{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T01:00:20Z","timestamp":1780794020017,"version":"3.54.1"},"reference-count":123,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Cardiovascular disease (CVD) is the leading cause of death worldwide. There are numerous factors involved in the development of CVD. Among these, lipids have an important role in maintaining the myocardial cell structure as well as cardiac function. Fatty acids (FA) are utilized for energy, but also contribute to the pathogenesis of CVD and heart failure. Advances in mass spectrometry methods have enabled the comprehensive analysis of a plethora of lipid species from a single sample comprised of a heterogeneous population of lipid molecules. Determining cardiac lipid alterations in different models of CVD identifies novel biomarkers as well as reveals molecular mechanisms that underlie disease development and progression. This information could inform the development of novel therapeutics in the treatment of CVD. Herein, we provide a review of recent studies of cardiac lipid profiles in myocardial infarction, obesity, and diabetic and dilated cardiomyopathy models of CVD by methods of mass spectrometry analysis.<\/jats:p>","DOI":"10.3390\/metabo10060254","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T12:21:46Z","timestamp":1592482906000},"page":"254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The Cardiac Lipidome in Models of Cardiovascular Disease"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-2737","authenticated-orcid":false,"given":"Mateusz M.","family":"Tomczyk","sequence":"first","affiliation":[{"name":"Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Theme of the Children\u2019s Hospital Research Institute of Manitoba, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada"},{"name":"Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB R3E 0T6, Canada"},{"name":"Rady Faculty of Health Science, College of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-4628","authenticated-orcid":false,"given":"Vernon W.","family":"Dolinsky","sequence":"additional","affiliation":[{"name":"Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Theme of the Children\u2019s Hospital Research Institute of Manitoba, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada"},{"name":"Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB R3E 0T6, Canada"},{"name":"Rady Faculty of Health Science, College of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"ref_1","unstructured":"(2020, March 17). World Health Organization. Available online: https:\/\/www.who.int\/health-topics\/cardiovascular-diseases\/#tab=tab_1."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jacc.2018.06.046","article-title":"Impact of Lipids on Cardiovascular Health: JACC Health Promotion Series","volume":"72","author":"Ference","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"709828","DOI":"10.1155\/2014\/709828","article-title":"Formation and Regulation of Mitochondrial Membranes","volume":"2014","author":"Schenkel","year":"2014","journal-title":"Int. J. Cell Biol."},{"key":"ref_4","unstructured":"Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. (2002). The Lipid Bilayer, Garland Science."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/0002-9343(54)90365-4","article-title":"Metabolism of the human heart. II. Studies on fat, ketone and amino acid metabolism","volume":"16","author":"Bing","year":"1954","journal-title":"Am. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0008-6363(99)00263-1","article-title":"Cardiac fatty acid uptake and transport in health and disease","volume":"45","author":"Glatz","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pop.2012.11.003","article-title":"Hyperlipidemia as a Risk Factor for Cardiovascular Disease","volume":"40","author":"Nelson","year":"2013","journal-title":"Prim. Care Clin. Off. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2647865","DOI":"10.1155\/2016\/2647865","article-title":"Cardiometabolic Risk in Hyperlipidemic Men and Women","volume":"2016","author":"Leutner","year":"2016","journal-title":"Int. J. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/metabo2010019","article-title":"Mass spectrometry based lipidomics: An overview of technological platforms","volume":"2","author":"Fauland","year":"2012","journal-title":"Metabolites"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sysi-Aho, M., Koikkalainen, J., Sepp\u00e4nen-Laakso, T., Kaartinen, M., Kuusisto, J., Peuhkurinen, K., K\u00e4rkk\u00e4inen, S., Antila, M., Lauerma, K., and Reissell, E. (2011). Serum Lipidomics Meets Cardiac Magnetic Resonance Imaging: Profiling of Subjects at Risk of Dilated Cardiomyopathy. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0015744"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1161\/CIRCULATIONAHA.116.022993","article-title":"Glycerophosphocholine Metabolites and Cardiovascular Disease Risk Factors in Adolescents: A Cohort Study","volume":"134","author":"Syme","year":"2016","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1172\/JCI131838","article-title":"Machine learning reveals serum sphingolipids as cholesterol-independent biomarkers of coronary artery disease","volume":"130","author":"Poss","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1021\/acs.jproteome.9b00249","article-title":"Lipidomics Reveals Similar Changes in Serum Phospholipid Signatures of Overweight and Obese Pediatric Subjects","volume":"18","author":"Anjos","year":"2019","journal-title":"J. Proteome Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12944-018-0948-5","article-title":"Untargeted Mass Spectrometry Lipidomics identifies correlation between serum sphingomyelins and plasma cholesterol","volume":"18","author":"Zalloua","year":"2019","journal-title":"Lipids Health Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bbrc.2018.04.106","article-title":"Lipidomic insight into cardiovascular diseases","volume":"504","author":"Kohno","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1161\/CIRCULATIONAHA.114.009224","article-title":"Seeking a unique lipid signature predicting cardiovascular disease risk","volume":"129","author":"Brown","year":"2014","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.bbalip.2011.06.009","article-title":"Lipid classification, structures and tools","volume":"1811","author":"Fahy","year":"2011","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.48.1.1","article-title":"Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium","volume":"48","author":"Katz","year":"1981","journal-title":"Circ. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0898-6568(02)00041-4","article-title":"Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors","volume":"14","author":"Uhlenbrock","year":"2002","journal-title":"Cell. Signal."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1365-201X.1998.tb10703.x","article-title":"Lipid second messengers derived from glycerolipids and sphingolipids, and their role in smooth muscle function","volume":"164","author":"Ohanian","year":"1998","journal-title":"Acta Physiol. Scand."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/01.CIR.16.2.163","article-title":"Atherosclerosis and the Fat Content of the Diet","volume":"16","author":"Page","year":"1957","journal-title":"Circulation"},{"key":"ref_23","first-page":"927","article-title":"Atherosclerosis: Process, indicators, risk factors and new hopes","volume":"5","author":"Setorki","year":"2014","journal-title":"Int. J. Prev. Med."},{"key":"ref_24","first-page":"40","article-title":"Pathogenesis of atherosclerosis: A multifactorial process","volume":"7","author":"Singh","year":"2002","journal-title":"Exp. Clin. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","article-title":"Mechanisms of plaque formation and rupture","volume":"114","author":"Bentzon","year":"2014","journal-title":"Circ. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: A neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrcardio.2010.223","article-title":"Lipid parameters for measuring risk of cardiovascular disease","volume":"8","author":"Arsenault","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_28","first-page":"95","article-title":"Biochemical Markers of Myocardial Damage","volume":"27","author":"Bodor","year":"2016","journal-title":"J. Int. Fed. Clin. Chem. Lab. Med."},{"key":"ref_29","unstructured":"(2020, March 18). Lipidomics-Standards-Initiative (LSI). Available online: https:\/\/lipidomics-standards-initiative.org\/."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s42255-019-0094-z","article-title":"Lipidomics needs more standardization","volume":"1","author":"Liebisch","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_31","unstructured":"ChemAxon Marvin Was Used for Drawing and Displaying Chemical Structures. Marvin V20.11., Available online: https:\/\/chemaxon.com\/products\/marvin\/download."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCRESAHA.115.307778","article-title":"Revisiting cardiac cellular composition","volume":"118","author":"Pinto","year":"2016","journal-title":"Circ. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1161\/CIRCRESAHA.116.308139","article-title":"Recounting cardiac cellular composition","volume":"118","author":"Zhou","year":"2016","journal-title":"Circ. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/bj0700409","article-title":"Separation and composition of the phospholipids of ox heart","volume":"70","author":"Gray","year":"1958","journal-title":"Biochem. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0022-2275(20)39610-3","article-title":"Lipid composition of heart muscle homogenate","volume":"6","author":"Wheeldon","year":"1965","journal-title":"J. Lipid Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3389\/fphys.2018.01165","article-title":"Lipidomics reveals a tissue-specific fingerprint","volume":"9","author":"Pradas","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_37","first-page":"800","article-title":"The ultraviolet absorption spectra and other physical data for cardiolipin, a new phospholipid, and lecithin isolated from beef heart","volume":"35","author":"Crowe","year":"1945","journal-title":"J. Opt. Soc. Am."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0163-7827(00)00005-9","article-title":"The biosynthesis and functional role of cardiolipin","volume":"39","author":"Schlame","year":"2000","journal-title":"Prog. Lipid Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbabio.2013.10.006","article-title":"Functional role of cardiolipin in mitochondrial bioenergetics","volume":"1837","author":"Paradies","year":"2014","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1161\/01.CIR.99.4.578","article-title":"Glucose for the heart","volume":"99","author":"Depre","year":"1999","journal-title":"Circulation"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/physrev.00006.2004","article-title":"Myocardial substrate metabolism in the normal and failing heart","volume":"85","author":"Stanley","year":"2005","journal-title":"Physiol. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1023\/A:1005552106301","article-title":"Defects in activation and transport of fatty acids","volume":"22","author":"Brivet","year":"1999","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1172\/JCI99315","article-title":"Endothelial cell CD36 optimizes tissue fatty acid uptake","volume":"128","author":"Son","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.3390\/ijms14036306","article-title":"Mitochondria and Reactive Oxygen Species: Physiology and Pathophysiology","volume":"14","author":"Bolisetty","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s11906-004-0036-2","article-title":"Energy substrate metabolism in cardiac hypertrophy","volume":"6","author":"Allard","year":"2004","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1161\/RES.0000000000000097","article-title":"Assessing Cardiac Metabolism","volume":"118","author":"Taegtmeyer","year":"2016","journal-title":"Circ. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0355-7","article-title":"Mitochondrial dysfunction and oxidative stress in heart disease","volume":"51","author":"Peoples","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2217\/clp.13.13","article-title":"Role of oxidized phospholipids in cardiovascular pathology","volume":"8","author":"Allen","year":"2013","journal-title":"Clin. Lipidol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0022-2275(20)42690-2","article-title":"Isolation and identification of cholesteryl alkyl ethers from bovine cardiac muscle","volume":"9","author":"Funasaki","year":"1968","journal-title":"J. Lipid Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1194\/jlr.R300004-JLR200","article-title":"Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: A bridge to lipidomics","volume":"44","author":"Han","year":"2003","journal-title":"J. Lipid Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0090-6980(77)90135-6","article-title":"Hormone selective lipase activation in the isolated rabbit heart","volume":"13","author":"Hsueh","year":"1977","journal-title":"Prostaglandins"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/01.RES.54.3.313","article-title":"Accumulation of unesterified arachidonic acid in ischemic canine myocardium. Relationship to a phosphatidylcholine deacylation-reacylation cycle and the depletion of membrane phospholipids","volume":"54","author":"Chien","year":"1984","journal-title":"Circ. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/0006-291X(79)91281-6","article-title":"N-acylethanolamine accumulation in infarcted myocardium","volume":"90","author":"Epps","year":"1979","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1002\/jcp.25344","article-title":"Alteration in Phospholipidome Profile of Myoblast H9c2 Cell Line in a Model of Myocardium Starvation and Ischemia","volume":"231","author":"Sousa","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijcard.2016.11.127","article-title":"A metabolomics-driven approach reveals metabolic responses and mechanisms in the rat heart following myocardial infarction","volume":"227","author":"Nam","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e82922","DOI":"10.1172\/jci.insight.82922","article-title":"Increased de novo ceramide synthesis and accumulation in failing myocardium","volume":"2","author":"Ji","year":"2017","journal-title":"JCI Insight"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1021\/ac202779h","article-title":"MALDI mass spectrometric imaging of cardiac tissue following myocardial infarction in a rat coronary artery ligation model","volume":"84","author":"Menger","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s00216-018-0863-7","article-title":"Comprehensive targeted and non-targeted lipidomics analyses in failing and non-failing heart","volume":"410","author":"Halade","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/S0022-2275(20)31991-X","article-title":"Electrospray ionization mass spectrometry analyses of nuclear membrane phospholipid loss after reperfusion of ischemic myocardium","volume":"41","author":"Williams","year":"2000","journal-title":"J. Lipid Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.metabol.2019.04.011","article-title":"Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure","volume":"96","author":"Halade","year":"2019","journal-title":"Metabolism"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4161\/fly.5.3.15708","article-title":"Phospholipid homeostasis and lipotoxic cardiomyopathy","volume":"5","author":"Lim","year":"2011","journal-title":"Fly (Austin)"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"H339","DOI":"10.1152\/ajpheart.00742.2014","article-title":"Cardiac steatosis potentiates angiotensin II effects in the heart","volume":"308","author":"Glenn","year":"2015","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.numecd.2017.08.007","article-title":"Western diet increases cardiac ceramide content in healthy and hypertrophied hearts","volume":"27","author":"Butler","year":"2017","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Pakiet, A., Jakubiak, A., Mierzejewska, P., Zwara, A., Liakh, I., Sledzinski, T., and Mika, A. (2020). The Effect of a High-Fat Diet on the Fatty Acid Composition in the Hearts of Mice. Nutrients, 12.","DOI":"10.3390\/nu12030824"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Naoe, S., Tsugawa, H., Takahashi, M., Ikeda, K., and Arita, M. (2019). Characterization of Lipid Profiles after Dietary Intake of Polyunsaturated Fatty Acids Using Integrated Untargeted and Targeted Lipidomics. Metabolites, 9.","DOI":"10.3390\/metabo9100241"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bse0470069","article-title":"Regulation of mitochondrial biogenesis","volume":"47","author":"Jornayvaz","year":"2010","journal-title":"Essays Biochem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1\u03b1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3390\/metabo2020366","article-title":"Metabolomic and Lipidomic Analysis of the Heart of Peroxisome Proliferator-Activated Receptor-\u03b3 Coactivator 1-\u03b2 Knock Out Mice on a High Fat Diet","volume":"2","author":"McCombie","year":"2012","journal-title":"Metabolites"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e013050","DOI":"10.1161\/JAHA.119.013050","article-title":"Association of Circulating Ceramides With Cardiac Structure and Function in the Community: The Framingham Heart Study","volume":"8","author":"Nwabuo","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Casquel De Tomasi, L., Salom\u00e9 Campos, D.H., Grippa Sant\u2019Ana, P., Okoshi, K., Padovani, C.R., Masahiro Murata, G., Nguyen, S., Kolwicz, S.C., and Cicogna, A.C. (2018). Pathological hypertrophy and cardiac dysfunction are linked to aberrant endogenous unsaturated fatty acid metabolism. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193553"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"H269","DOI":"10.1152\/ajpheart.00604.2014","article-title":"Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction","volume":"308","author":"Lopez","year":"2015","journal-title":"Am. J. Physiol. Hear. Circ. Physiol."},{"key":"ref_72","first-page":"1","article-title":"The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction","volume":"9","author":"Luaces","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic cardiomyopathy: An update of mechanisms contributing to this clinical entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11154-010-9131-7","article-title":"Diabetic cardiomyopathy, causes and effects","volume":"11","author":"Boudina","year":"2010","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1161\/CIRCRESAHA.120.315913","article-title":"Basic Mechanisms of Diabetic Heart Disease","volume":"126","author":"Ritchie","year":"2020","journal-title":"Circ. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/bj3520079","article-title":"Diabetes-induced changes in specific lipid molecular species in rat myocardium","volume":"352","author":"Han","year":"2000","journal-title":"Biochem. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1021\/bi047773a","article-title":"Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: Identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics","volume":"44","author":"Su","year":"2005","journal-title":"Biochemistry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"16684","DOI":"10.1021\/bi051908a","article-title":"Shotgun lipidomics identifies cardiolipin depletion in diabetic myocardium linking altered substrate utilization with mitochondrial dysfunction","volume":"44","author":"Han","year":"2005","journal-title":"Biochemistry"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1210\/en.2012-1835","article-title":"Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db\/db mice","volume":"154","author":"DeMarco","year":"2013","journal-title":"Endocrinology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13098-017-0249-6","article-title":"Changes of myocardial lipidomics profiling in a rat model of diabetic cardiomyopathy using UPLC\/Q-TOF\/MS analysis","volume":"9","author":"Dong","year":"2017","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.pcad.2006.02.001","article-title":"From Left Ventricular Hypertrophy to Congestive Heart Failure: Management of Hypertensive Heart Disease","volume":"48","author":"Gradman","year":"2006","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","article-title":"Hypertrophy of the heart: A new therapeutic target?","volume":"109","author":"Frey","year":"2004","journal-title":"Circulation"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Dealmeida, A.C., Van Oort, R.J., and Wehrens, X.H. (2010). Transverse Aortic Constriction in Mice. J. Vis. Exp., 1729.","DOI":"10.3791\/1729-v"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1161\/CIRCULATIONAHA.119.039610","article-title":"Preservation of Acyl Coenzyme A Attenuates Pathological and Metabolic Cardiac Remodeling Through Selective Lipid Trafficking","volume":"139","author":"Goldenberg","year":"2019","journal-title":"Circulation"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1128\/EC.00079-13","article-title":"Physiological role of acyl coenzyme a synthetase homologs in lipid metabolism in Neurospora crassa","volume":"12","author":"Roche","year":"2013","journal-title":"Eukaryot. Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1042\/CS20160170","article-title":"Molecular mechanisms in cardiomyopathy","volume":"131","author":"Dadson","year":"2017","journal-title":"Clin. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCRESAHA.116.309396","article-title":"Dilated cardiomyopathy: Genetic determinants and mechanisms","volume":"121","author":"McNally","year":"2017","journal-title":"Circ. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1194\/jlr.M600551-JLR200","article-title":"Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure","volume":"48","author":"Sparagna","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/CIRCHEARTFAILURE.113.000744","article-title":"Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure","volume":"7","author":"Le","year":"2014","journal-title":"Circ. Hear. Fail."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.yjmcc.2014.06.002","article-title":"Dysregulation of cardiolipin biosynthesis in pediatric heart failure","volume":"74","author":"Chatfield","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/annonc\/mdf118","article-title":"Frequency and risk factors of anthracycline-induced clinical heart failure in children: A systematic review","volume":"13","author":"Kremer","year":"2002","journal-title":"Ann. Oncol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1200\/JCO.2006.10.4976","article-title":"Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer","volume":"25","author":"Pinder","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13293-015-0039-5","article-title":"Sex-specific cardiac cardiolipin remodelling after doxorubicin treatment","volume":"6","author":"Moulin","year":"2015","journal-title":"Biol. Sex. Differ."},{"key":"ref_94","first-page":"1257","article-title":"Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion","volume":"151","author":"Bielawska","year":"1997","journal-title":"Am. J. Pathol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0008-6363(99)00142-X","article-title":"Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes","volume":"43","author":"Delpy","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1023\/A:1005590316064","article-title":"Ceramide accumulation is associated with increased apoptotic cell death in cultured fibroblasts of sphingolipid activator protein-deficient mouse but not in fibroblasts of patients with Farber disease","volume":"22","author":"Tohyama","year":"1999","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1016\/j.celrep.2018.02.034","article-title":"Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy","volume":"22","author":"Walls","year":"2018","journal-title":"Cell Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/cvr\/cvq266","article-title":"Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation","volume":"89","author":"Zhang","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cmet.2007.10.013","article-title":"Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance","volume":"7","author":"Koves","year":"2008","journal-title":"Cell Metab."},{"key":"ref_100","first-page":"1","article-title":"Exercise and Cardiovascular Health Jonathan Myers","volume":"107","author":"Myers","year":"2003","journal-title":"Health Care (Don. Mills)."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1016\/j.celrep.2018.08.017","article-title":"Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets","volume":"24","author":"Tham","year":"2018","journal-title":"Cell Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/1354750X.2011.561367","article-title":"The effects of simvastatin treatment on plasma lipid-related biomarkers in men with dyslipidaemia","volume":"16","author":"Chen","year":"2011","journal-title":"Biomarkers"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1194\/jlr.P061143","article-title":"Statin action favors normalization of the plasma lipidome in the atherogenic mixed dyslipidemia of MetS: Potential relevance to statin-associated dysglycemia","volume":"56","author":"Meikle","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1185\/03007990802321709","article-title":"Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: Investigating differential effects among statins","volume":"24","author":"Bergheanu","year":"2008","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1194\/jlr.P068585","article-title":"Statin action enriches HDL3 in polyunsaturated phospholipids and plasmalogens and reduces LDL-derived phospholipid hydroperoxides in atherogenic mixed dyslipidemia","volume":"57","author":"Orsoni","year":"2016","journal-title":"J. Lipid Res."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Yetukuri, L., Huopaniemi, I., Koivuniemi, A., Maranghi, M., Hiukka, A., Nygren, H., Kaski, S., Taskinen, M.R., Vattulainen, I., and Jauhiainen, M. (2011). High density lipoprotein structural changes and drug response in lipidomic profiles following the long-term fenofibrate therapy in the FIELD substudy. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023589"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(05)67667-2","article-title":"The FIELD study investigators Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial","volume":"366","author":"Keech","year":"2005","journal-title":"Lancet"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1113\/jphysiol.2012.230490","article-title":"Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats","volume":"590","author":"Dolinsky","year":"2012","journal-title":"J. Physiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.bbalip.2016.03.008","article-title":"Cardiac mitochondrial energy metabolism in heart failure: Role of cardiolipin and sirtuins","volume":"1861","author":"Dolinsky","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3389\/fphys.2018.01042","article-title":"Berberine Could Ameliorate Cardiac Dysfunction via Interfering Myocardial Lipidomic Profiles in the Rat Model of Diabetic Cardiomyopathy","volume":"9","author":"Dong","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_111","first-page":"151","article-title":"Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes","volume":"4","author":"Gao","year":"2011","journal-title":"Mol. Med. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/aps.2009.180","article-title":"CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity","volume":"31","author":"Qi","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.amjcard.2008.02.003","article-title":"Why Have Antioxidants Failed in Clinical Trials?","volume":"101","author":"Steinhubl","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/nyas.12796","article-title":"Direct molecular targets of resveratrol: Identifying key interactions to unlock complex mechanisms","volume":"1348","author":"Britton","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.bbadis.2014.10.005","article-title":"The molecular targets of resveratrol","volume":"1852","author":"Kulkarni","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.7150\/thno.30787","article-title":"Berberine in cardiovascular and metabolic diseases: From mechanisms to therapeutics","volume":"9","author":"Feng","year":"2019","journal-title":"Theranostics"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1681\/ASN.2012121216","article-title":"The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin","volume":"24","author":"Birk","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/cvr\/cvu157","article-title":"Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease","volume":"103","author":"Eirin","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Lee, F.Y., Shao, P.L., Wallace, C.G., Chua, S., Sung, P.H., Ko, S.F., Chai, H.T., Chung, S.Y., Chen, K.H., and Lu, H.I. (2018). Combined therapy with SS31 and mitochondria mitigates myocardial ischemia-reperfusion injury in rats. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092782"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/01.mca.0000236285.71683.b6","article-title":"Potent mitochondria-targeted peptides reduce myocardial infarction in rats","volume":"18","author":"Cho","year":"2007","journal-title":"Coron. Artery Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jacc.2010.12.044","article-title":"Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy","volume":"58","author":"Dai","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1113\/jphysiol.2014.286518","article-title":"Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin-induced cardiac and skeletal muscle myopathy","volume":"593","author":"Min","year":"2015","journal-title":"J. Physiol."},{"key":"ref_123","first-page":"147","article-title":"Elamipretide Improves Mitochondrial Function in the Failing Human Heart","volume":"4","author":"Chatfield","year":"2019","journal-title":"JACC Basic Trans. Sci."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/10\/6\/254\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:40:07Z","timestamp":1760175607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/10\/6\/254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":123,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["metabo10060254"],"URL":"https:\/\/doi.org\/10.3390\/metabo10060254","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,17]]}}}