{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:09:31Z","timestamp":1778033371802,"version":"3.51.4"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>The pathophysiology of delayed onset muscle soreness is not entirely known. It seems to be a simple, exercise-induced delayed pain condition, but has remained a mystery for over 120 years. The buildup of lactic acid used to be blamed for muscle fatigue and delayed onset muscle soreness; however, studies in the 1980s largely refuted the role of lactate in delayed onset muscle soreness. Regardless, this belief is widely held even today, not only in the general public, but within the medical and scientific community as well. Current opinion is highlighting lactate\u2019s role in delayed onset muscle soreness, if neural dimension and neuro-energetics are not overlooked. By doing so, lactate seems to have an essential role in the initiation of the primary damage phase of delayed onset muscle soreness within the intrafusal space. Unaccustomed or strenuous eccentric contractions are suggested to facilitate lactate nourishment of proprioceptive sensory neurons in the muscle spindle under hyperexcitation. However, excessive acidosis and lactate could eventually contribute to impaired proprioception and increased nociception under pathological condition. Furthermore, lactate could also contribute to the secondary damage phase of delayed onset muscle soreness in the extrafusal space, primarily by potentiating the role of bradykinin. After all, neural interpretation may help us to dispel a 40-year-old controversy about lactate\u2019s role in the pathophysiology of delayed onset muscle soreness.<\/jats:p>","DOI":"10.3390\/metabo12090857","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T22:37:28Z","timestamp":1663108648000},"page":"857","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Should We Void Lactate in the Pathophysiology of Delayed Onset Muscle Soreness? Not So Fast! Let\u2019s See a Neurocentric View!"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-1306","authenticated-orcid":false,"given":"Bal\u00e1zs","family":"Sonkodi","sequence":"first","affiliation":[{"name":"Department of Health Sciences and Sport Medicine, Hungarian University of Sports Science, 1123 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/00913847.1983.11708485","article-title":"Is Lactic Acid Related to Delayed-Onset Muscle Soreness?","volume":"11","author":"Schwane","year":"1983","journal-title":"Phys. Sportsmed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1249\/00005768-199205000-00004","article-title":"Muscle function after exercise-induced muscle damage and rapid adaptation","volume":"24","author":"Clarkson","year":"1992","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF00635995","article-title":"The consequences of eccentric contractions and their relationship to delayed onset muscle pain","volume":"57","author":"Newham","year":"1988","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12576-015-0397-0","article-title":"Delayed onset muscle soreness: Involvement of neurotrophic factors","volume":"66","author":"Mizumura","year":"2016","journal-title":"J. Physiol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2165\/00007256-200333020-00005","article-title":"Delayed onset muscle soreness: Treatment strategies and performance factors","volume":"33","author":"Cheung","year":"2003","journal-title":"Sports Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sonkodi, B., Berkes, I., and Koltai, E. (2020). Have We Looked in the Wrong Direction for More Than 100 Years? Delayed Onset Muscle Soreness is, in Fact, Neural Microdamage Rather Than Muscle Damage. Antioxidants, 9.","DOI":"10.3390\/antiox9030212"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sonkodi, B., Heged\u0171s, \u00c1., Kopper, B., and Berkes, I. (2022). Significantly Delayed Medium-Latency Response of the Stretch Reflex in Delayed-Onset Muscle Soreness of the Quadriceps Femoris Muscles Is Indicative of Sensory Neuronal Microdamage. J. Funct. Morphol. Kinesiol., 7.","DOI":"10.3390\/jfmk7020043"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"734091","DOI":"10.3389\/fphar.2021.734091","article-title":"Intense Acute Swimming Induces Delayed-Onset Muscle Soreness Dependent on Spinal Cord Neuroinflammation","volume":"12","author":"Borghi","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1249\/00005768-198412000-00002","article-title":"Mechanisms of exercise-induced delayed onset muscular soreness: A brief review","volume":"16","author":"Armstrong","year":"1984","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1123\/jsr.5.3.234","article-title":"Delayed Onset Muscle Soreness: What is It and How Do We Treat It?","volume":"5","author":"Gulick","year":"1996","journal-title":"J. Sport Rehabil."},{"key":"ref_11","first-page":"333","article-title":"Effects of aspirin on delayed muscle soreness","volume":"27","author":"Francis","year":"1987","journal-title":"J. Sports Med. Phys. Fit."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"B177","DOI":"10.1093\/gerona\/55.4.B177","article-title":"Cardiovascular stress associated with concentric and eccentric isokinetic exercise in young and older adults","volume":"55","author":"Overend","year":"2000","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fphys.2019.00536","article-title":"Eccentric Muscle Contractions: Risks and Benefits","volume":"10","author":"Hody","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3917\/sta.054.0063","article-title":"Lactate et exercice: Mythes et r\u00e9alit\u00e9s","volume":"54","author":"Cazorla","year":"2001","journal-title":"Staps"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1152\/japplphysiol.00002.2013","article-title":"Insights into the neural control of eccentric contractions","volume":"116","author":"Duchateau","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1242\/jeb.123158","article-title":"Neural control of lengthening contractions","volume":"219","author":"Duchateau","year":"2016","journal-title":"J. Exp. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF00713506","article-title":"Eccentric and concentric torque-velocity relationships during arm flexion and extension. Influence of strength level","volume":"60","author":"Hortobagyi","year":"1990","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1113\/jphysiol.1952.sp004755","article-title":"The physiological cost of negative work","volume":"117","author":"Abbott","year":"1952","journal-title":"J. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sonkodi, B. (2021). Delayed Onset Muscle Soreness (DOMS): The Repeated Bout Effect and Chemotherapy-Induced Axonopathy May Help Explain the Dying-Back Mechanism in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases. Brain Sci., 11.","DOI":"10.3390\/brainsci11010108"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sonkodi, B., Kopa, Z., and Nyirady, P. (2021). Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?. Cells, 10.","DOI":"10.3390\/cells10081867"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1515\/med-2022-0444","article-title":"Amyotrophic lateral sclerosis and delayed onset muscle soreness in light of the impaired blink and stretch reflexes\u2014Watch out for Piezo2","volume":"17","author":"Sonkodi","year":"2022","journal-title":"Open Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Sonkodi, B. (2022). Delayed Onset Muscle Soreness and Critical Neural Microdamage-Derived Neuroinflammation. Biomolecules, 12.","DOI":"10.3390\/biom12091207"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/nn.4162","article-title":"Piezo2 is the principal mechanotransduction channel for proprioception","volume":"18","author":"Woo","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1152\/japplphysiol.00239.2014","article-title":"Eccentric exercise: Many questions unanswered","volume":"116","author":"Hoppeler","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2519\/jospt.2003.33.10.557","article-title":"Eccentric muscle contractions: Their contribution to injury, prevention, rehabilitation, and sport","volume":"33","author":"LaStayo","year":"2003","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1113\/jphysiol.2007.128827","article-title":"Myofibre damage in human skeletal muscle: Effects of electrical stimulation versus voluntary contraction","volume":"583","author":"Crameri","year":"2007","journal-title":"J. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1152\/physrev.00048.2011","article-title":"The proprioceptive senses: Their roles in signaling body shape, body position and movement, and muscle force","volume":"92","author":"Proske","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1055\/s-0030-1248285","article-title":"Knee proprioception after exercise-induced muscle damage","volume":"31","author":"Torres","year":"2010","journal-title":"Int. J. Sports Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnins.2017.00043","article-title":"Lactate Shuttles in Neuroenergetics-Homeostasis, Allostasis and Beyond","volume":"11","author":"Mason","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/j.1460-9568.2011.07652.x","article-title":"Terminal arbor degeneration--a novel lesion produced by the antineoplastic agent paclitaxel","volume":"33","author":"Bennett","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1152\/jappl.1999.87.6.2007","article-title":"Early events in stretch-induced muscle damage","volume":"87","author":"Morgan","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1023\/A:1019996809849","article-title":"Gate Control Theory Reconsidered","volume":"3","author":"Sufka","year":"2002","journal-title":"Brain Mind"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12017-007-8018-6","article-title":"The sympathetic nervous system and pain","volume":"10","author":"Schlereth","year":"2008","journal-title":"Neuromol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neuropharm.2016.10.012","article-title":"Contribution of large-sized primary sensory neuronal sensitization to mechanical allodynia by upregulation of hyperpolarization-activated cyclic nucleotide gated channels via cyclooxygenase 1 cascade","volume":"113","author":"Sun","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1523\/JNEUROSCI.3803-09.2010","article-title":"Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed-onset muscle soreness)","volume":"30","author":"Murase","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1113\/jphysiol.2012.249235","article-title":"Upregulated glial cell line-derived neurotrophic factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats","volume":"591","author":"Murase","year":"2013","journal-title":"J. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1097\/00002060-200211001-00007","article-title":"Exercise-induced muscle damage in humans","volume":"81","author":"Clarkson","year":"2002","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_38","first-page":"S277","article-title":"Degenerative histological alteration is not required for the induction of muscular mechanical hyperalgesia after lengthening contraction in rats","volume":"65","author":"Hayashi","year":"2015","journal-title":"J. Physiol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0304-3959(03)00257-4","article-title":"Effects of local pressure and vibration on muscle pain from eccentric exercise and hypertonic saline","volume":"105","author":"Weerakkody","year":"2003","journal-title":"Pain"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"eaat9892","DOI":"10.1126\/scitranslmed.aat9892","article-title":"PIEZO2 mediates injury-induced tactile pain in mice and humans","volume":"10","author":"Szczot","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1242\/jeb.02208","article-title":"Neuron-glia metabolic coupling and plasticity","volume":"209","author":"Magistretti","year":"2006","journal-title":"J. Exp. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1469-7580.2002.00064.x","article-title":"Astrocyte-endothelial interactions and blood-brain barrier permeability","volume":"200","author":"Abbott","year":"2002","journal-title":"J. Anat."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"dev174177","DOI":"10.1242\/dev.174177","article-title":"Single cell analysis of adult mouse skeletal muscle stem cells in homeostatic and regenerative conditions","volume":"146","author":"Juan","year":"2019","journal-title":"Development"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1038\/jcbfm.2010.132","article-title":"Comment on recent modeling studies of astrocyte-neuron metabolic interactions","volume":"30","author":"Jolivet","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1007\/s11064-019-02752-1","article-title":"Consequences of a Metabolic Glucose-Depletion on the Survival and the Metabolism of Cultured Rat Astrocytes","volume":"44","author":"Arend","year":"2019","journal-title":"Neurochem. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e09221","DOI":"10.7554\/eLife.09221","article-title":"Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions","volume":"4","author":"Liu","year":"2015","journal-title":"Elife"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13395-015-0065-3","article-title":"Reduced voluntary running performance is associated with impaired coordination as a result of muscle satellite cell depletion in adult mice","volume":"5","author":"Jackson","year":"2015","journal-title":"Skelet. Muscle"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"C1178","DOI":"10.1152\/ajpcell.00090.2020","article-title":"Depletion of resident muscle stem cells negatively impacts running volume, physical function, and muscle fiber hypertrophy in response to lifelong physical activity","volume":"318","author":"Englund","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/cercor\/6.1.50","article-title":"Cellular bases of brain energy metabolism and their relevance to functional brain imaging: Evidence for a prominent role of astrocytes","volume":"6","author":"Magistretti","year":"1996","journal-title":"Cereb. Cortex"},{"key":"ref_50","first-page":"372","article-title":"Effects of vascular occlusion on muscular endurance in dynamic knee extension exercise at different submaximal loads","volume":"20","author":"Wernbom","year":"2006","journal-title":"J. Strength Cond. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/jcbfm.1995.52","article-title":"Acidosis causes failure of astrocyte glutamate uptake during hypoxia","volume":"15","author":"Swanson","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/978-1-4614-4756-6_36","article-title":"Acid-sensing ion channels in pathological conditions","volume":"961","author":"Chu","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11460","DOI":"10.1038\/ncomms11460","article-title":"Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors","volume":"7","author":"Lin","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.pain.2008.01.020","article-title":"Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice","volume":"137","author":"Ikeuchi","year":"2008","journal-title":"Pain"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Sonkodi, B., Varga, E., Hangody, L., Poor, G., and Berkes, I. (2021). Finishing stationary cycling too early after anterior cruciate ligament reconstruction is likely to lead to higher failure. BMC Sports Sci. Med. Rehabil., 13.","DOI":"10.1186\/s13102-021-00377-y"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"146442","DOI":"10.1016\/j.brainres.2019.146442","article-title":"Enhancement of acid-sensing ion channel activity by prostaglandin E2 in rat dorsal root ganglion neurons","volume":"1724","author":"Zhou","year":"2019","journal-title":"Brain Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nn0901-869","article-title":"Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons","volume":"4","author":"Immke","year":"2001","journal-title":"Nat. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"610983","DOI":"10.3389\/fphys.2020.610983","article-title":"Lactate Metabolism and Satellite Cell Fate","volume":"11","author":"Nalbandian","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/bs.irn.2019.06.008","article-title":"Neuroprotective effects of a potent bradykinin B2 receptor antagonist HOE-140 on microvascular permeability, blood flow disturbances, edema formation, cell injury and nitric oxide synthase upregulation following trauma to the spinal cord","volume":"146","author":"Sharma","year":"2019","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_60","first-page":"159","article-title":"A bradykinin BK2 receptor antagonist HOE-140 attenuates blood-spinal cord barrier permeability following a focal trauma to the rat spinal cord. An experimental study using Evans blue, [131]I-sodium and lanthanum tracers","volume":"76","author":"Sharma","year":"2000","journal-title":"Acta Neurochir. Suppl."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"791709","DOI":"10.3389\/fnins.2021.791709","article-title":"The Bradykinin B2 Receptor Agonist (NG291) Causes Rapid Onset of Transient Blood-Brain Barrier Disruption Without Evidence of Early Brain Injury","volume":"15","author":"Erickson","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00421-014-3077-5","article-title":"Changes in electrical pain threshold of fascia and muscle after initial and secondary bouts of elbow flexor eccentric exercise","volume":"115","author":"Lau","year":"2015","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.pain.2013.03.017","article-title":"Nociception originating from the crural fascia in rats","volume":"154","author":"Taguchi","year":"2013","journal-title":"Pain"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.neuroscience.2011.07.066","article-title":"Sensory innervation of the thoracolumbar fascia in rats and humans","volume":"194","author":"Tesarz","year":"2011","journal-title":"Neuroscience"},{"key":"ref_65","first-page":"E92","article-title":"Lactic acid potentiates bradykinin- and low-pH-induced release of CGRP from rat spinal cord slices","volume":"273","author":"Wang","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pain.2008.08.013","article-title":"TRP channels and ASICs mediate mechanical hyperalgesia in models of inflammatory muscle pain and delayed onset muscle soreness","volume":"140","author":"Fujii","year":"2008","journal-title":"Pain"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ota, H., Katanosaka, K., Murase, S., Kashio, M., Tominaga, M., and Mizumura, K. (2013). TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065751"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"644929","DOI":"10.3389\/fphys.2021.644929","article-title":"Piezo2 Knockdown Inhibits Noxious Mechanical Stimulation and NGF-Induced Sensitization in A-Delta Bone Afferent Neurons","volume":"12","author":"Nencini","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1007\/s12031-022-02015-9","article-title":"Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy","volume":"72","author":"Sonkodi","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Bornstein, B., Heinemann-Yerushalmi, L., Krief, S., Adler, R., Dassa, B., Leshkowitz, D., Kim, M., Bewick, G., Banks, R.W., and Zelzer, E. (2022). Molecular characterization of the intact muscle spindle using a multi-omics approach. bioRxiv.","DOI":"10.1101\/2022.07.13.499888"}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/12\/9\/857\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:30:28Z","timestamp":1760142628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/12\/9\/857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":70,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["metabo12090857"],"URL":"https:\/\/doi.org\/10.3390\/metabo12090857","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]}}}