{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:24:49Z","timestamp":1792801489672,"version":"4.5.0"},"reference-count":32,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Technology Innovation Program, the Ministry of Trade, Industry, and Energy","doi-asserted-by":"publisher","award":["20010914"],"award-info":[{"award-number":["20010914"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Technology Innovation Program, the Ministry of Trade, Industry, and Energy","doi-asserted-by":"publisher","award":["20010846"],"award-info":[{"award-number":["20010846"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Membranes"],"abstract":"<jats:p>Sterile filtration processes are widely used in the production of biotherapeutics for microorganism removal and product sterility. Sterile filtration processes can be applied to buffer preparation and cell culture media preparation in biotherapeutics processes, and to final sterilization or final filling in downstream processes. Owing to their broad range of applications in bioprocessing, various 0.2\/0.22 \u03bcm sterile filters with different polymer materials (i.e., hydrophilic PVDF and PES) and nominal pore sizes are commercially available. The objective of this study was to evaluate two different commercial sterile filters in terms of filtration performance in various sterile filtration processes of biopharmaceutical production. The results demonstrate the importance of choosing the appropriate filter considering the process type and target removal\/transport product to ensure efficient sterile filtration in the production of biotherapeutics.<\/jats:p>","DOI":"10.3390\/membranes12050524","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T21:36:06Z","timestamp":1652736966000},"page":"524","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparative Evaluation of the Performance of Sterile Filters for Bioburden Protection and Final Fill in Biopharmaceutical Processes"],"prefix":"10.3390","volume":"12","author":[{"given":"Jimin","family":"Na","sequence":"first","affiliation":[{"name":"Department of Biological Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwoo","family":"Suh","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering, College of Engineering, Institute of Chemical Process (ICP), Seoul National University (SNU), 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-1979","authenticated-orcid":false,"given":"Young Hoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Green Carbon Research Center, Korea Research Institute of Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Korea"},{"name":"Department of Advanced Materials and Chemical Engineering, University of Science & Technology (UST), Yuseong-gu, Daejeon 34113, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngbin","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.memsci.2007.02.045","article-title":"Bioprocess Membrane Technology","volume":"297","author":"Zydney","year":"2007","journal-title":"J. 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