{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T03:00:20Z","timestamp":1770519620863,"version":"3.49.0"},"reference-count":49,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medizinischer Forschungsfonds Tirol","award":["327"],"award-info":[{"award-number":["327"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Patients with Marfan syndrome (MFS) have an increased risk of aortic aneurysm formation, dissection and development of a subtle cardiomyopathy. We analyzed amino acid and lipid metabolic pathways in MFS patients, seeking biomarker patterns as potential monitoring tools of cardiovascular risk with deterioration of myocardial function. We assessed myocardial function in 24 adult MFS patients and compared traditional laboratory values and mass spectrometry-based amino acid, phospholipid and acylcarnitine metabolomes in patients with those in healthy controls. Analytes for which values differed between patients and controls were subjected to regression analysis. A high proportion of patients had signs of impaired diastolic function and elevated serum levels of NT-proBNP. Patients had lower serum levels of taurine, histidine and PCaeC42:3 than controls. The evidence of diastolic dysfunction, aortic root dimensions and history of aortic root surgery correlated with NT-proBNP and taurine levels. Alterations in serum levels of metabolism derived analytes link MFS pathophysiology with inflammation, oxidative stress and incipient cardiomyopathy.<\/jats:p>","DOI":"10.3390\/metabo11120805","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T05:42:10Z","timestamp":1638250930000},"page":"805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Amino Acid and Phospholipid Metabolism as an Indicator of Inflammation and Subtle Cardiomyopathy in Patients with Marfan Syndrome"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-045X","authenticated-orcid":false,"given":"Lisa","family":"Bartenbach","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Health, Division of Pediatrics III\u2014Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Karall","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health, Division of Pediatrics III\u2014Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-125X","authenticated-orcid":false,"given":"Jakob","family":"Koch","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8654-9920","authenticated-orcid":false,"given":"Markus Andreas","family":"Keller","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0963-8268","authenticated-orcid":false,"given":"Herbert","family":"Oberacher","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine and Core Facility Metabolomics, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Scholl-B\u00fcrgi","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health, Division of Pediatrics I\u2014Inherited Metabolic Disorders, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Karall","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health, Division of Pediatrics I\u2014Inherited Metabolic Disorders, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-0955","authenticated-orcid":false,"given":"Gregor","family":"Oemer","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinical Division for Pediatric Cardiology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Meinel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinical Division for Pediatric Cardiology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safwat","family":"Aly","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children, Labatt Family Heart Centre, Division for Pediatric Cardiology, Toronto, ON M5G 1X8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Odri-Komazec","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health, Division of Pediatrics III\u2014Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Geiger","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health, Division of Pediatrics III\u2014Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-3270","authenticated-orcid":false,"given":"Miriam","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health, Division of Pediatrics III\u2014Cardiology, Pulmonology, Allergology and Cystic Fibrosis, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"key":"ref_1","first-page":"220","article-title":"An instance of congenital deformity of all four limbs, more prominent distally, characterised by lengthening of the bones with some increase in gracility","volume":"13","author":"Marfan","year":"1896","journal-title":"Bull. 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