{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:56:43Z","timestamp":1790780203356,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Iran National Science Foundation (INSF)","award":["92000554"],"award-info":[{"award-number":["92000554"]}]},{"name":"the Iran National Science Foundation (INSF)","award":["398385"],"award-info":[{"award-number":["398385"]}]},{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["92000554"],"award-info":[{"award-number":["92000554"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["398385"],"award-info":[{"award-number":["398385"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Isolated diterpenes from various species of Euphorbia are important compounds for drug discovery with a broad spectrum of structures and biological effects. In this study, Euphorbia gedrosiaca, one of the endemic species of Iran, was analyzed in terms of the presence and structural determination of diterpenoid compounds. They were extracted with dichloromethane\/acetone (2:1) from aerial parts of this plant and purified by chromatographic methods such as MPLC and HPLC. Four premyrsinane compounds and one myrsinane diterpene were isolated from Euphorbia gedrosiaca. They were characterized by extensive 1D and 2D NMR and HRMS analyses. Additionally, their activities were evaluated against two breast cancer cell lines, MDA-MB-231 and MCF-7, by MTT proliferation assay. They exhibited cytotoxic effects in a dose-dependent manner with promising results, which can help to find possible therapeutic application of diterpenoids in breast cancer treatment.<\/jats:p>","DOI":"10.3390\/metabo13020225","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T02:29:23Z","timestamp":1675650563000},"page":"225","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diterpenoids from Euphorbia gedrosiaca as Potential Anti-Proliferative Agents against Breast Cancer Cells"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0102-4306","authenticated-orcid":false,"given":"Zeinab","family":"Yazdiniapour","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Newsha","family":"Motinia","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Zolfaghari","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Mehdifar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ghanadian","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3026-6593","authenticated-orcid":false,"given":"Virginia","family":"Lanzotti","sequence":"additional","affiliation":[{"name":"Dipartimento di Agraria, Universit\u00e0 di Napoli Federico II, 80055 Portici, Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.3732\/ajb.1500223","article-title":"Euphorbia plant latex is inhabited by diverse microbial communities","volume":"102","author":"Gunawardana","year":"2015","journal-title":"Am. 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