{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:51:10Z","timestamp":1792263070928,"version":"4.4.0"},"reference-count":59,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T00:00:00Z","timestamp":1673740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deputyship for Research &amp; Innovation, Ministry of Education, Saudi Arabia","award":["QU-IF-02-01-28388"],"award-info":[{"award-number":["QU-IF-02-01-28388"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Diabetes mellitus is a metabolic syndrome characterized by increased glucose levels, oxidative stress, hyperlipidemia, and frequently decreased insulin levels. The current research was carried out for eight consecutive weeks to evaluate the possible reno-protective effects of quercetin (50 mg\/kg b.w.) on streptozotocin (STZ) (55 mg\/kg b.w.) induced diabetes rat models. Various physiological, biochemical, and histopathological parameters were determined in control, diabetic control, and quercetin-treated diabetic rats. The current findings demonstrated that diabetes control rats showed significantly decreased body weights (198 \u00b1 10 vs. 214 \u00b1 13 g) and insulin levels (0.28 \u00b1 0.04 vs. 1.15 \u00b1 0.05 ng\/mL) in comparison to normal control. Besides this, the other parameters showed increased values, such as fasting blood glucose, triglyceride (TG), and total cholesterol levels (99 \u00b1 5 vs. 230 \u00b1 7 mg\/dL, 122.9 \u00b1 8.7 vs. 230.7 \u00b1 7.2 mg\/dL, 97.34 \u00b1 5.7 vs. 146.3 \u00b1 8 mg\/dL) (p &lt; 0.05). In addition, the urea and creatinine levels (39.9 \u00b1 1.8 mg\/dL and 102.7 \u00b1 7.8 \u03bcmol\/L) were also high in diabetes control rats. After 8 weeks of quercetin treatment in STZ-treated animals, body weight, insulin, and fasting blood sugar levels were significantly restored (p &lt; 0.05). The inflammatory markers (TNF-\u03b1, IL-6, and IL-1\u03b2) were significantly increased (52.64 \u00b1 2, 95.64 \u00b1 3, 23.3 \u00b1 1.2 pg\/mL) and antioxidant enzymes levels (SOD, GST, CAT, and GSH) were significantly decreased (40.3 \u00b1 3 U\/mg, 81.9 \u00b1 10 mU\/mg, 14.2 \u00b1 2 U\/mg, 19.9 \u00b1 2 \u03bcmol\/g) in diabetic rats. All the parameters in diabetic animals treated with quercetin were restored towards their normal values. Histopathological findings revealed that the quercetin-treated group showed kidney architecture maintenance, reduction of fibrosis, and decreased expression of COX-2 protein. These results determined that quercetin has reno-protective effects, and conclude that quercetin possesses a strong antidiabetic potential and might act as a therapeutic agent in the prevention or delay of diabetes-associated kidney dysfunction.<\/jats:p>","DOI":"10.3390\/metabo13010130","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T01:31:15Z","timestamp":1673832675000},"page":"130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal Tissue Damage, Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats"],"prefix":"10.3390","volume":"13","author":[{"given":"Arshad Husain","family":"Rahmani","sequence":"first","affiliation":[{"name":"Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9357-2216","authenticated-orcid":false,"given":"Mohammed A.","family":"Alsahli","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6030-4493","authenticated-orcid":false,"given":"Amjad Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Basic Health Science, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-0265","authenticated-orcid":false,"given":"Saleh A.","family":"Almatroodi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,15]]},"reference":[{"key":"ref_1","unstructured":"International Diabetes Federation (2017). 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