{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:33:02Z","timestamp":1792513982694,"version":"4.5.0"},"reference-count":70,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20AIREA35080151"],"award-info":[{"award-number":["20AIREA35080151"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Although exercise training is an important recommendation for the management of type 1 diabetes (T1D), most of the available research studies predominantly focus on male subjects. Given the importance of sex as a biological variable, additional studies are required to improve the knowledge gap regarding sex differences in T1D research. Therefore, the purpose of this study was to examine the role of exercise training in mediating changes in glucose homeostasis and skeletal muscle metabolism in T1D female mice. Female mice were injected with streptozotocin (STZ) to induce T1D. Two weeks after STZ injection, control (CON) and STZ mice were exercise trained on a treadmill for 4 weeks. Aerobic exercise training failed to improve glucose tolerance, prevent the decrease in body weight and adipose tissue mass, or attenuate muscle atrophy in T1D female mice. However, insulin sensitivity was improved in T1D female mice after exercise training. Aerobic exercise training maintained skeletal muscle triglyceride content but did not prevent depletion of skeletal muscle or liver glycogen in T1D mice. Gene expression analysis suggested that T1D resulted in decreased glucose transport, decreased ketone body oxidation, and increased fatty acid metabolism in the skeletal muscle, which was not altered by exercise training. These data demonstrate that 4 weeks of aerobic exercise training of a moderate intensity is insufficient to counteract the negative effects of T1D in female mice, but does lead to an improvement in insulin sensitivity.<\/jats:p>","DOI":"10.3390\/metabo12100948","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T04:00:02Z","timestamp":1665288002000},"page":"948","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Effects of Exercise Training on Glucose Homeostasis and Muscle Metabolism in Type 1 Diabetic Female Mice"],"prefix":"10.3390","volume":"12","author":[{"given":"Caitlin C.","family":"O\u2019Neill","sequence":"first","affiliation":[{"name":"Heart and Muscle Metabolism Laboratory, Health and Exercise Physiology Department, Ursinus College, Collegeville, PA 19426, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica J.","family":"Locke","sequence":"additional","affiliation":[{"name":"Heart and Muscle Metabolism Laboratory, Health and Exercise Physiology Department, Ursinus College, Collegeville, PA 19426, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren A.","family":"Sipf","sequence":"additional","affiliation":[{"name":"Heart and Muscle Metabolism Laboratory, Health and Exercise Physiology Department, Ursinus College, Collegeville, PA 19426, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3552-9476","authenticated-orcid":false,"given":"Jack H.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Heart and Muscle Metabolism Laboratory, Health and Exercise Physiology Department, Ursinus College, Collegeville, PA 19426, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin K.","family":"Drebushenko","sequence":"additional","affiliation":[{"name":"Heart and Muscle Metabolism Laboratory, Health and Exercise Physiology Department, Ursinus College, Collegeville, PA 19426, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan S.","family":"Berger","sequence":"additional","affiliation":[{"name":"Heart and Muscle Metabolism Laboratory, Health and Exercise Physiology Department, Ursinus College, Collegeville, PA 19426, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke S.","family":"Segich","sequence":"additional","affiliation":[{"name":"Heart and Muscle Metabolism Laboratory, Health and Exercise Physiology Department, Ursinus College, Collegeville, PA 19426, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-9556","authenticated-orcid":false,"suffix":"Jr.","given":"Stephen C.","family":"Kolwicz","sequence":"additional","affiliation":[{"name":"Heart and Muscle Metabolism Laboratory, Health and Exercise Physiology Department, Ursinus College, Collegeville, PA 19426, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2017). Classification and Diagnosis of Diabetes. Diabetes Care, 40, S11\u2013S24.","DOI":"10.2337\/dc17-S005"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S2213-8587(14)70248-7","article-title":"Risk of All-Cause Mortality and Vascular Events in Women Versus Men with Type 1 Diabetes: A Systematic Review and Meta-Analysis","volume":"3","author":"Huxley","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Manicardi, V., Russo, G., Napoli, A., Torlone, E., Volsi, P.L., Giorda, C.B., Musacchio, N., Nicolucci, A., Suraci, C., and Lucisano, G. (2016). Gender-Disparities in Adults with Type 1 Diabetes: More Than a Quality of Care Issue. A Cross-Sectional Observational Study from the Amd Annals Initiative. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162960"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jdiacomp.2018.01.002","article-title":"Sex-Specific Differences in Insulin Resistance in Type 1 Diabetes: The Cacti Cohort","volume":"32","author":"Millstein","year":"2018","journal-title":"J. Diabetes Complicat."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"E44","DOI":"10.1152\/ajpendo.00411.2019","article-title":"Sexual Dimorphism in Human Skeletal Muscle Mitochondrial Bioenergetics in Response to Type 1 Diabetes","volume":"318","author":"Monaco","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1007\/s00125-021-05540-1","article-title":"Normal to Enhanced Intrinsic Mitochondrial Respiration in Skeletal Muscle of Middle- to Older-Aged Women and Men with Uncomplicated Type 1 Diabetes","volume":"64","author":"Monaco","year":"2021","journal-title":"Diabetologia"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1080\/17461391.2014.911354","article-title":"Where Are All the Female Participants in Sports and Exercise Medicine Research?","volume":"14","author":"Costello","year":"2014","journal-title":"Eur. J. Sport. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neubiorev.2010.07.002","article-title":"Sex Bias in Neuroscience and Biomedical Research","volume":"35","author":"Beery","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/cphy.c150016","article-title":"Glucose Transporters in Cardiac Metabolism and Hypertrophy","volume":"6","author":"Shao","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/78693","article-title":"Targeted Disruption of the Glucose Transporter 4 Selectively in Muscle Causes Insulin Resistance and Glucose Intolerance","volume":"6","author":"Zisman","year":"2000","journal-title":"Nat. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrm782","article-title":"Regulated Transport of the Glucose Transporter Glut4","volume":"3","author":"Bryant","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.2337\/diabetes.48.8.1667","article-title":"5\u2032 Amp-Activated Protein Kinase Activation Causes Glut4 Translocation in Skeletal Muscle","volume":"48","author":"Hirshman","year":"1999","journal-title":"Diabetes"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1152\/physrev.00038.2012","article-title":"Exercise, Glut4, and Skeletal Muscle Glucose Uptake","volume":"93","author":"Richter","year":"2013","journal-title":"Physiol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0140-6736(91)90988-2","article-title":"Epidemiological Evidence for \u201cDouble Diabetes\u201d","volume":"337","author":"Teupe","year":"1991","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1007\/s00125-013-2904-2","article-title":"Insulin Resistance in Type 1 Diabetes: What Is \u2018Double Diabetes\u2019 and What Are the Risks?","volume":"56","author":"Cleland","year":"2013","journal-title":"Diabetologia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.beem.2014.01.005","article-title":"Impact of Diet and Exercise on Lipid Management in the Modern Era","volume":"28","author":"Franklin","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.2337\/dc16-1728","article-title":"Physical Activity\/Exercise and Diabetes: A Position Statement of the American Diabetes Association","volume":"39","author":"Colberg","year":"2016","journal-title":"Diabetes Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.diabres.2017.11.036","article-title":"Clinical Outcomes to Exercise Training in Type 1 Diabetes: A Systematic Review and Meta-Analysis","volume":"139","author":"Ostman","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/jcb.25658","article-title":"Prior Exercise Training Prevent Hyperglycemia in Stz Mice by Increasing Hepatic Glycogen and Mitochondrial Function on Skeletal Muscle","volume":"118","author":"Serafini","year":"2017","journal-title":"J. Cell Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jcjd.2017.09.013","article-title":"Effect of Combined Exercise Versus Aerobic-Only Training on Skeletal Muscle Lipid Metabolism in a Rodent Model of Type 1 Diabetes","volume":"42","author":"Dotzert","year":"2018","journal-title":"Can. J. Diabetes"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"26379","DOI":"10.1038\/srep26379","article-title":"Metabolomic Response of Skeletal Muscle to Aerobic Exercise Training in Insulin Resistant Type 1 Diabetic Rats","volume":"6","author":"Dotzert","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.metabol.2013.05.012","article-title":"The Role of Resistance and Aerobic Exercise Training on Insulin Sensitivity Measures in Stz-Induced Type 1 Diabetic Rodents","volume":"62","author":"Hall","year":"2013","journal-title":"Metabolism"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"481427","DOI":"10.1155\/2011\/481427","article-title":"Exercise Increases Insulin Content and Basal Secretion in Pancreatic Islets in Type 1 Diabetic Mice","volume":"2011","author":"Huang","year":"2011","journal-title":"Exp. Diabetes Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bbrc.2018.05.009","article-title":"Aerobic Exercise Training Decreases Cereblon and Increases Ampk Signaling in the Skeletal Muscle of Stz-Induced Diabetic Rats","volume":"501","author":"Ko","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s41073-019-0068-4","article-title":"Measuring the Data Gap: Inclusion of Sex and Gender Reporting in Diabetes Research","volume":"4","author":"Day","year":"2019","journal-title":"Res. Integr. Peer Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3389\/fendo.2018.00674","article-title":"Could Age, Sex and Physical Fitness Affect Blood Glucose Responses to Exercise in Type 1 Diabetes?","volume":"9","author":"Yardley","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"H2768-76","DOI":"10.1152\/ajpheart.00292.2004","article-title":"Sex Modifies Exercise and Cardiac Adaptation in Mice","volume":"287","author":"Konhilas","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e15174","DOI":"10.14814\/phy2.15174","article-title":"Sex Differences in Endurance Exercise Capacity and Skeletal Muscle Lipid Metabolism in Mice","volume":"10","author":"Holcomb","year":"2022","journal-title":"Physiol. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Saadane, A., Lessieur, E.M., Du, Y., Liu, H., and Kern, T.S. (2020). Successful Induction of Diabetes in Mice Demonstrates No Gender Difference in Development of Early Diabetic Retinopathy. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0238727"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1113\/jphysiol.2005.095729","article-title":"Cardioprotection Afforded by Chronic Exercise Is Mediated by the Sarcolemmal, and Not the Mitochondrial, Isoform of the Katp Channel in the Rat","volume":"569","author":"Brown","year":"2005","journal-title":"J. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmet.2018.05.008","article-title":"Sex Differences in Lipid and Lipoprotein Metabolism","volume":"15","author":"Palmisano","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00125-019-05040-3","article-title":"Sex Differences in Metabolic Regulation and Diabetes Susceptibility","volume":"63","author":"Tramunt","year":"2020","journal-title":"Diabetologia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/dmr.5610030308","article-title":"Mouse Models of Insulin Dependent Diabetes: Low-Dose Streptozocin-Induced Diabetes and Nonobese Diabetic (Nod) Mice","volume":"3","author":"Kolb","year":"1987","journal-title":"Diabetes Metab. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1073\/pnas.0602956103","article-title":"Estrogens Protect Pancreatic Beta-Cells from Apoptosis and Prevent Insulin-Deficient Diabetes Mellitus in Mice","volume":"103","author":"Chu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cmet.2006.04.003","article-title":"Loss of Class Ia Pi3k Signaling in Muscle Leads to Impaired Muscle Growth, Insulin Response, and Hyperlipidemia","volume":"3","author":"Luo","year":"2006","journal-title":"Cell Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1172\/JCI86522","article-title":"Insulin and Igf-1 Receptors Regulate Foxo-Mediated Signaling in Muscle Proteostasis","volume":"126","author":"Lee","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2337\/dc09-0264","article-title":"Excessive Loss of Skeletal Muscle Mass in Older Adults with Type 2 Diabetes","volume":"32","author":"Park","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2337\/dc06-2537","article-title":"Accelerated Loss of Skeletal Muscle Strength in Older Adults with Type 2 Diabetes: The Health, Aging, and Body Composition Study","volume":"30","author":"Park","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ncb0203-87","article-title":"Signalling Pathways That Mediate Skeletal Muscle Hypertrophy and Atrophy","volume":"5","author":"Glass","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.biochem.75.103004.142622","article-title":"Signaling Pathways in Skeletal Muscle Remodeling","volume":"75","author":"Olson","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/laban0209-55","article-title":"Insights into Modeling Streptozotocin-Induced Diabetes in Icr Mice","volume":"38","author":"Dekel","year":"2009","journal-title":"Lab. Anim."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1210\/endo.135.6.7988458","article-title":"Gender Differences in the Metabolic Response to Graded Numbers of Transplanted Islets of Langerhans","volume":"135","author":"Bell","year":"1994","journal-title":"Endocrinology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0031-9384(96)00222-3","article-title":"Diabetes Reduces Growth and Body Composition More in Male Than in Female Rats","volume":"60","author":"Cortright","year":"1996","journal-title":"Physiol. Behav."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Harvey, K.L., Holcomb, L.E., and Kolwicz, S.C. (2019). Ketogenic Diets and Exercise Performance. Nutrients, 11.","DOI":"10.3390\/nu11102296"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1210\/jcem.86.3.7304","article-title":"Clinical Review 124: Diabetic Dyslipidemia: Causes and Consequences","volume":"86","author":"Goldberg","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1161\/CIRCULATIONAHA.109.192521","article-title":"Exercise Training for Type 2 Diabetes Mellitus: Impact on Cardiovascular Risk: A Scientific Statement from the American Heart Association","volume":"119","author":"Marwick","year":"2009","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tem.2020.01.015","article-title":"Dyslipidemia in Type 1 Diabetes: Amaskeddanger","volume":"31","author":"Verges","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_48","first-page":"972","article-title":"Mouse Bone Marrow Stromal Cell Line Mc3t3-G2\/Pa6 with Hematopoietic-Supporting Activity Expresses High Levels of Stem Cell Antigen Sca-1","volume":"25","author":"Satoh","year":"1997","journal-title":"Exp. Hematol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"7085","DOI":"10.1074\/jbc.272.11.7085","article-title":"Insulin-Induced Recruitment of Glucose Transporter 4 (Glut4) and Glut1 in Isolated Rat Cardiac Myocytes. Evidence of the Existence of Different Intracellular Glut4 Vesicle Populations","volume":"272","author":"Fischer","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.1016\/S0021-9258(18)83106-4","article-title":"Cloning and Characterization of the Major Insulin-Responsive Glucose Transporter Expressed in Human Skeletal Muscle and Other Insulin-Responsive Tissues","volume":"264","author":"Fukumoto","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0925-4439(94)90007-8","article-title":"In Vivo Glucose Uptake and Glucose Transporter Proteins Glut1 and Glut4 in Heart and Various Types of Skeletal Muscle from Streptozotocin-Diabetic Rats","volume":"1225","author":"Kainulainen","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4137\/BMI.S38440","article-title":"Significance of Hba1c Test in Diagnosis and Prognosis of Diabetic Patients","volume":"11","author":"Sherwani","year":"2016","journal-title":"Biomark. Insights"},{"key":"ref_53","first-page":"196","article-title":"Determination of Rbc Survival in C57bl\/6 and C57bl\/6-Tg(Ubc-Gfp) Mice","volume":"65","author":"Dholakia","year":"2015","journal-title":"Comp. Med."},{"key":"ref_54","first-page":"E10187","article-title":"Chronic Social Stress-Induced Hyperglycemia in Mice Couples Individual Stress Susceptibility to Impaired Spatial Memory","volume":"115","author":"Jene","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3389\/fphys.2017.00974","article-title":"Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains","volume":"8","author":"Avila","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3389\/fphys.2016.00636","article-title":"Fvb\/Nj Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise","volume":"7","author":"Gibb","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"R1006","DOI":"10.1152\/ajpregu.00476.2004","article-title":"Strain-Dependent Differences in Responses to Exercise Training in Inbred and Hybrid Mice","volume":"288","author":"Massett","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1152\/japplphysiol.00991.2004","article-title":"Inter-and Intrastrain Variation in Mouse Critical Running Speed","volume":"98","author":"Billat","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1152\/japplphysiol.00706.2007","article-title":"Short-Term Treadmill Running in the Rat: What Kind of Stressor Is It?","volume":"103","author":"Brown","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"10587","DOI":"10.1073\/pnas.142301999","article-title":"Coordinated Patterns of Gene Expression for Substrate and Energy Metabolism in Skeletal Muscle of Diabetic Mice","volume":"99","author":"Yechoor","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e013039","DOI":"10.1161\/JAHA.119.013039","article-title":"Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization","volume":"9","author":"Brahma","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1096\/fj.201500128","article-title":"Skeletal Muscle Pgc-1alpha Modulates Systemic Ketone Body Homeostasis and Ameliorates Diabetic Hyperketonemia in Mice","volume":"30","author":"Svensson","year":"2016","journal-title":"FASEB J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1152\/japplphysiol.00598.2010","article-title":"Endurance Training-Induced Accumulation of Muscle Triglycerides Is Coupled to Upregulation of Stearoyl-Coa Desaturase 1","volume":"109","author":"Dobrzyn","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s13300-017-0333-9","article-title":"A Review of Insulin Resistance in Type 1 Diabetes: Is There a Place for Adjunctive Metformin?","volume":"9","author":"Priya","year":"2018","journal-title":"Diabetes Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.metabol.2015.09.002","article-title":"Insulin Resistance in Type 1 Diabetes Mellitus","volume":"64","author":"Kaul","year":"2015","journal-title":"Metabolism"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/XCE.0000000000000239","article-title":"The Acute Vs. Chronic Effect of Exercise on Insulin Sensitivity: Nothing Lasts Forever","volume":"10","author":"DiMenna","year":"2021","journal-title":"Cardiovasc. Endocrinol. Metab."},{"key":"ref_67","first-page":"1393","article-title":"Exercise Training and Glucose Uptake by Skeletal Muscle in Rats","volume":"55","author":"Ivy","year":"1983","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s13300-019-00743-7","article-title":"Insulin Therapy in Adults with Type 1 Diabetes Mellitus: A Narrative Review","volume":"11","author":"Janez","year":"2020","journal-title":"Diabetes Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1055\/s-2004-830528","article-title":"Moderate Exercise with a Dietary Vitamin C and E Combination Protects against Streptozotocin-Induced Oxidative Damage to the Kidney and Lens in Pregnant Rats","volume":"113","author":"Simsek","year":"2005","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_70","first-page":"5","article-title":"Streptozotocin-Induced Diabetic Models in Mice and Rats","volume":"70","author":"Wu","year":"2008","journal-title":"Curr. Protoc. Pharmacol."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/12\/10\/948\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:47:01Z","timestamp":1760143621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/12\/10\/948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,5]]},"references-count":70,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["metabo12100948"],"URL":"https:\/\/doi.org\/10.3390\/metabo12100948","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,5]]}}}