{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:59:00Z","timestamp":1790632740753,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science, Technology and Innovation Commission of Shenzhen","award":["JCYJ20210324113610029"],"award-info":[{"award-number":["JCYJ20210324113610029"]}]},{"name":"Science, Technology and Innovation Commission of Shenzhen","award":["SZSM 201812090"],"award-info":[{"award-number":["SZSM 201812090"]}]},{"name":"Science, Technology and Innovation Commission of Shenzhen","award":["2020YFE0202200"],"award-info":[{"award-number":["2020YFE0202200"]}]},{"name":"Sanming Project of Medicine in Shenzhen","award":["JCYJ20210324113610029"],"award-info":[{"award-number":["JCYJ20210324113610029"]}]},{"name":"Sanming Project of Medicine in Shenzhen","award":["SZSM 201812090"],"award-info":[{"award-number":["SZSM 201812090"]}]},{"name":"Sanming Project of Medicine in Shenzhen","award":["2020YFE0202200"],"award-info":[{"award-number":["2020YFE0202200"]}]},{"name":"China State Key Basic Research Program Grants","award":["JCYJ20210324113610029"],"award-info":[{"award-number":["JCYJ20210324113610029"]}]},{"name":"China State Key Basic Research Program Grants","award":["SZSM 201812090"],"award-info":[{"award-number":["SZSM 201812090"]}]},{"name":"China State Key Basic Research Program Grants","award":["2020YFE0202200"],"award-info":[{"award-number":["2020YFE0202200"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>The quantitative level of steroid hormones (SHs) in some body fluids have been accepted for clinical diagnosis, whereas their distribution in aqueous humor (AH) is unknown yet. Herein, a profiling study was conducted with a total of 171 AH and 107 plasma samples using liquid chromatography coupled with tandem mass spectrometry (LC MS\/MS). For the first time, six kinds of SHs in AH were quantitatively estimated, and their abundances were ranked at cortisol (F), corticosterone (COR), androstenedione (A2), and 11-deoxycortisol (11DOC). The corresponding abundance of all SHs in AH was significantly lower than those in plasma, while there was a lack of a proportional relationship with the abundance of plasma SHs. Dehydroepiandrosterone sulfate, the most abundant plasma SH, was undetectable in AH, implying that the blood\u2013aqueous barrier might specifically block its transferral. Axial myopia generally results from many factors throughout the entire eye from tissues and molecules; furthermore, the correlation of AH SHs and axial myopia was assessed to look for their indication in such myopia. The panel with five kinds of AH SHs (F, COR, CORT, ALD and A2) was functional as a discriminator for axial myopia and control. The abundance of SHs, therefore, has a specific distribution in AH and can potentially contribute to axial myopia.<\/jats:p>","DOI":"10.3390\/metabo12121220","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T04:10:02Z","timestamp":1670213402000},"page":"1220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0255-9054","authenticated-orcid":false,"given":"Tiansheng","family":"Chou","sequence":"first","affiliation":[{"name":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Department of Proteomics, Beijing Genomics Institute (BGI), Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Proteomics, Beijing Genomics Institute (BGI), Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonghui","family":"Yan","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyi","family":"Mei","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangnan","family":"Sun","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqun","family":"Xi","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Institute, Shenzhen Eye Hospital, Jinan University, Shenzhen 518040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zi","sequence":"additional","affiliation":[{"name":"Department of Proteomics, Beijing Genomics Institute (BGI), Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Department of Proteomics, Beijing Genomics Institute (BGI), Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11154-007-9052-2","article-title":"Basic concepts and recent developments in human steroid hormone biosynthesis","volume":"8","author":"Ghayee","year":"2007","journal-title":"Rev. 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