{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:40:49Z","timestamp":1790548849834,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Metabolomics in clinical toxicology aim at reliably identifying and semi-quantifying a broad array of endogenous and exogenous metabolites using dedicated analytical methods. Here, we developed a three-step-based workflow to investigate the metabolic impact of the antidepressant drug venlafaxine in a poisoned patient who developed life-threatening cardiac failure managed with extracorporeal membrane oxygenation. Both targeted quantitative and untargeted semi-quantitative metabolomic analyses using liquid chromatography hyphenated to high-resolution tandem mass spectrometry were performed to determine the plasma kinetics of venlafaxine, O-desmethyl-venlafaxine, and N-desmethyl-venlafaxine and to identify sixteen different venlafaxine-derived metabolites including one unknown (i.e., venlafaxine conjugated to a hexosyl-radical), respectively. Correlations between the quantitative metabolomic data and annotated endogenous metabolites suggested impaired amino acid and lipid metabolism, Krebs cycle, and kynurenine pathway. This preliminary study represents a first step towards a more extensive application of toxicometabolomics in clinical toxicology and a useful workflow to identify the biomarkers of toxicity.<\/jats:p>","DOI":"10.3390\/metabo13030353","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T02:28:09Z","timestamp":1677551289000},"page":"353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Life-Threatening Cardiogenic Shock Related to Venlafaxine Poisoning\u2014A Case Report with Metabolomic Approach"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-8509","authenticated-orcid":false,"given":"Romain","family":"Magny","sequence":"first","affiliation":[{"name":"Laboratoire de Toxicologie, F\u00e9d\u00e9ration de Toxicologie, AH-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"},{"name":"Inserm, UMRS-1144, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-2764","authenticated-orcid":false,"given":"Bruno","family":"M\u00e9garbane","sequence":"additional","affiliation":[{"name":"Inserm, UMRS-1144, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"},{"name":"R\u00e9animation M\u00e9dicale et Toxicologique, F\u00e9d\u00e9ration de Toxicologie de l\u2019AH-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Guillaud","sequence":"additional","affiliation":[{"name":"Laboratoire de Toxicologie, F\u00e9d\u00e9ration de Toxicologie, AH-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-9117","authenticated-orcid":false,"given":"Lucie","family":"Chevillard","sequence":"additional","affiliation":[{"name":"Inserm, UMRS-1144, 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