{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:44:32Z","timestamp":1791477872408,"version":"4.3.4"},"reference-count":148,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among premenopausal women. PCOS may have reproductive, metabolic, cardiovascular, and psychological implications. Vitamin D deficit is often encountered in PCOS women and may contribute to the pathophysiology of this disorder. As of the key role of vitamin D in bone and mineral metabolism, and because the vitamin D status appears to be closely linked with the PCOS manifestations including insulin resistance, obesity, ovulatory and menstrual irregularities, oxidative stress and PTH elevation, hypovitaminosis D may directly and indirectly via the different facets of PCOS impair bone health in these women. Although limited data are available on life-long fracture risk in women with PCOS, the importance of preserving bone health in youth and adults to prevent osteoporosis and related fractures is also recognized in PCOS women. Evidence of the association between vitamin D and the clinical hallmarks of PCOS are summarized and discussed. Vitamin D arises as a cornerstone in women with PCOS and contributes to the pathophysiological link between PCOS and bone metabolism.<\/jats:p>","DOI":"10.3390\/metabo11020116","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T20:56:21Z","timestamp":1613681781000},"page":"116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Vitamin D, Bone Metabolism, and Fracture Risk in Polycystic Ovary Syndrome"],"prefix":"10.3390","volume":"11","author":[{"given":"Flavia","family":"Di Bari","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Viale Gazzi, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-2299","authenticated-orcid":false,"given":"Antonino","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Viale Gazzi, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0467-4921","authenticated-orcid":false,"given":"Federica","family":"Bellone","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Viale Gazzi, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9488-2021","authenticated-orcid":false,"given":"Gabriella","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Viale Gazzi, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Benvenga","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Viale Gazzi, 98125 Messina, Italy"},{"name":"Master Program on Childhood, Adolescent and Women\u2019s Endocrine Health, University of Messina, Viale Gazzi, 98125 Messina, Italy"},{"name":"Interdepartmental Program of Molecular &amp; Clinical Endocrinology and Women\u2019s Endocrine Health, University Hospital, A.O.U. Policlinico G. Martino, Viale Gazzi, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: Definition, aetiology, diagnosis and treatment","volume":"14","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"247.e1","DOI":"10.1016\/j.ajog.2015.12.013","article-title":"Stein and Leventhal: 80 years on","volume":"214","author":"Azziz","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1210\/jc.2013-3996","article-title":"Polycystic ovary syndrome: What\u2019s in a name?","volume":"99","author":"Azziz","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.23736\/S0026-4784.19.04404-6","article-title":"Criteria, phenotypes and prevalence of polycystic ovary syndrome","volume":"71","author":"Belenkaia","year":"2019","journal-title":"Minerva Ginecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.3390\/nu7064555","article-title":"Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis","volume":"7","author":"He","year":"2015","journal-title":"Nutrients"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1530\/EJE-16-0373","article-title":"MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome","volume":"176","author":"Glintborg","year":"2017","journal-title":"Eur. J. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1056\/NEJMoa1109617","article-title":"A pooled analysis of vitamin D dose requirements for fracture prevention","volume":"367","author":"Willett","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1007\/s00198-012-2030-x","article-title":"Osteoporosis in young adults: Pathophysiology, diagnosis, and management","volume":"23","author":"Ferrari","year":"2012","journal-title":"Osteoporos. Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Atteritano, M., Mirarchi, L., Venanzi-Rullo, E., Santoro, D., Iaria, C., Catalano, A., Lasco, A., Arcoraci, V., Lo Gullo, A., and Bitto, A. (2018). Vitamin D Status and the Relationship with Bone Fragility Fractures in HIV-Infected Patients: A Case Control Study. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010119"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1007\/PL00022727","article-title":"Vitamin D metabolism and action","volume":"8","author":"Bouillon","year":"1998","journal-title":"Osteoporos. Int."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mu, Y., Cheng, D., Yin, T.L., and Yang, J. (2020). Vitamin D and Polycystic Ovary Syndrome: A Narrative Review. Reprod. Sci.","DOI":"10.1007\/s43032-020-00369-2"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.fertnstert.2014.04.046","article-title":"Role of vitamin D in ovarian physiology and its implication in reproduction: A systematic review","volume":"102","author":"Irani","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1365-2265.2012.04434.x","article-title":"D Vitamin D in the aetiology and management of polycystic ovary syndrome","volume":"77","author":"Thomson","year":"2012","journal-title":"Clin. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1530\/EJE-14-0158","article-title":"Mechanisms in endocrinology: Vitamin D as a potential contributor in endocrine health and disease","volume":"171","author":"Muscogiuri","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gr.107920.110","article-title":"A chip-seq defined genome-wide map of vitamin d receptor binding: Associations with disease and evolution","volume":"20","author":"Ramagopalan","year":"2010","journal-title":"Genome. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/nu5010111","article-title":"Vitamin D\u2014Effects on skeletal and extraskeletal health and the need for supplementation","volume":"5","author":"Wacker","year":"2013","journal-title":"Nutrients"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Li, X., Liu, Y., Zheng, Y., Wang, P., and Zhang, Y. (2018). The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis. Nutrients, 10.","DOI":"10.3390\/nu10030375"},{"key":"ref_19","first-page":"853","article-title":"Vitamin D and parameters of calcium homeostasis in inpatients with and without Type 2 diabetes mellitus","volume":"35","author":"Carnevale","year":"2012","journal-title":"J. Endocrinol. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Medrano, M., Carrillo-Cruz, E., Montero, I., and Perez-Simon, J.A. (2018). Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092663"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gembillo, G., Cernaro, V., Siligato, R., Curreri, F., Catalano, A., and Santoro, D. (2020). Protective Role of Vitamin D in Renal Tubulopathies. Metabolites, 10.","DOI":"10.3390\/metabo10030115"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1001\/archinternmed.2011.715","article-title":"Improvement of primary dysmenorrhea caused by a single oral dose of vitamin D: Results of a randomized, double-blind, placebo-controlled study","volume":"172","author":"Lasco","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/ijc.32105","article-title":"Vitamin D levels and cancer incidence in 217,244 individuals from primary health care in Denmark","volume":"145","author":"Vojdeman","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s40618-019-01057-y","article-title":"Vitamin D status and cardiovascular outcome","volume":"42","author":"Saponaro","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00223-012-9577-6","article-title":"Vitamin D reduces musculoskeletal pain after infusion of zoledronic acid for postmenopausal osteoporosis","volume":"90","author":"Catalano","year":"2012","journal-title":"Calcif. Tissue Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/SCS.0000000000002389","article-title":"Does Vitamin D3 Have an Impact on Clinical and Biochemical Parameters Related to Third Molar Surgery","volume":"27","author":"Oteri","year":"2016","journal-title":"J. Craniofacial Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/eci.12390","article-title":"Calcifediol improves lipid profile in osteopenicatorvastatin-treated postmenopausal women","volume":"45","author":"Catalano","year":"2015","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Panfili, F.M., Roversi, M., D\u2019Argenio, P., Rossi, P., Cappa, M., and Fintini, D. (2020). Possible role of vitamin D in Covid-19 infection in pediatric population. J. Endocrinol. Investig., 1\u20139. Advance online publication.","DOI":"10.1007\/s40618-020-01327-0"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/j.fertnstert.2009.09.045","article-title":"Vitamin D3 receptor is expressed in the endometrium of cycling mice throughout the estrous cycle","volume":"93","author":"Zarnani","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng0897-391","article-title":"Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning","volume":"16","author":"Yoshizawa","year":"1997","journal-title":"Nat. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E1137","DOI":"10.1210\/jc.2013-4161","article-title":"Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells","volume":"99","author":"Merhi","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1055\/s-0030-1262837","article-title":"Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells","volume":"42","author":"Parikh","year":"2010","journal-title":"Horm. Metab. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Moridi, I., Chen, A., Tal, O., and Reshef, T. (2020). The Association between Vitamin D and Anti-M\u00fcllerian Hormone: A Systematic Review and Meta-Analysis. Nutrients, 12.","DOI":"10.3390\/nu12061567"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1210\/en.2008-1555","article-title":"Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: Regulation of MIS expression by calcitriol in prostate cancer cells","volume":"150","author":"Malloy","year":"2009","journal-title":"Endocrinology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.fertnstert.2011.08.015","article-title":"D Anti-m\u00fcllerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells","volume":"96","author":"Pellatt","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yan, Y., Chen, W., Wang, J., Huang, J., Lv, J., Zhao, H., and Guo, L. (2020). Serum anti-M\u00fcllerian hormone levels are associated with low bone mineral density in premenopausal women. Biomarkers, 1\u20138. Advance online publication.","DOI":"10.1080\/1354750X.2020.1833083"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"bqaa023","DOI":"10.1210\/endocr\/bqaa023","article-title":"Roles of Vitamin D in Reproductive Systems and Assisted Reproductive Technology","volume":"161","author":"Chen","year":"2020","journal-title":"Endocrinology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1210\/er.2018-00126","article-title":"Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions","volume":"40","author":"Bouillon","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pilz, S., Zittermann, A., Obeid, R., Hahn, A., Pludowski, P., Trummer, C., Lerchbaum, E., P\u00e9rez-L\u00f3pez, F.R., Karras, S.N., and M\u00e4rz, W. (2018). The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15102241"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"545","DOI":"10.29271\/jcpsp.2020.05.545","article-title":"Polycystic Ovary Syndrome, Subfertility and Vitamin D Deficiency","volume":"30","author":"Azhar","year":"2020","journal-title":"J. Coll. Physicians. Surg. Pak."},{"key":"ref_41","first-page":"46","article-title":"Relationship of obesity with insulin resistance in polycystic ovarian syndrome","volume":"14","author":"Qazi","year":"2018","journal-title":"Pak. J. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fendo.2020.00171","article-title":"Vitamin D Deficiency Is Associated With Metabolic Risk Factors in Women With Polycystic Ovary Syndrome: A Cross-Sectional Study in Shaanxi China","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1530\/EJE-11-0134","article-title":"Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome","volume":"164","author":"Wehr","year":"2011","journal-title":"Eur. J. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.metabol.2011.03.002","article-title":"Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome","volume":"60","author":"Li","year":"2011","journal-title":"Metabolism"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1373\/clinchem.2005.052761","article-title":"Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome","volume":"51","author":"Panidis","year":"2005","journal-title":"Clin. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1007\/s00198-017-4009-0","article-title":"European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) Identification and management of patients at increased risk of osteoporotic fracture: Outcomes of an ESCEO expert consensus meeting","volume":"28","author":"Kanis","year":"2017","journal-title":"Osteoporos. Int. A J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s40618-019-01041-6","article-title":"State of the art in osteoporosis risk assessment and treatment","volume":"42","author":"Liu","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/jog.13250","article-title":"Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review","volume":"43","author":"Reis","year":"2017","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"986281","DOI":"10.1155\/2015\/986281","article-title":"The pleiotropic effects of vitamin D in gynaecological and obstetric diseases: An overview on a hot topic","volume":"2015","author":"Colonese","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.gene.2014.03.044","article-title":"Association of VDR-gene variants with factors related to the metabolic syndrome, type 2 diabetes and vitamin D deficiency","volume":"542","author":"Alkharfy","year":"2014","journal-title":"Gene"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4103\/0971-5916.166587","article-title":"Association of vitamin D receptor gene polymorphisms with polycystic ovary syndrome among Indian women","volume":"142","author":"Dasgupta","year":"2015","journal-title":"Indian J. Med. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2217\/14622416.9.6.733","article-title":"Pharmacogenetics of bone treatments: The VDR and ERalpha gene story","volume":"9","author":"Massart","year":"2008","journal-title":"Pharmacogenomics"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4274\/jcrpe.galenos.2018.2018.0074","article-title":"Pathogenesis of Thalassemia Major-associated Osteoporosis: A Review with Insights from Clinical Experience","volume":"11","author":"Gaudio","year":"2019","journal-title":"J. Clin. Res. Pediatric Endocrinol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/s41598-017-18670-7","article-title":"Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2217\/14622416.10.3.417","article-title":"Update on the pharmacogenetics of the vitamin D receptor and osteoporosis","volume":"10","author":"Gennari","year":"2009","journal-title":"Pharmacogenomics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1210\/en.2006-0692","article-title":"Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression","volume":"148","author":"Jager","year":"2007","journal-title":"Endocrinology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1055\/s-2006-948308","article-title":"Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome","volume":"114","author":"Hahn","year":"2006","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1530\/EJE-09-0432","article-title":"Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome","volume":"161","author":"Wehr","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.clnu.2011.12.010","article-title":"Low levels of 25(OH)D and insulin-resistance: 2 unrelated features or a cause\u2013effect in PCOS?","volume":"31","author":"Muscogiuri","year":"2012","journal-title":"Clin. Nutr."},{"key":"ref_60","first-page":"5","article-title":"Vitamin D and aspects of female fertility","volume":"16","author":"Voulgaris","year":"2017","journal-title":"Hormones"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1210\/jcem-67-3-460","article-title":"Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin","volume":"67","author":"Plymate","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/2042018812437355","article-title":"The effects of old, new and emerging medicines on metabolic aberrations in PCOS","volume":"3","author":"Bargiota","year":"2012","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"ref_63","first-page":"1","article-title":"Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis","volume":"351385","author":"Alvarez","year":"2012","journal-title":"Int. J. Endocrinol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1530\/EJE-13-0617","article-title":"The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: A systematic review","volume":"169","author":"Snackey","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1017\/S0954422409389301","article-title":"Vitamin D: Emerging new roles in insulin sensitivity","volume":"22","author":"Teegarden","year":"2009","journal-title":"Nutr. Res. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/humupd\/dmz020","article-title":"Negative impact of polycystic ovary syndrome on bone health: A systematic review and meta-analysis","volume":"25","author":"Piovezan","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1615735","DOI":"10.1155\/2016\/1615735","article-title":"Fracture Risk in Type 2 Diabetes: Current Perspectives and Gender Differences","volume":"2016","author":"Russo","year":"2016","journal-title":"Int. J. Endocrinol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jbmr.321","article-title":"The osteoblast: An insulin target cell controlling glucose homeostasis","volume":"26","author":"Clemens","year":"2011","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"ref_69","first-page":"359","article-title":"Calcium and vitamin D supplementation effects on metabolic factors, menstrual cycles and follicular responses in women with polycystic ovary syndrome: A systematic review and meta-analysis","volume":"10","author":"Shojaeian","year":"2019","journal-title":"Casp. J. Int. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ctcp.2012.01.005","article-title":"Therapeutic effects of calcium & vitamin D supplementation in women with PCOS","volume":"18","author":"Firouzabadi","year":"2012","journal-title":"Complement Ther. Clin. Pract."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3109\/09513590.2012.696753","article-title":"Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome","volume":"8","author":"Pal","year":"2012","journal-title":"Gynecol. Endocrinol."},{"key":"ref_72","first-page":"10","article-title":"The role of vitamin D oral supplementation in insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials","volume":"2","author":"Bajerska","year":"2018","journal-title":"Nutrients"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09513590.2019.1625881","article-title":"Effects of vitamin D supplementation in women with polycystic ovary syndrome: A review","volume":"36","author":"Menichini","year":"2020","journal-title":"Gynecol. Endocrinol."},{"key":"ref_74","first-page":"1","article-title":"Effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome: A meta-analysis of randomized controlled trials","volume":"10","author":"Wang","year":"2020","journal-title":"Gynecol. Endocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/BF03345785","article-title":"The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome","volume":"33","author":"Selimoglu","year":"2010","journal-title":"J. Endocrinol. Invest."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3389\/fendo.2020.00516","article-title":"Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions","volume":"11","author":"Aversa","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.3390\/ijms15046569","article-title":"Vitamin D: Link between osteoporosis, obesity, and diabetes?","volume":"15","author":"Bressan","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Teede, H., Deeks, A., and Moran, L. (2010). Polycystic ovary syndrome: A complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med., 8.","DOI":"10.1186\/1741-7015-8-41"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000494902","article-title":"The Role of Androgen Excess on Insulin Sensitivity in Women","volume":"53","author":"Papalou","year":"2019","journal-title":"Front. Horm. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1210\/jcem.82.10.4319","article-title":"The localization of androgen receptors in human bone","volume":"82","author":"Abu","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1530\/JOE-16-0405","article-title":"Hormonal alterations in PCOS and its influence on bone metabolism","volume":"232","author":"Krishnan","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_82","first-page":"170","article-title":"Evaluation of the association of vitamin D deficiency with gonadotropins and sex hormone in obese and non-obese women with polycystic ovary syndrome","volume":"11","year":"2014","journal-title":"Med. Glas."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1055\/s-0043-103573","article-title":"The effect of vitamin D supplementation on the androgenic profile in patients with polycystic ovary syndrome: A systematic review and meta-analysis of clinical trials","volume":"49","author":"Nadjarzade","year":"2017","journal-title":"Horm. Metab. Res."},{"key":"ref_84","first-page":"2641","article-title":"Effect of vitamin D supplementation on polycystic ovary syndrome: A meta-analysis","volume":"19","author":"Miao","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1055\/s-0042-104060","article-title":"The effects of vitamin d-k-calcium co-supplementation on endocrine, inflammation, and oxidative stress biomarkers in vitamin d-deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial","volume":"48","author":"Razavi","year":"2016","journal-title":"Horm. Metab. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1517\/14728222.2015.1101067","article-title":"Targets to treat metabolic syndrome in polycystic ovary syndrome","volume":"19","author":"Mahalingaiah","year":"2015","journal-title":"Expert Opin. Ther. Target"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1055\/a-1160-9902","article-title":"The Effects of Vitamin D on Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review","volume":"52","author":"Williams","year":"2020","journal-title":"Horm. Metab. Res."},{"key":"ref_88","unstructured":"Al-Bayyari, N., Al-Domi, H., Zayed, F., Hailat, R., and Eaton, A. (2020). Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial. Clin. Nutr., S0261-5614(20)30496."},{"key":"ref_89","unstructured":"Shi, H., Wang, T., Wang, Q., Lin, L., Zhao, Z., Wang, Z., and Hu, Y. (2020). Relationship between vitamin D levels and oxidative stress indicators and related inflammatory factors in patients with polycystic ovary syndrome. Minerva Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tem.2019.01.005","article-title":"Implications and Future Perspectives of AGEs in PCOS Pathophysiology","volume":"30","author":"Merhi","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00418-006-0265-3","article-title":"Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries","volume":"127","author":"Piperi","year":"2007","journal-title":"Histochem. Cell Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1365-2265.2008.03247.x","article-title":"Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS)","volume":"69","author":"Katsikis","year":"2008","journal-title":"Clin. Endocrinol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s10815-017-1011-6","article-title":"Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS","volume":"34","author":"Garg","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"105521","DOI":"10.1016\/j.jsbmb.2019.105521","article-title":"Effects of vitamin D on steroidogenesis, reactive oxygen species production, and enzymatic antioxidant defense in human granulosa cells of normal and polycystic ovaries","volume":"197","author":"Masjedi","year":"2020","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/j.fertnstert.2015.07.325","article-title":"Vitamin D attenuates the adverse effect of advanced glycation end products on human granulosa cells: Implications for women with PCOS","volume":"104","author":"Merhi","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1016\/j.fertnstert.2016.07.224","article-title":"Special research presentation: Vitamin D reverses the adverse effects of advanced glycation end products on granulosa cells","volume":"106","author":"Merhi","year":"2016","journal-title":"Fertil. Steril."},{"key":"ref_97","first-page":"7608964","article-title":"Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility","volume":"2020","author":"Cairoli","year":"2020","journal-title":"J. Diabetes Res."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Corrado, A., Cici, D., Rotondo, C., Maruotti, N., and Cantatore, F.P. (2020). Molecular Basis of Bone Aging. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103679"},{"key":"ref_99","first-page":"713","article-title":"Vitamins D3 and K2 may partially counterbalance the detrimental effects of pentosidine in ex vivo human osteoblasts","volume":"30","author":"Sanguineti","year":"2016","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1210\/jc.2003-031398","article-title":"A The relationship between obesity and serum 1,25-dihydroxy-vitamin D concentrations in healthy adults","volume":"89","author":"Parikh","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1381\/096089204772787211","article-title":"Calcium metabolism in the morbidly obese","volume":"14","author":"Hamoui","year":"2004","journal-title":"Obes. Surg."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0306-9877(03)00227-5","article-title":"PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight","volume":"61","author":"McCarthy","year":"2004","journal-title":"Med. Hypotheses"},{"key":"ref_103","first-page":"430","article-title":"Vitamin D and calcium dysregulation in the polycystic ovarian syndrome","volume":"6","author":"Donovan","year":"1999","journal-title":"Steroids"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"176","DOI":"10.23736\/S0391-1977.18.02824-9","article-title":"Associations between vitamin D levels and polycystic ovary syndrome phenotypes","volume":"44","author":"Davis","year":"2019","journal-title":"Minerva Endocrinol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","article-title":"Pathogenesis of osteoporosis: Concepts, conflicts, and prospects","volume":"115","author":"Raisz","year":"2005","journal-title":"J. Clin. Invest."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00198-010-1222-5","article-title":"Adrenal effects of teriparatide in the treatment of severe postmenopausal osteoporosis","volume":"22","author":"Lasco","year":"2011","journal-title":"Osteoporos. Int."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-014-9853-8","article-title":"Higher circulating parathormone is associated with smaller and weaker bones in obese children","volume":"95","author":"Radetti","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/jbmr.2737","article-title":"Fracture Risk Is Decreased in Women with Polycystic Ovary Syndrome: A Register-Based and Population-Based Cohort Study","volume":"31","author":"Rubin","year":"2016","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00774-017-0894-8","article-title":"Increased risk of fractures in patients with polycystic ovary syndrome: A nationwide population-based retrospective cohort study","volume":"36","author":"Yang","year":"2018","journal-title":"J. Bone Miner. Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1001\/archinte.164.10.1108","article-title":"Bone mineral density thresholds for pharmacological intervention to prevent fractures","volume":"164","author":"Siris","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s007740170029","article-title":"Relationship between bone mineral density and insulin resistance in polycystic ovary syndrome","volume":"19","author":"Topcu","year":"2001","journal-title":"J. Bone Miner. Metab."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s40618-014-0175-5","article-title":"Bone mineral density in women with polycystic ovary syndrome","volume":"37","author":"Katulski","year":"2014","journal-title":"J. Endocrinol. Investig."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1038\/s41598-017-03685-x","article-title":"Competing Factors Link to Bone Health in Polycystic Ovary Syndrome: Chronic Low-Grade Inflammation Takes a Toll","volume":"7","author":"Kalyan","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/09513590.2016.1250256","article-title":"Determinants of low bone mineral density in premenopausal polycystic ovary syndrome patients","volume":"33","author":"Yoldemir","year":"2017","journal-title":"Gynecol. Endocrinol."},{"key":"ref_115","first-page":"261","article-title":"Polycystic ovary syndrome in university students: Occurrence and associated factors","volume":"8","author":"Attlee","year":"2014","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/humrep\/16.6.1255","article-title":"Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome","volume":"16","author":"Kirchengast","year":"2001","journal-title":"Hum. Reprod."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2265.1998.3691182.x","article-title":"Effect of hyperandrogenism and menstrual cycle abnormalities on bone mass and bone turnover in young women","volume":"48","author":"Adami","year":"1998","journal-title":"Clin. Endocrinol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejogrb.2004.01.031","article-title":"The association of bone mineral density with insulin resistance in patients with polycystic ovary syndrome","volume":"115","author":"Noyan","year":"2004","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0015-0282(99)00203-4","article-title":"Bone mineral density and body composition in lean women with polycystic ovary syndrome","volume":"72","author":"Good","year":"1999","journal-title":"Fertil. Steril."},{"key":"ref_120","first-page":"460","article-title":"Plasma osteoprotegerin is associated with testosterone levels but unaffected by pioglitazone treatment in patients with polycystic ovary syndrome","volume":"36","author":"Glintborg","year":"2013","journal-title":"J. Endocrinol. Investig."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/dmrr.2767","article-title":"The relationships of irisin with bone mineral density and body composition in PCOS patients","volume":"32","author":"Gao","year":"2016","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jocd.2016.10.007","article-title":"Women With Polycystic Ovary Syndrome Have Comparable Hip Bone Geometry to Age-Matched Control Women","volume":"21","author":"McBreairty","year":"2018","journal-title":"J. Clin. Densitom. Off. J. Int. Soc. Clin. Densitom."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2265.2012.04378.x","article-title":"Body composition, bone mineral density and fractures in late postmenopausal women with polycystic ovary syndrome\u2014A long-term follow-up study","volume":"77","author":"Schmidt","year":"2012","journal-title":"Clin. Endocrinol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"S709","DOI":"10.1007\/s00198-016-3748-7","article-title":"Vitamin D status in Polycystic Ovarian Women: Case-Control Study. IOF Regionals Singapore 6th Asia-Pacific Osteoporosis Meeting","volume":"27","author":"Albaik","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00774-013-0560-8","article-title":"Association of plasma GDF-9 or GDF-15 levels with bone parameters in polycystic ovary syndrome","volume":"33","author":"Berberoglu","year":"2015","journal-title":"J. Bone Miner. Metab."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1093\/humrep\/deq149","article-title":"Augmentation of cortical bone mineral density in women with polycystic ovary syndrome: A peripheral quantitative computed tomography (pQCT) study","volume":"25","author":"Kassanos","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1530\/EJE-09-0398","article-title":"Correlates of increased lean muscle mass in women with polycystic ovary syndrome","volume":"161","author":"Carmina","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1210\/jc.2007-2249","article-title":"Association of pioglitazone treatment with decreased bone mineral density in obese premenopausal patients with polycystic ovary syndrome: A randomized, placebo-controlled trial","volume":"93","author":"Glintborg","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00774-010-0211-2","article-title":"Serum concentrations of carboxylated osteocalcin are increased and associated with several components of the polycystic ovarian syndrome","volume":"29","author":"Livadas","year":"2011","journal-title":"J. Bone Miner. Metab."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/cen.13456","article-title":"Bone markers in polycystic ovary syndrome: A multicentre study","volume":"87","author":"Lingaiah","year":"2017","journal-title":"Clin. Endocrinol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1757-2215-6-4","article-title":"Serum under-carboxylated osteocalcin levels in women with polycystic ovary syndrome: Weight-dependent relationships with endocrine and metabolic traits","volume":"6","author":"Pepene","year":"2013","journal-title":"J. Ovarian Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1017\/S0033291718002076","article-title":"Depression, anxiety and perceived stress in women with and without PCOS: A community-based study","volume":"49","author":"Damone","year":"2019","journal-title":"Psychol. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.clnesp.2017.11.011","article-title":"Association between mental disorders, cognitive disturbances and vitamin D serum level: Current state","volume":"23","author":"Lerner","year":"2018","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1001\/archinternmed.2010.173","article-title":"Vitamin D and risk of cognitive decline in elderly persons","volume":"170","author":"Llewellyn","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Bigman, G. (2020). Vitamin D metabolites, D3 and D2, and their independent associations with depression symptoms among adults in the United States. Nutr. Neurosci., 1\u20139. Advance online publication.","DOI":"10.1080\/1028415X.2020.1794422"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"K\u00f6hnke, C., Herrmann, M., and Berger, K. (2020). Associations of major depressive disorder and related clinical characteristics with 25-hydroxyvitamin D levels in middle-aged adults. Nutr. Neurosci., 1\u201310. Advance online publication.","DOI":"10.1080\/1028415X.2020.1843892"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"172971","DOI":"10.1016\/j.pbb.2020.172971","article-title":"Cholecalciferol abolishes depressive-like behavior and hippocampal glucocorticoid receptor impairment induced by chronic corticosterone administration in mice","volume":"196","author":"Camargo","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Bakhtiari-Dovvombaygi, H., Izadi, S., Zare Moghaddam, M., Hashemzehi, M., Hosseini, M., Azhdari-Zarmehri, H., Dinpanah, H., and Beheshti, F. (2020). Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and neuroinflammation in rats. Naunyn-Schmiedeberg\u2019s Arch. Pharmacol., Advance online publication.","DOI":"10.1007\/s00210-020-02002-0"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/da.23025","article-title":"The effect of vitamin D supplement on negative emotions: A systematic review and meta-analysis","volume":"37","author":"Cheng","year":"2020","journal-title":"Depress. Anxiety"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/09513590.2014.975682","article-title":"Vitamin D is independently associated with depression in overweight women with and without PCOS","volume":"31","author":"Moran","year":"2015","journal-title":"Gynecol. Endocrinol. Off. J. Int. Soc. Gynecol. Endocrinol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1001\/archinte.167.21.2329","article-title":"Premenopausal, Osteoporosis Women, Alendronate, Depression (POWER) Study Group Low bone mass in premenopausal women with depression","volume":"167","author":"Eskandari","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/GME.0000000000001123","article-title":"Anxiety levels predict fracture risk in postmenopausal women assessed for osteoporosis","volume":"25","author":"Catalano","year":"2018","journal-title":"Menopause"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s11739-011-0628-1","article-title":"Bone mineral density, quantitative ultrasound parameters and bone metabolism in postmenopausal women with depression","volume":"8","author":"Atteritano","year":"2013","journal-title":"Intern. Emerg. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e4912","DOI":"10.1097\/MD.0000000000004912","article-title":"The incidence and risk of osteoporosis in patients with anxiety disorder: A Population-based retrospective cohort study","volume":"95","year":"2016","journal-title":"Medicine"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12603-012-0418-0","article-title":"Serum 25-hydroxyvitamin D levels and the risk of depression: A systematic review and meta-analysis","volume":"17","author":"Ju","year":"2013","journal-title":"J. Nutr. Health Aging"},{"key":"ref_146","unstructured":"Martino, G., Catalano, A., Bellone, F., Sardella, A., Lasco, C., Capr\u00ec, T., Langher, V., Caputo, A., Fabio, R.A., and Morabito, N. (2018). Vitamin D status is associated with anxiety levels in postmenopausal women evaluated for osteoporosis. Mediterr. J. Clin. Psychol., 6."},{"key":"ref_147","unstructured":"Martino, G., Catalano, A., Bellone, F., Langher, V., Lasco, C., Penna, A., Nicocia, G., and Morabito, N. (2018). Quality of life in postmenopausal women: Which role for vitamin D?. Mediterr. J. Clin. Psychol., 6."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.3389\/fpsyg.2019.01779","article-title":"As Time Goes by: Anxiety Negatively Affects the Perceived Quality of Life in Patients With Type 2 Diabetes of Long Duration","volume":"10","author":"Martino","year":"2019","journal-title":"Front. Psychol."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/11\/2\/116\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:25:43Z","timestamp":1760160343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/11\/2\/116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":148,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["metabo11020116"],"URL":"https:\/\/doi.org\/10.3390\/metabo11020116","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,18]]}}}