{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:29:37Z","timestamp":1789662577129,"version":"4.0.1"},"reference-count":69,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014189","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry","doi-asserted-by":"publisher","award":["119078-3"],"award-info":[{"award-number":["119078-3"]}],"id":[{"id":"10.13039\/501100014189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Barley sprouts are known to have several effective physiological activities. In this study, the anti-obesity effect of a barley sprout hot water extract (BSE) was confirmed. Saponarin was quantitatively analyzed in BSE using HPLC, and the inhibitory effect on 3T3-L1 pre-adipocyte differentiation into adipocytes was confirmed by Oil Red O staining, TG assay, and Western blotting. In addition, the inhibitory effect of BSE on adipocyte growth was confirmed through glucose uptake and lipolysis of adipocytes. C57\/BL\/6N mice were induced to obesity with a high-fat diet, and BSE was administered to confirm the effect on an animal model. Weight gain, morphological changes in adipose tissue, changes in the food efficiency ratio, and blood biochemical changes were observed, and an improvement effect on fatty liver was confirmed. As a result, the anti-obesity effect of BSE was confirmed in vitro, and it was confirmed that this effect was also effective in vivo and that it could be helpful in the treatment of obesity-related diseases.<\/jats:p>","DOI":"10.3390\/metabo11090610","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T10:12:03Z","timestamp":1631095923000},"page":"610","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Anti-Obesity Effect of Hot Water Extract of Barley Sprout through the Inhibition of Adipocyte Differentiation and Growth"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7335-1993","authenticated-orcid":false,"given":"Myeong-Jin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-068X","authenticated-orcid":false,"given":"Hye-Won","family":"Kawk","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Won","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Teazen Co., Ltd., Haenam 59017, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hee","family":"Jang","sequence":"additional","affiliation":[{"name":"Teazen Co., Ltd., Haenam 59017, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Teazen Co., Ltd., Haenam 59017, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.metabol.2018.09.005","article-title":"The epidemiology of obesity","volume":"92","author":"Chooi","year":"2019","journal-title":"Metabolism"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/jch.12049","article-title":"Obesity-related hypertension: Pathogenesis, cardiovascular risk, and treatment: A position paper of The Obesity Society and the American Society of Hypertension","volume":"15","author":"Landsberg","year":"2013","journal-title":"J. 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