{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:53:57Z","timestamp":1774968837252,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82100950"],"award-info":[{"award-number":["82100950"]}]},{"name":"National Natural Science Foundation of China","award":["81974066"],"award-info":[{"award-number":["81974066"]}]},{"name":"National Natural Science Foundation of China","award":["2019ZB0101"],"award-info":[{"award-number":["2019ZB0101"]}]},{"name":"National Natural Science Foundation of China","award":["shslczdzk05702"],"award-info":[{"award-number":["shslczdzk05702"]}]},{"name":"National Natural 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of Shanghai","doi-asserted-by":"publisher","award":["2019ZB0101"],"award-info":[{"award-number":["2019ZB0101"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["shslczdzk05702"],"award-info":[{"award-number":["shslczdzk05702"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["SHDC2020CR2010A"],"award-info":[{"award-number":["SHDC2020CR2010A"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["22ZR1441100"],"award-info":[{"award-number":["22ZR1441100"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Short bowel syndrome (SBS) is a major cause of intestinal failure (IF) that may require long-term parenteral nutrition (PN) support. However, long-term PN is accompanied by severe complications such as catheter-related blood stream infection (CRBSI) and intestinal failure-associated liver disease (IFALD), and it is associated with high healthcare costs. In this study, we characterized the plasma metabolomic profile and investigated the role of metabolism in predicting long-term PN in pediatric patients with SBS. Untargeted metabolomics was performed in plasma samples from 20 SBS patients with PN support: 6 patients had IFALD and 14 patients had no liver disease. As controls, 18 subjects without liver or intestinal diseases were included for the analysis. SBS patients had distinct plasma metabolomic signatures compared to controls, and several pathways associated with amino acid metabolism and cell death were significantly changed. The presence of IFALD in SBS was associated with alterations of metabolites mainly classified as \u201camino acids, peptides, and analogues\u201d and \u201cbenzene and derivatives\u201d. Serum direct bilirubin levels were negatively correlated with levels of uridine, skatole, and glabrol. Importantly, SBS patients with long-term PN showed significantly increased levels of glutamine compared to those in the short-term PN group. Finally, using multivariate logistic regression analysis, we developed a prediction model including glutamine and creatinine to identify pediatric SBS patients who need long-term PN support. These findings underscore the potential key role of the metabolome in SBS with IF and suggest that metabolomic profiles could be used in long-term PN assessment.<\/jats:p>","DOI":"10.3390\/metabo12070600","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:07:02Z","timestamp":1656374822000},"page":"600","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Untargeted Metabolomics Reveal Parenteral Nutrition-Associated Alterations in Pediatric Patients with Short Bowel Syndrome"],"prefix":"10.3390","volume":"12","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-2339","authenticated-orcid":false,"given":"Bei","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Marine Sciences, Nanjing University of Information Science and Technology, Nanjing 210044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junkai","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China"},{"name":"Shanghai Institute for Pediatric Research, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China"},{"name":"Department of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China"},{"name":"Shanghai Institute for Pediatric Research, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-3614","authenticated-orcid":false,"given":"Lu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China"},{"name":"Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China"},{"name":"Shanghai Institute for Pediatric Research, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/hep.31152","article-title":"New Insights Into Intestinal Failure-Associated Liver Disease in Children","volume":"71","author":"Khalaf","year":"2020","journal-title":"Hepatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clnu.2014.08.017","article-title":"ESPEN endorsed recommendations. 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