{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:52:56Z","timestamp":1792000376005,"version":"4.4.0"},"reference-count":71,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Metabolomics is a branch of \u2018omics\u2019 sciences that utilises a couple of analytical tools for the identification of small molecules (metabolites) in a given sample. The overarching goal of metabolomics is to assess these metabolites quantitatively and qualitatively for their diagnostic, therapeutic, and prognostic potentials. Its use in various aspects of life has been documented. We have also published, howbeit in animal models, a few papers where metabolomic approaches were used in the study of metabolic disorders, such as metabolic syndrome, diabetes, and obesity. As the goal of every research is to benefit humankind, the purpose of this review is to provide insights into the applicability of metabolomics in medicine vis-\u00e0-vis its role in biomarker discovery for disease diagnosis and management. Here, important biomarkers with proven diagnostic and therapeutic relevance in the management of disease conditions, such as Alzheimer\u2019s disease, dementia, Parkinson\u2019s disease, inborn errors of metabolism (IEM), diabetic retinopathy, and cardiovascular disease, are noted. The paper also discusses a few reasons why most metabolomics-based laboratory discoveries are not readily translated to the clinic and how these could be addressed going forward.<\/jats:p>","DOI":"10.3390\/metabo11070418","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T04:46:57Z","timestamp":1624596417000},"page":"418","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":157,"title":["Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases"],"prefix":"10.3390","volume":"11","author":[{"given":"Adewale Victor","family":"Aderemi","sequence":"first","affiliation":[{"name":"Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK"},{"name":"Department of Medical Biochemistry, Osun State University, Osogbo PMB 4494, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademola Olabode","family":"Ayeleso","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Adeleke University, Ede PMB 250, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluboade Oluokun","family":"Oyedapo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Obafemi Awolowo University, Ile-Ife 220282, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8800-955X","authenticated-orcid":false,"given":"Emmanuel","family":"Mukwevho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Mafikeng Campus, North-West University, Mmabatho 2735, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1038\/srep06768","article-title":"Urinary metabolic profiling of rat models revealed protective function of scoparone against alcohol induced hepatotoxicity","volume":"4","author":"Zhang","year":"2014","journal-title":"Sci. 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