{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:49:41Z","timestamp":1773866981950,"version":"3.50.1"},"reference-count":67,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mental Health Research Institute","award":["122020200054-8"],"award-info":[{"award-number":["122020200054-8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Metabolic syndrome (MetS) is a common comorbidity of schizophrenia and significantly shortens life expectancy of the patients. Intercellular (ICAM), vascular (VCAM), and neural (NCAM) cell adhesion molecules (CAMs) mediate neuroinflammatory processes, and their soluble forms (e.g., sICAM) in plasma are present in parallel with their cell-bound forms. In this study, their serum levels were examined in 211 white Siberian patients with paranoid schizophrenia (82 patients with and 129 without MetS according to the 2005 International Diabetes Federation criteria). Serum levels of CAMs were determined with Magpix and Luminex 200 (Luminex, Austin, TX, USA) using xMAP Technology. The level of sICAM-1 was significantly higher and that of sVCAM-1 significantly lower in patients with MetS compared to patients without MetS. Levels of NCAM did not differ between the groups. More pronounced Spearman\u2019s correlations between CAMs, age, duration of schizophrenia, and body\u2013mass index were observed among patients without MetS than among patients with MetS. Our results are consistent with MetS\u2019s being associated with endothelial dysfunction along with other components of inflammation. Through these endothelial components of peripheral inflammatory processes, MetS might induce intracerebral neuroinflammatory changes, but further investigation is needed to confirm this.<\/jats:p>","DOI":"10.3390\/metabo13030376","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T02:03:08Z","timestamp":1677808988000},"page":"376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cell Adhesion Molecules in Schizophrenia Patients with Metabolic Syndrome"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2955-9057","authenticated-orcid":false,"given":"Anastasiia S.","family":"Boiko","sequence":"first","affiliation":[{"name":"Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya, Str. 4, 634014 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8057-3305","authenticated-orcid":false,"given":"Irina A.","family":"Mednova","sequence":"additional","affiliation":[{"name":"Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya, Str. 4, 634014 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5179-9727","authenticated-orcid":false,"given":"Elena G.","family":"Kornetova","sequence":"additional","affiliation":[{"name":"Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya, Str. 4, 634014 Tomsk, Russia"},{"name":"Department of Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, Moskovsky Trakt, 2, 634050 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-0251","authenticated-orcid":false,"given":"Arkadiy V.","family":"Semke","sequence":"additional","affiliation":[{"name":"Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya, Str. 4, 634014 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay A.","family":"Bokhan","sequence":"additional","affiliation":[{"name":"Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya, Str. 4, 634014 Tomsk, Russia"},{"name":"Department of Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, Moskovsky Trakt, 2, 634050 Tomsk, Russia"},{"name":"Department of Psychotherapy and Psychological Counseling, National Research Tomsk State University, 634050 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7078-323X","authenticated-orcid":false,"given":"Svetlana A.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Aleutskaya, Str. 4, 634014 Tomsk, Russia"},{"name":"Department of Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, Moskovsky Trakt, 2, 634050 Tomsk, Russia"},{"name":"Department of Psychotherapy and Psychological Counseling, National Research Tomsk State University, 634050 Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.schres.2010.08.030","article-title":"Prevalence of metabolic syndrome among patients with schizophrenia in Japan","volume":"123","author":"Sugawara","year":"2010","journal-title":"Schizophr. 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