{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:51:03Z","timestamp":1772592663355,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programa Operativo FEDER 2014\u20132020","award":["(B-AGR-257-UGR18)"],"award-info":[{"award-number":["(B-AGR-257-UGR18)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Virgin olive oil (VOO) is a high-value product from the Mediterranean diet. Some health and nutritional benefits have been associated with its consumption, not only because of its monounsaturated-rich triacylglycerols but also due to its minor bioactive components. The search for specific metabolites related to VOO consumption may provide valuable information to identify the specific bioactive components and to understand possible molecular and metabolic mechanisms implicated in those health effects. In this regard, metabolomics, considered a key analytical tool in nutritional studies, offers a better understanding of the regulatory functions of food components on human nutrition, well-being, and health. For that reason, the aim of the present review is to summarize the available scientific evidence related to the metabolic effects of VOO or its minor bioactive compounds in human, animal, and in vitro studies using metabolomics approaches.<\/jats:p>","DOI":"10.3390\/metabo13040472","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T03:31:48Z","timestamp":1679887908000},"page":"472","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Metabolomic-Based Studies of the Intake of Virgin Olive Oil: A Comprehensive Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8375-266X","authenticated-orcid":false,"given":"Alejandra","family":"Vazquez-Aguilar","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology II, University of Granada, Campus Cartuja s\/n, 18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Biomedical Research Center, University of Granada, Parque Tecnol\u00f3gico de la Salud, Avenida del Conocimiento s\/n, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8164-6513","authenticated-orcid":false,"given":"Estefania","family":"Sanchez-Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology II, University of Granada, Campus Cartuja s\/n, 18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Biomedical Research Center, University of Granada, Parque Tecnol\u00f3gico de la Salud, Avenida del Conocimiento s\/n, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada ibs, 18012 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7233-6481","authenticated-orcid":false,"given":"Celia","family":"Rodriguez-Perez","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Biomedical Research Center, University of Granada, Parque Tecnol\u00f3gico de la Salud, Avenida del Conocimiento s\/n, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada ibs, 18012 Granada, Spain"},{"name":"Department of Nutrition and Food Science, University of Granada, Campus Melilla C\/Santander, 52005 Melilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-0108","authenticated-orcid":false,"given":"Oscar","family":"Rangel-Huerta","sequence":"additional","affiliation":[{"name":"Section of Chemistry and Toxinology, Norwegian Veterinary Institute, P.O. 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