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Metabolomics provides an analytical approach to endogenous small molecule metabolites in organisms, summarizes the results of \u201cgene-environment interactions\u201d, and is an ideal analytical tool to obtain \u201cbiomarkers\u201d related to disease information. This study discusses the metabolic changes in neovascular diseases involving the retina and discusses the progress of the study from the perspective of metabolomics design and analysis. This study advocates a comparative strategy based on existing studies, which encompasses optimization of the performance of newly identified biomarkers and the consideration of the basis of existing studies, which facilitates quality control of newly discovered biomarkers and is recommended as an additional reference strategy for new biomarker discovery. Finally, by describing the metabolic mechanisms of retinal and choroidal neovascularization, based on the results of existing studies, this study provides potential opportunities to find new therapeutic approaches.<\/jats:p>","DOI":"10.3390\/metabo12090814","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:13:56Z","timestamp":1661904836000},"page":"814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Metabolomics and Biomarkers in Retinal and Choroidal Vascular Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5067-7966","authenticated-orcid":false,"given":"Xiao-Wen","family":"Hou","sequence":"first","affiliation":[{"name":"School of Public Health, Medical College of Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Medical College of Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Fu","family":"Ke","sequence":"additional","affiliation":[{"name":"School of Public Health, Medical College of Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, EYE & ENT Hospital of Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3362-4613","authenticated-orcid":false,"given":"Chen-Wei","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Public Health, Medical College of Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1046\/j.1432-0436.2001.680406.x","article-title":"Common origins of blood and blood vessels in adults?","volume":"68","author":"Hirschi","year":"2001","journal-title":"Differentiation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mvr.2007.04.011","article-title":"Retinal and choroidal microangiopathies: Therapeutic opportunities","volume":"74","author":"Afzal","year":"2007","journal-title":"Microvasc. 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