{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:34:32Z","timestamp":1773790472774,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013228","name":"Fond de Recherche\u2014Sant\u00e9 Qu\u00e9bec","doi-asserted-by":"publisher","award":["267485"],"award-info":[{"award-number":["267485"]}],"id":[{"id":"10.13039\/100013228","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013228","name":"Fond de Recherche\u2014Sant\u00e9 Qu\u00e9bec","doi-asserted-by":"publisher","award":["000999"],"award-info":[{"award-number":["000999"]}],"id":[{"id":"10.13039\/100013228","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canadian Urology Association Scholarship Fund\u2014Career Development Award","award":["267485"],"award-info":[{"award-number":["267485"]}]},{"name":"Canadian Urology Association Scholarship Fund\u2014Career Development Award","award":["000999"],"award-info":[{"award-number":["000999"]}]},{"name":"Quebec Network for Research on Aging Leverage Funds","award":["267485"],"award-info":[{"award-number":["267485"]}]},{"name":"Quebec Network for Research on Aging Leverage Funds","award":["000999"],"award-info":[{"award-number":["000999"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Women with overactive bladder syndrome (OAB) have a lower urinary ratio of nerve growth factor (NGF) to its precursor (proNGF) compared to healthy controls. MicroRNAs related to NGF and proNGF metabolism and to their receptors may be present in urine and may possess diagnostic value. Urine and blood samples from 20 control and 20 OAB women (50\u201380 years) were obtained, together with validated questionnaires and other clinical parameters. The relative expression of urinary microRNAs was measured with RT-qPCR. MiR-491-5p, which negatively controls the translation of the matrix metalloproteinase-9 (MMP-9), the main enzyme degrading NGF, was significantly decreased in OAB. Similarly, miR-592, which represses p75NTR receptor synthesis, was down-regulated in OAB. Age, renal function and insulin resistance did not affect these results. ROC curves confirmed the high sensitivity of miR-491-5p and miR-592 for diagnosis. On the other hand, miRNAs involved in the expression of proNGF, of survival receptor TrkA and of markers of nerve integrity were similar between groups. The detection of miR-491-5p and miR-592 in urine could be a useful and non-invasive tool for the diagnosis of OAB syndrome in aging women.<\/jats:p>","DOI":"10.3390\/metabo12090820","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T01:50:51Z","timestamp":1661997051000},"page":"820","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Urinary Levels of miR-491-5p and miR-592 as Potential Diagnostic Biomarkers in Female Aging Patients with OAB: A Pilot Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Philippe G.","family":"Cammisotto","sequence":"first","affiliation":[{"name":"Lady Davis Institute, McGill University, Montreal, QC H3T 1E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-113X","authenticated-orcid":false,"given":"Abubakr H.","family":"Mossa","sequence":"additional","affiliation":[{"name":"Lady Davis Institute, McGill University, Montreal, QC H3T 1E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Shamout","sequence":"additional","affiliation":[{"name":"Lady Davis Institute, McGill University, Montreal, QC H3T 1E2, Canada"},{"name":"Division of Urology, Department of Surgery, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lysanne","family":"Campeau","sequence":"additional","affiliation":[{"name":"Lady Davis Institute, McGill University, Montreal, QC H3T 1E2, Canada"},{"name":"Division of Urology, Department of Surgery, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/nau.20798","article-title":"An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction","volume":"29","author":"Haylen","year":"2010","journal-title":"Neurourol. 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