{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:31:21Z","timestamp":1781307081435,"version":"3.54.1"},"reference-count":58,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Membranes"],"abstract":"<jats:p>Bone substitutes and barrier membranes are widely used in dental regeneration procedures. New materials are constantly being developed to provide the most optimal surgical outcomes. One of these developments is the addition of hyaluronate (HA) to the bovine bone graft, which has beneficial wound healing and handling properties. However, an acidic environment that is potentially produced by the HA is known to increase the degradation of magnesium metal. The aim of this study was to evaluate the potential risk for the addition of HA to the bovine bone graft on the degradation rate and hence the efficacy of a new biodegradable magnesium metal GBR membrane. pH and conductivity measurements were made in vitro for samples placed in phosphate-buffered solutions. These in vitro tests showed that the combination of the bovine graft with HA resulted in an alkaline environment for the concentrations that were used. The combination was also tested in a clinical setting. The use of the magnesium metal membrane in combination with the tested grafting materials achieved successful treatment in these patients and no adverse effects were observed in vivo for regenerative treatments with or without HA. Magnesium based biodegradable GBR membranes can be safely used in combination with bovine graft with or without hyaluronate.<\/jats:p>","DOI":"10.3390\/membranes13080691","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T01:09:01Z","timestamp":1690333741000},"page":"691","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation between Biodegradable Magnesium Metal GBR Membrane and Bovine Graft with or without Hyaluronate"],"prefix":"10.3390","volume":"13","author":[{"given":"Marko","family":"Bla\u0161kovi\u0107","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Faculty of Dental Medicine Rijeka, University of Rijeka, Kre\u0161imirova 40\/42, 51000 Rijeka, Croatia"},{"name":"Dental Clinic Dr. Bla\u0161kovi\u0107, Lini\u0107eva ulica 16, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorotea","family":"Bla\u0161kovi\u0107","sequence":"additional","affiliation":[{"name":"Dental Clinic Dr. Bla\u0161kovi\u0107, Lini\u0107eva ulica 16, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Botond","family":"Hangyasi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Semmelweis University, 1052 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-8529","authenticated-orcid":false,"given":"Olga Cvijanovi\u0107","family":"Peloza","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, University of Rijeka, Bra\u0107e Branchetta 20\/1, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7933-3371","authenticated-orcid":false,"given":"Matej","family":"Tomas","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-7157","authenticated-orcid":false,"given":"Marija","family":"\u010candrli\u0107","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-7199","authenticated-orcid":false,"given":"Patrick","family":"Rider","sequence":"additional","affiliation":[{"name":"Botiss Biomaterials, Ullsteinstrasse 108, 12109 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Mang","sequence":"additional","affiliation":[{"name":"Botiss Biomaterials, Ullsteinstrasse 108, 12109 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-723X","authenticated-orcid":false,"given":"\u017deljka Peri\u0107","family":"Ka\u010darevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Embriology, Pathology and Pathohistology, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4161-5645","authenticated-orcid":false,"given":"Branko","family":"Trajkovski","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Kuwait University, Safat 13110, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.5125\/jkaoms.2020.46.3.211","article-title":"Ridge Augmentation in Implant Dentistry","volume":"46","author":"Kim","year":"2020","journal-title":"J. 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