{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:26:52Z","timestamp":1787506012880,"version":"build-2736575974"},"reference-count":15,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Psoriasis is a skin disease with occasional involvement of non-cutaneous territories. Beyond the usual, cardiovascular events are more frequent in these patients and correlate only partially with disease activity, suggesting the presence of other unknown factors. We selected ten psoriatic patients without treatment in the last year and matched them for age and gender with eleven healthy subjects. Ficoll-extracted mononuclear cells were analyzed with flow cytometry for monocyte surface phenotype markers, intracellular NF\u03baB\/inflammasome-dependent interleukins, and chemotaxis receptor CXCR3. Using ELISA, patient serum was evaluated for ADAMTS7 and CXCL10. Inflammatory M1 monocytes showed higher levels of IL-1\u03b2 and IL-6 in psoriatic patients. M2 monocytes also showed higher levels of intracellular inflammatory cytokines. Nevertheless, IL-6 values were higher compared to other monocytes and IL-1\u03b2. The mTORC activation markers ADAMTS7 and S6Rp were higher in psoriatic patients than in healthy controls. In psoriatic patients, serum levels of ADAMTS7 were elevated, and M2 monocytes showed a distinct inflammatory response with higher relative levels of NF\u03baB-dependent IL-6 and less activity of the CXCR3\u2013CXCL10 chemotactic pathway. These data suggest pathways with potential markers for prediction and early detection of cardiovascular risk in psoriatic patients.<\/jats:p>","DOI":"10.3390\/metabo13010116","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T01:32:26Z","timestamp":1673487146000},"page":"116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New Markers for Cardiovascular Disease in Psoriatic Patients: Preliminary Study on Monocyte Phenotype, ADAMTS7, and mTOR Activity"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-5443","authenticated-orcid":false,"given":"Khanty","family":"Loyola","sequence":"first","affiliation":[{"name":"Dermatology Section, Surgery Department, Facultad de Medicina Cl\u00ednica Alemana de Santiago, Universidad del Desarrollo, Santiago P.O. Box 7630000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8819-8546","authenticated-orcid":false,"given":"Claudio","family":"Karsulovic","sequence":"additional","affiliation":[{"name":"Rheumatology Section, Internal Medicine Department, Facultad de Medicina Cl\u00ednica Alemana de Santiago, Universidad del Desarrollo, Santiago P.O. Box 7630000, Chile"},{"name":"Investigation in Dermatology and Autoimmunity\u2014IDeA Lab, Instituto de Ciencias e Innovaci\u00f3n en Medicina, Universidad del Desarrollo, Santiago P.O. Box 7630000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Dermatology Section, Surgery Department, Facultad de Medicina Cl\u00ednica Alemana de Santiago, Universidad del Desarrollo, Santiago P.O. Box 7630000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-6596","authenticated-orcid":false,"given":"Claudio","family":"Perez","sequence":"additional","affiliation":[{"name":"Cancer Immunology and Regulation Laboratory, Immunology Disciplinary Program, Facultad de Medicina, Universidad de Chile, Santiago PO Box 8380000, Chile"},{"name":"Cell Therapy Laboratory, Hospital Cl\u00ednico de la Universidad de Chile, Santiago P.O. Box 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-4156","authenticated-orcid":false,"given":"L\u00eda","family":"Hojman","sequence":"additional","affiliation":[{"name":"Dermatology Section, Surgery Department, Facultad de Medicina Cl\u00ednica Alemana de Santiago, Universidad del Desarrollo, Santiago P.O. Box 7630000, Chile"},{"name":"Investigation in Dermatology and Autoimmunity\u2014IDeA Lab, Instituto de Ciencias e Innovaci\u00f3n en Medicina, Universidad del Desarrollo, Santiago P.O. Box 7630000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"ref_1","unstructured":"(2022). Mediated Cross Talk?. Front. Immunol., 13, 868277."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.amjcard.2010.08.016","article-title":"Usefulness of the framingham risk score in patients with chronic psoriasis","volume":"106","author":"Gisondi","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1080\/09546634.2021.1966357","article-title":"Soluble biomarkers for diagnosis, monitoring, and therapeutic response assessment in psoriasis","volume":"33","author":"Pourani","year":"2022","journal-title":"J. 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