & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1586-1415","authenticated-orcid":false,"given":"Jianjing","family":"Lin","sequence":"additional","affiliation":[{"name":"Arthritis Clinical and Research Center, Peking University People\u2019s Hospital, Beijing 100044, China"},{"name":"Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Bone & Joint Surgery\/National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1001\/jama.2017.19344","article-title":"Association between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis","volume":"318","author":"Zhao","year":"2017","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1001\/jama.2018.5722","article-title":"Screening for Osteoporosis","volume":"319","author":"Cauley","year":"2018","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"114834","DOI":"10.1016\/j.jep.2021.114834","article-title":"Anti-osteoporosis effect of Semen Cuscutae in ovariectomized mice through inhibition of bone resorption by osteoclasts","volume":"285","author":"Yang","year":"2022","journal-title":"J. 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