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In spite of the richness of the literature, there is no consensus about the utility of metabolomic analyses for the management of COVID-19, calling for a critical assessment of the literature. We identified mass spectrometric metabolomic studies on specimens from SARS-CoV2-infected patients and subjected them to a cross-study comparison. We compared the clinical design, technical aspects, and statistical analyses of published studies with the purpose to identify the most relevant biomarkers. Several among the metabolites that are under- or overrepresented in the plasma from patients with COVID-19 may directly contribute to excessive inflammatory reactions and deficient immune control of SARS-CoV2, hence unraveling important mechanistic connections between whole-body metabolism and the course of the disease. Altogether, it appears that mass spectrometric approaches have a high potential for biomarker discovery, especially if they are subjected to methodological standardization.<\/jats:p>","DOI":"10.3390\/metabo13030342","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T02:15:37Z","timestamp":1677464137000},"page":"342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Diagnostic, Prognostic and Mechanistic Biomarkers of COVID-19 Identified by Mass Spectrometric Metabolomics"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-6807","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Bourgin","sequence":"first","affiliation":[{"name":"Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France"},{"name":"Centre de Recherche des Cordeliers, Equipe Labellis\u00e9e par la Ligue Contre le Cancer, Universit\u00e9 de Paris Cit\u00e9, Sorbonne Universit\u00e9, Inserm U1138, Institut Universitaire de France, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylv\u00e8re","family":"Durand","sequence":"additional","affiliation":[{"name":"Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France"},{"name":"Centre de Recherche des Cordeliers, Equipe Labellis\u00e9e par la Ligue Contre le Cancer, Universit\u00e9 de Paris Cit\u00e9, Sorbonne Universit\u00e9, Inserm U1138, Institut Universitaire de France, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9334-4405","authenticated-orcid":false,"given":"Guido","family":"Kroemer","sequence":"additional","affiliation":[{"name":"Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France"},{"name":"Centre de Recherche des Cordeliers, Equipe Labellis\u00e9e par la Ligue Contre le Cancer, Universit\u00e9 de Paris Cit\u00e9, Sorbonne Universit\u00e9, Inserm U1138, Institut Universitaire de France, 75005 Paris, France"},{"name":"Institut du Cancer Paris CARPEM, Department of Biology, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, 75610 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021). 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