{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:17:29Z","timestamp":1792102649757,"version":"4.4.0"},"reference-count":109,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian agencies National Council for Scientific and Technological Development (CNPq)","award":["306729\/2019-9"],"award-info":[{"award-number":["306729\/2019-9"]}]},{"name":"Brazilian agencies National Council for Scientific and Technological Development (CNPq)","award":["PROEX TERMO AUXPE 0521\/2019"],"award-info":[{"award-number":["PROEX TERMO AUXPE 0521\/2019"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)","award":["306729\/2019-9"],"award-info":[{"award-number":["306729\/2019-9"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)","award":["PROEX TERMO AUXPE 0521\/2019"],"award-info":[{"award-number":["PROEX TERMO AUXPE 0521\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>An intense effort has been focused on new therapeutic approaches and the development of technologies for more efficient and rapid wound healing. The research for plants used for long time in traditional medicine in the treatment of wound has become a promising strategy to obtain drugs therapeutically useful in the acute and chronic wound management. In this context, Centella asiatica (Apiaceae) has been used to treat a variety of skin diseases, such as leprosy, lupus, varicose ulcers, eczema and psoriasis, in Asiatic traditional medicine for thousands of years. Studies have shown that Centella asiatica extracts (CAE) display activity in tissue regeneration, cell migration and wound repair process by promoting fibroblast proliferation and collagen synthesis. Preliminary findings have shown that the asiatic acid is one of the main active constituents of C. asiatica, directly associated with its healing activity. Thus, this study discusses aspects of the effects of Centella asiatica and its active component, asiatic acid, in different stages of the healing process of cutaneous wounds, including phytochemical and antimicrobial aspects that contribute to its therapeutic potential.<\/jats:p>","DOI":"10.3390\/metabo13020276","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T02:01:10Z","timestamp":1676426470000},"page":"276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":153,"title":["Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential"],"prefix":"10.3390","volume":"13","author":[{"given":"L\u00facio Ricardo Leite","family":"Diniz","sequence":"first","affiliation":[{"name":"National Institute of the Semiarid, Campina Grande 58434-700, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Luiz","family":"Calado","sequence":"additional","affiliation":[{"name":"National Institute of the Semiarid, Campina Grande 58434-700, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6192-3691","authenticated-orcid":false,"given":"Allana Brunna Sucupira","family":"Duarte","sequence":"additional","affiliation":[{"name":"Departament of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-970, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dami\u00e3o Pergentino","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Departament of Pharmaceutical Sciences, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-970, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"ref_1","first-page":"24","article-title":"A review of skin and the effects of aging on skin structure and function","volume":"52","author":"Fore","year":"2006","journal-title":"Ostomy Wound Manag."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"a015339","DOI":"10.1101\/cshperspect.a015339","article-title":"Immunology and skin in health and disease","volume":"4","author":"Richmond","year":"2014","journal-title":"Cold Spring Harb. 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