{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:43:34Z","timestamp":1760402614213,"version":"build-2065373602"},"reference-count":65,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Dentistry University of Debrecen Research Fund","award":["GINOP-2.3.2.15-2016-0001"],"award-info":[{"award-number":["GINOP-2.3.2.15-2016-0001"]}]},{"name":"Hungarian Brain Research Program","award":["2017-1.2.1-NKP-2017-00002 NKFIH-SNN-132999"],"award-info":[{"award-number":["2017-1.2.1-NKP-2017-00002 NKFIH-SNN-132999"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Osteopontin (OPN), a multifunctional phosphoglycoprotein also presents in saliva, plays a crucial role in tumour progression, inflammation and mucosal protection. Mucosal barrier injury due to high-dose conditioning regimen administered during autologous and allogeneic peripheral stem cell transplantation (APSCT) has neither efficient therapy nor established biomarkers. Our aim was to assess the biomarker role of OPN during APSCT, with primary focus on oral mucositis (OM). Serum and salivary OPN levels were determined by ELISA in 10 patients during APSCT at four stages of transplantation (day \u22123\/\u22127, 0, +7, +14), and in 23 respective healthy controls. Results: There was a negative correlation between both salivary and serum OPN levels and grade of OM severity during APSCT (r = \u22120.791, p = 0.019; r = \u22120.973, p = 0.001). Salivary OPN increased at days +7 (p = 0.011) and +14 (p = 0.034) compared to controls. Among patients, it was higher at day +14 compared to the time of admission (day \u22123\/\u22127) (p = 0.039) and transplantation (day 0) (p = 0.011). Serum OPN remained elevated at all four stages of transplantation compared to controls (p = 0.013, p = 0.02, p = 0.011, p = 0.028). During APSCT elevated salivary OPN is a potential non-invasive biomarker of oral mucositis whereas the importance of high serum OPN warrants further studies.<\/jats:p>","DOI":"10.3390\/metabo11040208","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T09:57:04Z","timestamp":1617098224000},"page":"208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Salivary Osteopontin as a Potential Biomarker for Oral Mucositis"],"prefix":"10.3390","volume":"11","author":[{"given":"Enik\u0151","family":"Gebri","sequence":"first","affiliation":[{"name":"Department of Dentoalveolar Surgery and Dental Outpatient Care, Faculty of Dentistry, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Transplantation Centre, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1170-6274","authenticated-orcid":false,"given":"Ferenc","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-7942","authenticated-orcid":false,"given":"Tibor","family":"Hortob\u00e1gyi","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Szeged, \u00c1llom\u00e1s utca 1, H-6725 Szeged, Hungary"},{"name":"MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary"},{"name":"Institute of Psychiatry Psychology and Neuroscience, King\u2019s College London, De Crespigny Park, London SE5 8AF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.oooo.2013.07.013","article-title":"Oral mucosal immunity","volume":"116","author":"Feller","year":"2013","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Gebri, E., Kov\u00e1cs, Z., M\u00e9sz\u00e1ros, B., T\u00f3th, F., Simon, \u00c1., Jankovics, H., Vonderviszt, F., Kiss, A., Guttman, A., and Hortob\u00e1gyi, T. (2020). N-Glycosylation Alteration of Serum and Salivary Immunoglobulin A Is a Possible Biomarker in Oral Mucositis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061747"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-72592-5","article-title":"Female sex as an independent prognostic factor in the development of oral mucositis during autologous peripheral stem cell transplantation","volume":"10","author":"Gebri","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Meszaros, B., Kovacs, Z., Gebri, E., Jankovics, H., Vonderviszt, F., Kiss, A., Simon, A., Botka, S., Hortobagyi, T., and Guttman, A. (2020). N-glycomic analysis of Z(IgA1) partitioned serum and salivary immunoglobulin A by capillary electrophoresis. Curr. Mol. Med., 20.","DOI":"10.2174\/1566524020666200413114151"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.14748\/bmr.v9.132","article-title":"The function of salivary proteins and the regulation of their secretion by salivary glands","volume":"9","author":"Proctor","year":"1998","journal-title":"Biomed. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"L\u00f3pez, J.P. (2020). Special Issue \u201cSaliva and Oral Diseases\u201d. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061955"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sapkota, D., S\u00f8land, T.M., Galtung, H.K., Sand, L.P., Giannecchini, S., To, K.K.W., Mendes-Correa, M.C., Giglio, D., Hasseus, B., and Braz-Silva, P.H. (2020). COVID-19 salivary signature: Diagnostic and research opportunities. J. Clin. Pathol.","DOI":"10.1136\/jclinpath-2020-206834"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Khan, R.S., Khurshid, Z., Akhbar, S., and Moin, S.F. (2016). Advances of salivary proteomics in oral squamous cell carcinoma (OSCC) detection: An update. Proteomes, 4.","DOI":"10.3390\/proteomes4040041"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.7150\/jca.20480","article-title":"Osteopontin-a promising biomarker for cancer therapy","volume":"8","author":"Wei","year":"2017","journal-title":"J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4049098","DOI":"10.1155\/2017\/4049098","article-title":"Osteopontin at the Crossroads of Inflammation and Tumor Progression","volume":"2017","author":"Castello","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-0714.1999.tb02004.x","article-title":"Osteopontin (OPN) distribution in premalignant and malignant lesions of oral epithelium and expression in cell lines derived from squamous cell carcinoma of the oral cavity","volume":"28","author":"Devoll","year":"2007","journal-title":"J. Oral Pathol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/0973-029X.203764","article-title":"Immunolocalization of osteopontin in dysplasias and squamous cell carcinomas arising from oral epithelium","volume":"21","author":"Aravind","year":"2017","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2141.2006.06218.x","article-title":"Osteopontin: A bridge between bone and blood","volume":"134","author":"Haylock","year":"2006","journal-title":"Br. J. Haematol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.matbio.2014.03.001","article-title":"Role of osteopontin in the pathophysiology of cancer","volume":"37","author":"Shevde","year":"2014","journal-title":"Matrix Biol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sampayo-Escobar, V., Green, R., Cheung, M.B., Bedi, R., Mohapatra, S., and Mohapatra, S.S. (2018). Osteopontin plays a pivotal role in increasing severity of respiratory syncytial virus infection. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0192709"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1177\/154405910608500503","article-title":"Osteopontin and mucosal protection","volume":"85","author":"Sodek","year":"2006","journal-title":"J. Dent. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/bmt.2008.299","article-title":"The Prospective oral mucositis audit: Relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning chemotherapy and autologous SCT","volume":"43","author":"McCann","year":"2009","journal-title":"Bone Marrow Transplant."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/sj.bmt.1702447","article-title":"Mucosal barrier injury: Biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: An overview","volume":"25","author":"Blijlevens","year":"2000","journal-title":"Bone Marrow Transplant."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tranon.2018.01.014","article-title":"Risk Stratification of Oral Potentially Malignant Disorders in Fanconi Anemia Patients Using Autofluorescence Imaging and Cytology-On-A Chip Assay","volume":"11","author":"Abram","year":"2018","journal-title":"Transl. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Grubbs, J.B., Exline, J.J., McCain, J., Campbell, W.K., and Twenge, J.M. (2019). Emerging adult reactions to labeling regarding age-group differences in narcissism and entitlement. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0215637"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3324\/haematol.2017.181339","article-title":"Melphalan 140 mg\/m2 or 200 mg\/m2 for autologous transplantation in myeloma: Results from the collaboration to collect autologous transplant outcomes in Lymphoma and Myeloma (CALM) study. A report by the EBMT chronic malignancies working party","volume":"103","author":"Auner","year":"2018","journal-title":"Haematologica"},{"key":"ref_22","first-page":"6141845","article-title":"Protein-Based salivary profiles as novel biomarkers for oral diseases","volume":"2018","author":"Bravo","year":"2018","journal-title":"Dis. Markers"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/172460081002500307","article-title":"Comparison between plasma and serum osteopontin levels: Usefulness in diagnosis of epithelial malignant pleural mesothelioma","volume":"25","author":"Cristaudo","year":"2010","journal-title":"Int. J. Biol. Markers"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2739\/kurumemedj.57.73","article-title":"The Interaction between Female Sex Hormone Receptors and Osteopontin in a Rat Hyperoxaluric Model","volume":"57","author":"Miyajima","year":"2010","journal-title":"Kurume Med. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00198-009-1107-7","article-title":"Increased serum osteopontin is a risk factor for osteoporosis in menopausal women","volume":"21","author":"Chang","year":"2010","journal-title":"Osteoporos Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3346\/jkms.2013.28.10.1496","article-title":"High Serum Osteopontin Levels Are Associated with Low Bone Mineral Density in Postmenopausal Women","volume":"28","author":"Cho","year":"2013","journal-title":"J. Korean Med. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1073\/pnas.96.14.8156","article-title":"Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption","volume":"96","author":"Yoshitake","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"257","DOI":"10.32007\/jfacmedbagdad.573376","article-title":"Serum Osteocalcin and Serum Osteopontin Levels in Osteoporotic Postmenopausal Women with and without Vertebral Fractures","volume":"57","author":"Mohammed","year":"2015","journal-title":"J. Fac. Med. Baghdad"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1182\/blood-2004-11-4422","article-title":"Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells","volume":"106","author":"Nilsson","year":"2005","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1089\/scd.2010.0038","article-title":"Hematopoietic stem cells are coordinated by the molecular cues of the endosteal niche","volume":"19","author":"Figdor","year":"2010","journal-title":"Stem Cells Dev."},{"key":"ref_31","first-page":"1","article-title":"Murine hematopoietic stem cell reconstitution potential is maintained by osteopontin during aging","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1365-2141.2003.04589.x","article-title":"Enhanced production of osteopontin in multiple myeloma: Clinical and pathogenic implications","volume":"123","author":"Saeki","year":"2003","journal-title":"Br. J. Haematol."},{"key":"ref_33","first-page":"174","article-title":"Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma","volume":"89","author":"Standal","year":"2004","journal-title":"Haematologica"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.bbrc.2005.05.203","article-title":"Osteopontin is upregulated by BCR-ABL","volume":"333","author":"Flamant","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.4081\/hr.2019.7964","article-title":"Osteopontin expression and its relationship with prognostic factors in diffuse large b-cell lymphoma","volume":"11","author":"Barranco","year":"2019","journal-title":"Hematol Rep."},{"key":"ref_36","first-page":"275","article-title":"Prognostic significance of osteopontin in acute myeloid leukemia: A meta-analysis","volume":"7","author":"Chen","year":"2017","journal-title":"Mol. Clin. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1182\/blood-2012-12-475483","article-title":"Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy","volume":"121","author":"Boyerinas","year":"2013","journal-title":"Blood"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"111405","DOI":"10.18632\/oncotarget.22808","article-title":"A Molecular Signature of Dormancy in CD34 + CD38-Acute Myeloid Leukaemia Cells","volume":"8","author":"Brindle","year":"2017","journal-title":"Oncotarget"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1365-2141.2008.07082.x","article-title":"Marrow osteopontin level as a prognostic factor in acute myeloid leukaemia","volume":"141","author":"Lee","year":"2008","journal-title":"Br. J. Haematol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1679\/aohc.69.181","article-title":"The expression and localization of osteopontin in the mouse major salivary glands","volume":"69","author":"Asaka","year":"2006","journal-title":"Arch. Histol. Cytol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10735-006-9031-z","article-title":"Distinct immunohistochemical expression of osteopontin in the adult rat major salivary glands","volume":"37","author":"Gassler","year":"2006","journal-title":"J. Mol. Histol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1091\/mbc.3.10.1169","article-title":"Expression and distribution of osteopontin in human tissues: Widespread association with luminal epithelial surfaces","volume":"3","author":"Brown","year":"1992","journal-title":"Mol. Biol. Cell."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.archoralbio.2004.07.012","article-title":"Relationships between age, drugs, oral sensorial complaints and salivary profile","volume":"50","author":"Nagler","year":"2005","journal-title":"Arch. Oral. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1902\/jop.2015.150399","article-title":"Associations Between Salivary Bone Metabolism Markers and Periodontal Breakdown","volume":"87","author":"Gursoy","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1677\/joe.0.1800055","article-title":"Estrogen receptor-\u03b2 is the predominant estrogen receptor subtype in human oral epithelium and salivary glands","volume":"180","author":"Savolainen","year":"2004","journal-title":"J. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1095\/biolreprod62.5.1315","article-title":"Progesterone Modulation of Osteopontin Gene Expression in the Ovine Uterus1","volume":"62","author":"Johnson","year":"2000","journal-title":"Biol. Reprod."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1095\/biolreprod.103.020651","article-title":"Osteopontin: Roles in Implantation and Placentation","volume":"69","author":"Johnson","year":"2003","journal-title":"Biol. Reprod."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/0271678X19836412","article-title":"Plasma osteopontin may predict neuroinflammation and the severity of pediatric traumatic brain injury","volume":"40","author":"Gao","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1073\/pnas.87.12.4473","article-title":"Osteopontin\u2013A possible anchor of osteoclasts to bone","volume":"87","author":"Reinholt","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1126\/science.287.5454.860","article-title":"Eta-1 (osteopontin): An early component of type-1 (cell-mediated) immunity","volume":"287","author":"Ashkar","year":"2000","journal-title":"Science"},{"key":"ref_51","first-page":"1005","article-title":"Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations","volume":"152","author":"Vaalamo","year":"1998","journal-title":"Am. J. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/s41409-018-0092-x","article-title":"Biomarkers in chronic graft-versus-host disease: Quo vadis?","volume":"53","author":"Wolff","year":"2018","journal-title":"Bone Marrow Transplant."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S417","DOI":"10.1016\/j.bbmt.2015.11.955","article-title":"Plasma osteopontin is a biomarker specifically associated with bronchiolitis obliterans syndrome after HCT","volume":"22","author":"Williams","year":"2016","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1590\/S1679-45082014AO2974","article-title":"Histopathologic diagnosis of chronic graft-versus-host disease of the oral mucosa according to the National Institutes of Health Consensus","volume":"12","author":"Coracin","year":"2014","journal-title":"Einstein"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/odi.12866","article-title":"Early salivary changes in multiple myeloma patients undergoing autologous HSCT","volume":"24","author":"Proctor","year":"2018","journal-title":"Oral Dis."},{"key":"ref_56","first-page":"82","article-title":"Assessment of salivary flow rate and secretory immunoglobulin A and oral mucosal changes in acute myeloid leukemia before and after the induction phase of chemotherapy","volume":"21","author":"Rafid","year":"2009","journal-title":"J. Baghdad Coll. Dent."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Degirmencioglu, S. (2018). The role of osteopontin expression in the prognosis of Malignant Melanoma. Nov. Approaches Cancer Study.","DOI":"10.31031\/NACS.2018.01.000511"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cncr.10709","article-title":"Plasma osteopontin","volume":"95","author":"Hotte","year":"2002","journal-title":"Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1016\/j.ijrobp.2016.06.210","article-title":"Independent Adverse Prognosis of Elevated Serum LDH in Human Papillomavirus\u2013Related Oropharyngeal Cancer","volume":"96","author":"Huang","year":"2016","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"van leeuwen, S.J.M., Proctor, G.B., Laheij, A.M.G.A., Potting, C.J.M., Smits, O., Bronkhorst, E.M., Hazenberg, M.D., Haverman, T.M., Brennan, M.T., and von B\u00fcltzingsl\u00f6wen, I. (2021). Significant salivary changes in relation to oral mucositis following autologous hematopoietic stem cell transplantation. Bone Marrow Transplant.","DOI":"10.1038\/s41409-020-01185-7"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Basile, D., Di Nardo, P., Corvaja, C., Garattini, S.K., Pelizzari, G., Lisanti, C., Bortot, L., Da Ros, L., Bartoletti, M., and Borghi, M. (2019). Mucosal injury during Anti-Cancer treatment: From pathobiology to bedside. Cancers, 11.","DOI":"10.3390\/cancers11060857"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1182\/blood-2014-02-514778","article-title":"Conditioning regimens for hematopoietic cell transplantation: One size does not fit all","volume":"124","author":"Gyurkocza","year":"2014","journal-title":"Blood"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3324\/haematol.10232","article-title":"Mucositis in patients with hematologic malignancies: An overview","volume":"92","author":"Niscola","year":"2007","journal-title":"Haematologica"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1056\/NEJMra1703472","article-title":"Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets","volume":"377","author":"Zeiser","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4103\/0973-029X.99083","article-title":"The use of salivary cytokines as a screening tool for oral squamous cell carcinoma: A review of the literature","volume":"16","author":"Osman","year":"2012","journal-title":"J. Oral Maxillofac. Pathol."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/11\/4\/208\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:55:39Z","timestamp":1760363739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/11\/4\/208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,30]]},"references-count":65,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["metabo11040208"],"URL":"https:\/\/doi.org\/10.3390\/metabo11040208","relation":{},"ISSN":["2218-1989"],"issn-type":[{"type":"electronic","value":"2218-1989"}],"subject":[],"published":{"date-parts":[[2021,3,30]]}}}