{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:40:46Z","timestamp":1778697646411,"version":"3.51.4"},"reference-count":45,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Membranes"],"abstract":"<jats:p>Solvents purification mainly used in pharmaceutical field such as acetone and methyl ethyl ketone (MEK) were performed through hybrid silica membranes and from binary and multi-components mixtures. Two hybrid silica membranes\u2014zirconia doped bis(triethoxysilyl)methane and bis(triethoxysilyl)ethane (BTESE)\u2014were studied. Flux, permeance, and separation factor were evaluated depending on temperature, composition, and number of organic compounds in the feed. Dehydration tests of acetone were operated at 30 and 45 \u00b0C following by acetone and MEK purification at 50 \u00b0C from multi-components hydro-organic mixtures where hydrophilic compounds (water, methanol) but also hydrophobic (dichloromethane (DCM) and\/or toluene) were present. Results showed that the presence of Zr nanoparticles affected flux and improved selectivity in the case of dehydration. Experiments related to acetone and MEK purification, revealed a mass transfer alteration and a decrease of performance, from 99 to 97 wt% and from 98 to 95 wt% respectively, when the number of compounds in the initial feed grown up and more precisely, in the presence of DCM and toluene thus highlighting a possible coupling effect.<\/jats:p>","DOI":"10.3390\/membranes9070076","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T10:54:47Z","timestamp":1561978487000},"page":"76","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes"],"prefix":"10.3390","volume":"9","author":[{"given":"Thomas","family":"La Rocca","sequence":"first","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS Centrale Marseille, M2P2 UMR 7340, Equipe Proc\u00e9d\u00e9s Membranaires (EPM), Europ\u00f4le de l\u2019Arbois, BP80, Pavillon Laennec, Hall C, 13545 Aix-en-Provence, CEDEX, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5630-0975","authenticated-orcid":false,"given":"Emilie","family":"Carretier","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS Centrale Marseille, M2P2 UMR 7340, Equipe Proc\u00e9d\u00e9s Membranaires (EPM), Europ\u00f4le de l\u2019Arbois, BP80, Pavillon Laennec, Hall C, 13545 Aix-en-Provence, CEDEX, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Dhaler","sequence":"additional","affiliation":[{"name":"C\u00e9ramiques Techniques Industrielles (CTI), 382 Avenue du Moulinas, 30340 Salindres, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Louradour","sequence":"additional","affiliation":[{"name":"C\u00e9ramiques Techniques Industrielles (CTI), 382 Avenue du Moulinas, 30340 Salindres, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thien","family":"Truong","sequence":"additional","affiliation":[{"name":"C\u00e9ramiques Techniques Industrielles (CTI), 382 Avenue du Moulinas, 30340 Salindres, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-0571","authenticated-orcid":false,"given":"Philippe","family":"Moulin","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, CNRS Centrale Marseille, M2P2 UMR 7340, Equipe Proc\u00e9d\u00e9s Membranaires (EPM), Europ\u00f4le de l\u2019Arbois, BP80, Pavillon Laennec, Hall C, 13545 Aix-en-Provence, CEDEX, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0048-9697(03)00197-9","article-title":"Ambient volatile organic compound (VOC) concentrations around a petrochemical complex and a petroleum refinery","volume":"312","author":"Cetin","year":"2003","journal-title":"Sci. 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