{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:21:02Z","timestamp":1791699662097,"version":"4.3.4"},"reference-count":69,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>The critical CO2 hydration reaction to bicarbonate and protons is catalyzed by carbonic anhydrases (CAs, EC 4.2.1.1). Their physiological role is to assist the transport of the CO2 and HCO3\u2212 at the cellular level, which will not be ensured by the low velocity of the uncatalyzed reaction. CA inhibition may impair the growth of microorganisms. In the yeasts, Candida albicans and Malassezia globosa, the activity of the unique \u03b2-CA identified in their genomes was demonstrated to be essential for growth of the pathogen. Here, we decided to investigate the sulfonamide inhibition profile of the homologous \u03b2-CA (MreCA) identified in the genome of Malassezia restricta, an opportunistic pathogen triggering dandruff and seborrheic dermatitis. Among 40 investigated derivatives, the best MreCA sulfonamide inhibitors were dorzolamide, brinzolamide, indisulam, valdecoxib, sulthiam, and acetazolamide (KI &lt; 1.0 \u03bcM). The MreCA inhibition profile was different from those of the homologous enzyme from Malassezia globosa (MgCA) and the human isoenzymes (hCA I and hCA II). These results might be useful to for designing CA inhibitor scaffolds that may selectively inhibit the dandruff-producing fungi.<\/jats:p>","DOI":"10.3390\/metabo10010039","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T07:39:02Z","timestamp":1579246742000},"page":"39","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Sulfonamide Inhibition Profile of the \u03b2-Carbonic Anhydrase from Malassezia restricta, An Opportunistic Pathogen Triggering Scalp Conditions"],"prefix":"10.3390","volume":"10","author":[{"given":"Sonia","family":"Del Prete","sequence":"first","affiliation":[{"name":"Institute of Biosciences and Bioresources, CNR, Via Pietro Castellino 111, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7192","authenticated-orcid":false,"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[{"name":"Section of Pharmaceutical and Nutraceutical Sciences, Department of Neurofarb, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Ghobril","sequence":"additional","affiliation":[{"name":"L\u2019Or\u00e9al Research and Innovation, 93601 Aulnay-sous-Bois, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Hitce","sequence":"additional","affiliation":[{"name":"L\u2019Or\u00e9al Research and Innovation, 93601 Aulnay-sous-Bois, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Clavaud","sequence":"additional","affiliation":[{"name":"L\u2019Or\u00e9al Research and Innovation, 93601 Aulnay-sous-Bois, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Marat","sequence":"additional","affiliation":[{"name":"L\u2019Or\u00e9al Research and Innovation, 93601 Aulnay-sous-Bois, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Section of Pharmaceutical and Nutraceutical Sciences, Department of Neurofarb, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-2411","authenticated-orcid":false,"given":"Clemente","family":"Capasso","sequence":"additional","affiliation":[{"name":"Institute of Biosciences and Bioresources, CNR, Via Pietro Castellino 111, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.jidsymp.5650048","article-title":"A practical guide to scalp disorders","volume":"12","author":"Grimalt","year":"2007","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Borda, L.J., and Wikramanayake, T.C. (2015). Seborrheic Dermatitis and Dandruff: A Comprehensive Review. J. Clin. Investig. 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