{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:12:32Z","timestamp":1792289552527,"version":"4.4.0"},"reference-count":120,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Nerve cell death accounts for various neurodegenerative disorders, in which altered immunity to the integrated central nervous system (CNS) might have destructive consequences. This undesirable immune response often affects the progressive neurodegenerative diseases such as Alzheimer\u2019s disease, Parkinson\u2019s disease, schizophrenia and\/or amyotrophic lateral sclerosis (ALS). It has been shown that commensal gut microbiota could influence the brain and\/or several machineries of immune function. In other words, neurodegenerative disorders may be connected to the gut\u2013brain\u2013immune correlational system. The engrams in the brain could retain the information of a certain inflammation in the body which might be involved in the pathogenesis of neurodegenerative disorders. Tactics involving the use of probiotics and\/or fecal microbiota transplantation (FMT) are now evolving as the most promising and\/or valuable for the modification of the gut\u2013brain\u2013immune axis. More deliberation of this concept and the roles of gut microbiota would lead to the development of stupendous treatments for the prevention of, and\/or therapeutics for, various intractable diseases including several neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/metabo12111052","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T03:36:44Z","timestamp":1667360204000},"page":"1052","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A New Concept of Associations between Gut Microbiota, Immunity and Central Nervous System for the Innovative Treatment of Neurodegenerative Disorders"],"prefix":"10.3390","volume":"12","author":[{"given":"Sayuri","family":"Yoshikawa","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition, Nara Women\u2019s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurumi","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Nara Women\u2019s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Nara Women\u2019s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Nara Women\u2019s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Nara Women\u2019s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-5345","authenticated-orcid":false,"given":"Satoru","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Nara Women\u2019s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41583-018-0055-7","article-title":"Inflammasome signalling in brain function and neurodegenerative disease","volume":"19","author":"Heneka","year":"2018","journal-title":"Nat. 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