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Although the consumption of these compounds is generally considered safe, some studies suggest that chronically consuming L-Glu may be associated with various disorders. In this study, Wistar pregnant rats were treated daily with 1 g\/L of L-Glu in their drinking water throughout the gestational period. OPA-1, DRP-1, and mitofusin 2\u2014key proteins involved in mitochondrial fusion and fission\u2014were analyzed by Western blot. The results showed that L-Glu exposure significantly decreased DRP-1 levels, while OPA-1 and mitofusin 2 levels were unaffected. This was accompanied by a notable decrease in mitochondrial complexes III and V. The activities of Mg2+-ATPase and Na+\/K+-ATPase were also analyzed in fetal cerebellar plasma membranes. Maternal L-Glu intake significantly increased Mg2+-ATPase activity. Regarding Na+\/K+-ATPase, the data showed that L-Glu exposure did not modulate the protein level or its activity. However, a positive interaction with glutamate receptors was observed in both activities, although neither AMPA nor NMDA receptors appeared to be involved. These results suggest that chronic maternal L-Glu intake during gestation modulates Mg2+-ATPase activity and protein markers of mitochondrial dynamics in the fetal cerebellum, which could affect neonatal development.<\/jats:p>","DOI":"10.3390\/membranes15050152","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T05:11:57Z","timestamp":1747372317000},"page":"152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Membrane ATPases and Mitochondrial Proteins in Fetal Cerebellum After Exposure to L-Glutamate During Gestation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-8793","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Tejero","sequence":"first","affiliation":[{"name":"Department of Inorganic and Organic Chemistry and Biochemistry, Faculty of Chemical Sciences and Technologies, Institute of Biomedicine, Investigaci\u00f3n Sanitaria de Castilla-La Mancha, University of Castilla-La Mancha, Avenida Camilo Jos\u00e9 Cela 10, 13071 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-9237","authenticated-orcid":false,"given":"David Agust\u00edn","family":"Le\u00f3n-Navarro","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Organic Chemistry and Biochemistry, Faculty of Chemical Sciences and Technologies, Institute of Biomedicine, Investigaci\u00f3n Sanitaria de Castilla-La Mancha, University of Castilla-La Mancha, Avenida Camilo Jos\u00e9 Cela 10, 13071 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6843-3449","authenticated-orcid":false,"given":"Mairena","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Organic Chemistry and Biochemistry, Faculty of Chemical Sciences and Technologies, Institute of Biomedicine, Investigaci\u00f3n Sanitaria de Castilla-La Mancha, University of Castilla-La Mancha, Avenida Camilo Jos\u00e9 Cela 10, 13071 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"814S","DOI":"10.3945\/ajcn.2009.27462S","article-title":"Metabolism and Functions of L-Glutamate in the Epithelial Cells of the Small and Large Intestines","volume":"90","author":"Blachier","year":"2009","journal-title":"Am. 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