{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:38:47Z","timestamp":1762079927681,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:00:00Z","timestamp":1670716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Support Fund for Teaching, Research and Extension (FAEPEX) of the University of Campinas","award":["CNPq (303068\/2021-3)."],"award-info":[{"award-number":["CNPq (303068\/2021-3)."]}]},{"name":"National Council for Scientific and Technological Development (CNPq)","award":["CNPq (303068\/2021-3)."],"award-info":[{"award-number":["CNPq (303068\/2021-3)."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>The results of the studies on the pattern of insulin sensitivity (IS) are contradictory in patients with GH deficiency (GHD); however, the interference of the GHD onset stage, childhood or adulthood in the IS has not been assessed by euglycemic hyperinsulinemic clamp (EHC), a gold-standard method for the assessment of insulin sensitivity. In a prospective cross-sectional study, we assessed IS and body composition in 17 adults with hypopituitarism without GH replacement, ten with childhood-onset (COGHD) and seven with adulthood-onset (AOGHD) and compared them to paired control groups. COGHD presented higher IS (p = 0.0395) and a similar percentage of fat mass (PFM) to AOGHD. COGHD showed higher IS than the control group (0.0235), despite a higher PFM (0.0022). No differences were found between AODGH and the control group. In AOGHD and the control group, IS was negatively correlated with PFM (rs: \u22120.8214, p = 0.0234 and rs: \u22120.3639, p &lt; 0.0344), while this correlation was not observed with COGHD (rs: \u22120.1152, p = 0.7514). Despite the higher PFM, patients with COGHD were more sensitive to insulin than paired healthy individuals, while patients with AOGHD showed similar IS compared to controls. The lack of GH early in life could modify the metabolic characteristics of tissues related to the glucose metabolism, inducing beneficial effects on IS that persist into adulthood. Thus, the glycometabolic findings in patients with COGHD seems to be not applicable to AOGHD.<\/jats:p>","DOI":"10.3390\/metabo12121251","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T01:42:27Z","timestamp":1670809347000},"page":"1251","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Childhood-Onset GH Deficiency versus Adult-Onset GH Deficiency: Relevant Differences Regarding Insulin Sensitivity"],"prefix":"10.3390","volume":"12","author":[{"given":"Heraldo Mendes","family":"Garmes","sequence":"first","affiliation":[{"name":"Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-852, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro Rosell","family":"Castillo","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-852, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Monte Alegre","sequence":"additional","affiliation":[{"name":"Internal Medicine Division, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-852, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aglecio Luiz","family":"de Souza","sequence":"additional","affiliation":[{"name":"Internal Medicine Division, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-852, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeelen Ballesteros","family":"Atala","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-852, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-5701","authenticated-orcid":false,"given":"Denise Engelbrecht","family":"Zantut-Wittmann","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-852, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1056\/NEJMra1817346","article-title":"Pathogenesis and Diagnosis of Growth Hormone Deficiency in Adults","volume":"380","author":"Melmed","year":"2019","journal-title":"N. 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