{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:55:25Z","timestamp":1783738525037,"version":"3.55.0"},"reference-count":72,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONACyT","award":["256448\/256454"],"award-info":[{"award-number":["256448\/256454"]}]},{"name":"CONACyT","award":["CONACYT-28941"],"award-info":[{"award-number":["CONACYT-28941"]}]},{"name":"CONACyT","award":["INPRFM-NC17073.0"],"award-info":[{"award-number":["INPRFM-NC17073.0"]}]},{"name":"CONACyT","award":["NC19110.0"],"award-info":[{"award-number":["NC19110.0"]}]},{"name":"Yara Quinto\u2019s fellowship","award":["256448\/256454"],"award-info":[{"award-number":["256448\/256454"]}]},{"name":"Yara Quinto\u2019s fellowship","award":["CONACYT-28941"],"award-info":[{"award-number":["CONACYT-28941"]}]},{"name":"Yara Quinto\u2019s fellowship","award":["INPRFM-NC17073.0"],"award-info":[{"award-number":["INPRFM-NC17073.0"]}]},{"name":"Yara Quinto\u2019s fellowship","award":["NC19110.0"],"award-info":[{"award-number":["NC19110.0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Fibromyalgia (FM) is a pain syndrome characterized by chronic widespread pain and CNS comorbidities. Tilia americana var. mexicana is a medicinal species used to treat anxiety, insomnia, and acute or chronic pain. However, its spectrum of analgesic efficacy for dysfunctional pain is unknown. To investigate a possible therapeutic alternative for FM-type pain, an aqueous Tilia extract (TE) and its flavonoid fraction (FF) containing rutin and isoquercitrin were evaluated alone and\/or combined with clinical drugs (tramadol\u2014TRA and pramipexol\u2014PRA) using the reserpine-induced FM model in rats. Chromatographic analysis allowed the characterization of flavonoids, while a histological analysis confirmed their presence in the brain. TE (10\u2013100 mg\/kg, i.p.) and FF (10\u2013300 mg\/kg, i.p.) produced significant and dose-dependent antihyperalgesic and antiallodynic effects equivalent to TRA (3\u201310 mg\/kg, i.p.) or PRA (0.01\u20131 mg\/kg, s.c.). Nevertheless, the combination of FF + TRA or FF + PRA resulted in an antagonistic interaction by possible competitive action on the serotonin transporter or \u00b5-opioid and D2 receptors, respectively, according to the in silico analysis. Flavonoids were identified in cerebral regions because of their self-epifluorescence. In conclusion, Tilia possesses potential properties to relieve FM-type pain. However, the consumption of this plant or flavonoids such as quercetin derivatives in combination with analgesic drugs might reduce their individual benefits.<\/jats:p>","DOI":"10.3390\/metabo12100916","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T03:30:37Z","timestamp":1664335837000},"page":"916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacological Interaction of Quercetin Derivatives of Tilia americana and Clinical Drugs in Experimental Fibromyalgia"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-6151","authenticated-orcid":false,"given":"Yara Elena","family":"Quinto-Ortiz","sequence":"first","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda de Productos Naturales, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calz. M\u00e9xico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-1508","authenticated-orcid":false,"given":"Mar\u00eda Eva","family":"Gonz\u00e1lez-Trujano","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda de Productos Naturales, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calz. M\u00e9xico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico"},{"name":"Departamento de Farmacia, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, Coyoac\u00e1n, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5560-2645","authenticated-orcid":false,"given":"Edith","family":"S\u00e1nchez-Jaramillo","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda Molecular, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calz. M\u00e9xico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1968-8813","authenticated-orcid":false,"given":"Gabriel Fernando","family":"Moreno-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda de Productos Naturales, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calz. M\u00e9xico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00f3n","family":"Jacinto-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda de Productos Naturales, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calz. M\u00e9xico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Pellicer","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda de Productos Naturales, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calz. M\u00e9xico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alonso","family":"Fern\u00e1ndez-Guasti","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda Conductual, Departamento de Farmacobiolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados (CINVESTAV) Sede Sur, Calz. de los Tenorios 235, Col. Granjas Coapa, Tlalpan, Mexico City 14330, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6864-6735","authenticated-orcid":false,"given":"Alberto","family":"Hernandez-Leon","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda de Productos Naturales, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Calz. M\u00e9xico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico"},{"name":"Departamento de Farmacia, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, Coyoac\u00e1n, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","first-page":"1065","article-title":"Fibromyalgia: One year in review 2022","volume":"40","author":"Giorgi","year":"2022","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5001\/omj.2012.44","article-title":"Fibromyalgia syndrome: An overview of pathophysiology, diagnosis and management","volume":"27","author":"Jahan","year":"2012","journal-title":"Oman Med. 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