{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:41:39Z","timestamp":1760125299106,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The University of Arizona Cancer Center","award":["P30 CA023074"],"award-info":[{"award-number":["P30 CA023074"]}]},{"name":"Clinical Research Oversight Counsel (CROC)","award":["P30 CA023074"],"award-info":[{"award-number":["P30 CA023074"]}]},{"name":"National Cancer Institute of the National Institutes of Health","award":["P30 CA023074"],"award-info":[{"award-number":["P30 CA023074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Aromatase inhibitor-induced arthralgia (AIA) presents a major problem for patients with breast cancer but is poorly understood. This prospective study explored the inflammatory metabolomic changes in the development of AIA. This single-arm, prospective clinical trial enrolled 28 postmenopausal women with early-stage (0\u20133) ER+ breast cancer starting adjuvant anastrozole. Patients completed the Breast Cancer Prevention Trial (BCPT) Symptom Checklist and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) at 0, 3, and 6 months. The plasma levels of four polyunsaturated fatty acids (PUFAs) and 48 oxylipins were quantified at each timepoint. The subscores for WOMAC-pain and stiffness as well as BCPT-total, hot flash, and musculoskeletal pain significantly increased from baseline to 6 months (all p &lt; 0.05). PUFA and oxylipin levels were stable over time. The baseline levels of 8-HETE were positively associated with worsening BCPT-total, BCPT-hot flash, BCPT-musculoskeletal pain, WOMAC-pain, and WOMAC- stiffness at 6 months (all p &lt; 0.05). Both 9-HOTrE and 13(S)-HOTrE were related to worsening hot flash, and 5-HETE was related to worsening stiffness (all p &lt; 0.05). This is the first study to prospectively characterize oxylipin and PUFA levels in patients with breast cancer starting adjuvant anastrozole. The oxylipin 8-HETE should be investigated further as a potential biomarker for AIA.<\/jats:p>","DOI":"10.3390\/metabo13030452","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T07:06:37Z","timestamp":1679295997000},"page":"452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oxylipins as Biomarkers for Aromatase Inhibitor-Induced Arthralgia (AIA) in Breast Cancer Patients"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5811-1019","authenticated-orcid":false,"given":"Jessica A.","family":"Martinez","sequence":"first","affiliation":[{"name":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA"},{"name":"Department of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ 85724, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy C.","family":"Wertheim","sequence":"additional","affiliation":[{"name":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6989-6579","authenticated-orcid":false,"given":"Denise J.","family":"Roe","sequence":"additional","affiliation":[{"name":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA"},{"name":"Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ 85724, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihra S.","family":"Taljanovic","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of New Mexico, Albuquerque, NM 87106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-H. Sherry","family":"Chow","sequence":"additional","affiliation":[{"name":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wade","family":"Chew","sequence":"additional","affiliation":[{"name":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sima","family":"Ehsani","sequence":"additional","affiliation":[{"name":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA"},{"name":"Department of Medicine, University of Arizona, Tucson, AZ 85724, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sao","family":"Jiralerspong","sequence":"additional","affiliation":[{"name":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA"},{"name":"Department of Medicine, University of Arizona, Tucson, AZ 85724, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6345-2093","authenticated-orcid":false,"given":"Jennifer","family":"Segar","sequence":"additional","affiliation":[{"name":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA"},{"name":"Department of Medicine, University of Arizona, Tucson, AZ 85724, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavani","family":"Chalasani","sequence":"additional","affiliation":[{"name":"The University of Arizona Cancer Center, Tucson, AZ 85724, USA"},{"name":"Department of Medicine, University of Arizona, Tucson, AZ 85724, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJMoa1604700","article-title":"Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years","volume":"375","author":"Goss","year":"2016","journal-title":"N. 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