{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:29:35Z","timestamp":1792222175089,"version":"4.4.0"},"reference-count":68,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002737","name":"Regione Siciliana","doi-asserted-by":"publisher","award":["Progetto Obiettivo PSN Anno 2016"],"award-info":[{"award-number":["Progetto Obiettivo PSN Anno 2016"]}],"id":[{"id":"10.13039\/501100002737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Iron deficiency anemia (IDA) is the most frequent hematological disorder in children, with an incidence in industrialized countries of 20.1% between 0 and 4 years of age and 5.9% between 5 and 14 years (39 and 48.1% in developing countries). Although IDA has been recognized for a long time, there are still uncovered issues and room for improving the management of this condition. New frontiers regarding its diagnosis and therapeutic options emerge every day; recently, innovative formulations of iron have been launched, both for oral and parenteral administration, with the aim of offering treatment schedules with higher efficacy and lower toxicity. As a matter of fact, glycinate and liposomal preparations, while maintaining a satisfying efficacy profile, have significantly fewer side effects, in comparison to the traditional elemental iron salts; parenteral iron, usually considered a second-choice therapy reserved to selected cases, may evolve further, as a consequence of the production of molecules with an interesting clinical profile such as ferrocarboxymaltose, which is already available for adolescents aged &gt;14 years. The present article reports the clinically relevant latest insights regarding IDA in children and offers a practical guide to help pediatricians, particularly to choose the most appropriate prevention and therapy strategies.<\/jats:p>","DOI":"10.3390\/metabo12040289","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:29:36Z","timestamp":1648416576000},"page":"289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["New Insights into Iron Deficiency Anemia in Children: A Practical Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Carla","family":"Moscheo","sequence":"first","affiliation":[{"name":"Pediatric Unit, Azienda Ospedaliero Universitaria Policlinico \u201cRodolico-San Marco\u201d, viale Carlo Azeglio Ciampi n.1, 95121 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Licciardello","sequence":"additional","affiliation":[{"name":"Pediatric Onco-Hematology Unit, Azienda Ospedaliero Universitaria Policlinico \u201cRodolico-San Marco\u201d, via Santa Sofia n.78, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Samperi","sequence":"additional","affiliation":[{"name":"Pediatric Onco-Hematology Unit, Azienda Ospedaliero Universitaria Policlinico \u201cRodolico-San Marco\u201d, via Santa Sofia n.78, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"La Spina","sequence":"additional","affiliation":[{"name":"Pediatric Onco-Hematology Unit, Azienda Ospedaliero Universitaria Policlinico \u201cRodolico-San Marco\u201d, via Santa Sofia n.78, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4509-3066","authenticated-orcid":false,"given":"Andrea","family":"Di Cataldo","sequence":"additional","affiliation":[{"name":"Pediatric Onco-Hematology Unit, Azienda Ospedaliero Universitaria Policlinico \u201cRodolico-San Marco\u201d, via Santa Sofia n.78, 95123 Catania, Italy"},{"name":"Department of Clinical and Experimental Medicine, University of Catania, via Santa Sofia 89, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-7473","authenticated-orcid":false,"given":"Giovanna","family":"Russo","sequence":"additional","affiliation":[{"name":"Pediatric Onco-Hematology Unit, Azienda Ospedaliero Universitaria Policlinico \u201cRodolico-San Marco\u201d, via Santa Sofia n.78, 95123 Catania, Italy"},{"name":"Department of Clinical and Experimental Medicine, University of Catania, via Santa Sofia 89, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"ref_1","unstructured":"(2022, February 25). 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