{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:10:54Z","timestamp":1776820254105,"version":"3.51.2"},"reference-count":60,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Project of Suzhou Nursing Society","award":["SZHL-B-202207"],"award-info":[{"award-number":["SZHL-B-202207"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Metabolic abnormalities as side effects of androgen-deprivation therapy (ADT) can accelerate progression of prostate cancer (PCa) and increase risks of cardiovascular diseases. A healthy dietary pattern (DP) plays an important role in regulating glycolipid metabolism, while evidence about DP on ADT-related metabolic abnormalities is still controversial. To explore the effect of DP on metabolic outcomes in PCa patients with ADT, PubMed, Embase, Cochrane, and CINAHL were searched from inception to 10 September 2022. Risk of biases was evaluated through Cochrane Collaboration\u2019s Tool. If heterogeneity was low, the fixed-effects model was carried out; otherwise, the random-effects model was used. Data were determined by calculating mean difference (MD) or standardized MD (SMD) with 95% confidence intervals (CIs). Nine studies involving 421 patients were included. The results showed that healthy DP significantly improved glycated hemoglobin (MD: \u22120.13; 95% CI: \u22120.24, \u22120.02; p = 0.020), body mass index (MD: \u22121.02; 95% CI: \u22121.29, \u22120.75; p &lt; 0.001), body fat mass (MD: \u22121.78; 95% CI: \u22122.58, \u22120.97; p &lt; 0.001), triglyceride (MD: \u22120.28; 95% CI: \u22120.51, \u22120.04; p = 0.020), systolic blood pressure (MD: \u22126.30; 95% CI: \u221211.15, \u22121.44; p = 0.010), and diastolic blood pressure (MD: \u22122.94; 95% CI: \u22125.63, \u22120.25; p = 0.030), although its beneficial effects on other glycolipid metabolic indicators were not found. Additionally, a healthy DP also lowered the level of PSA (MD: \u22121.79; 95% CI: \u22122.25, \u22121.33; p &lt; 0.001). The meta-analysis demonstrated that a healthy DP could improve ADT-related metabolic abnormalities and be worthy of being recommended for PCa patients with ADT.<\/jats:p>","DOI":"10.3390\/metabo12100969","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T22:21:11Z","timestamp":1665699671000},"page":"969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Beneficial Effect of a Healthy Dietary Pattern on Androgen Deprivation Therapy-Related Metabolic Abnormalities in Patients with Prostate Cancer: A Meta-Analysis Based on Randomized Controlled Trials and Systematic Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Lili","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunya","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Nursing, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Nursing, Medical College, Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Wang","sequence":"additional","affiliation":[{"name":"The Division of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"6","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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