{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T18:38:24Z","timestamp":1773513504645,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Membranes"],"abstract":"<jats:p>The dialysis membrane based on a hydrophilic polymer (Hydrolink NV) was designed to enhance the movement of adsorbed water at the blood\u2013membrane interface, aiming to achieve antithrombogenic and antifouling effects. This study aimed to assess the performance and albumin loss of the Hydrolink NV dialyzer in hemodialysis (HD) and post-dilution hemodiafiltration (HDF) with different infusion flows (Qis) and compare it with the hydrophilic FX CorAL dialyzer in post-dilution HDF. A prospective study was carried out in 20 patients. Patients underwent five dialysis sessions with the same routine dialysis parameters: four sessions with the Toraylight NV 2.1 (HD, post-dilution HDF with 50, 75 or auto-substitution Qi) and one with the FX CorAL 800 (post-dilution HDF with auto-substitution Qi). The reduction ratios\u2019 (RRs\u2019) wide range of molecular weight molecules were assessed and the dialysate albumin loss was quantified. The lowest \u03b22-microglobulin, indoxyl-sulfate, and p-cresyl sulfate RR values were observed with the Toraylight NV 2.1 in HD, and they improved progressively with an increased Qi, without differences being observed between the two dialyzers in auto-substitution. A different removal profile was observed in terms of myoglobin, kFLC, prolactin, \u03b11-microglobulin, \u03b11-acid glycoprotein, and \u03bbFLC, whose RRs also improved progressively with an increased Qi but were significantly higher with the Toraylight NV than the CorAL in the same convective condition. There were significant differences in the albumin dialysate losses, with the highest value obtained with the Toraylight NV in auto-substitution HDF, with more than 50% of patients surpassing 5 g per session. The Toraylight NV dialyzer has great potential for efficacy but should be used at the optimal convective volume (Qi not exceeding 75 mL\/min or FF not exceeding 25%) to avoid excessive albumin loss.<\/jats:p>","DOI":"10.3390\/membranes15010030","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:13:07Z","timestamp":1736835187000},"page":"30","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis Membrane"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-0353","authenticated-orcid":false,"given":"Francisco","family":"Maduell","sequence":"first","affiliation":[{"name":"Nephrology and Renal Transplantation, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-207X","authenticated-orcid":false,"given":"Victor Joaqu\u00edn","family":"Escudero-Saiz","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-6911","authenticated-orcid":false,"given":"Elena","family":"Cuadrado-Pay\u00e1n","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rodriguez-Garcia","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department-CDB, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miquel","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lida Mar\u00eda","family":"Rodas","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e9stor","family":"Fontser\u00e9","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria del Carmen","family":"Salgado","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department-CDB, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3271-1371","authenticated-orcid":false,"given":"Gregori","family":"Casals","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department-CDB, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5667-0650","authenticated-orcid":false,"given":"Nayra","family":"Rico","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department-CDB, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-9083","authenticated-orcid":false,"given":"Jos\u00e9 Jes\u00fas","family":"Broseta","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12221-009-0001-4","article-title":"Improvement of hydrophilicity and blood compatibility on polyethersulfone membrane by adding polyvinylpyrrolidone","volume":"10","author":"Wang","year":"2009","journal-title":"Fibers Polym."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12895","DOI":"10.1021\/am403405c","article-title":"Antifouling and antimicrobial polymer membranes based on bioinspired polydopamine and strong hydrogen-bonded poly(N-vinyl pyrrolidone)","volume":"5","author":"Jiang","year":"2013","journal-title":"ACS Appl. 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