{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:46:53Z","timestamp":1790750813643,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Inflammatory processes are common in intensive care (ICU) patients and can induce multiple changes in metabolism, leading to increased risks of morbidity and mortality. Metabolomics enables these modifications to be studied and identifies a patient\u2019s metabolic profile. The objective is to precise if the use of metabolomics at ICU admission can help in prognostication. This is a prospective ex-vivo study, realized in a university laboratory and a medico-surgical ICU. Metabolic profiles were analyzed by proton nuclear magnetic resonance. Using multivariable analysis, we compared metabolic profiles of volunteers and ICU patients divided into predefined subgroups: sepsis, septic shock, other shock and ICU controls. We also assessed possible correlations between metabolites and mortality. One hundred and eleven patients were included within 24 h of ICU admission, and 19 healthy volunteers. The ICU mortality rate was 15%. Metabolic profiles were different in ICU patients compared to healthy volunteers (p &lt; 0.001). Among the ICU patients, only the subgroup of patients with septic shock had significant differences compared to the ICU control patients in several metabolites: pyruvate, lactate, carnitine, phenylalanine, urea, creatine, creatinine and myo-inositol. However, there was no correlation between these metabolite profiles and mortality. On the first day of ICU admission, we observed changes in some metabolic products in patients with septic shock, suggesting increased anaerobic glycolysis, proteolysis, lipolysis and gluconeogenesis. These changes were not correlated with prognosis.<\/jats:p>","DOI":"10.3390\/metabo13040523","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T01:10:27Z","timestamp":1680743427000},"page":"523","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum Metabolomic Profiles in Critically Ill Patients with Shock on Admission to the Intensive Care Unit"],"prefix":"10.3390","volume":"13","author":[{"given":"Aur\u00e9lie","family":"Thooft","sequence":"first","affiliation":[{"name":"Intensive Care, CHU-Charleroi, Universit\u00e9 Libre de Bruxelles, 140, Chauss\u00e9e de Bruxelles, 6042 Charleroi, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Conotte","sequence":"additional","affiliation":[{"name":"Laboratory of Human Biology and Toxicology, Research Institute for Health Sciences and Technology, University of Mons, 7000 Mons, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4440-2795","authenticated-orcid":false,"given":"Jean-Marie","family":"Colet","sequence":"additional","affiliation":[{"name":"Laboratory of Human Biology and Toxicology, Research Institute for Health Sciences and Technology, University of Mons, 7000 Mons, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Zouaoui Boudjeltia","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Medicine, ULB 222 Unit, Universit\u00e9 Libre de Bruxelles, CHU-Charleroi, 6110 Charleroi, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Biston","sequence":"additional","affiliation":[{"name":"Intensive Care, CHU-Charleroi, Universit\u00e9 Libre de Bruxelles, 140, Chauss\u00e9e de Bruxelles, 6042 Charleroi, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9201-827X","authenticated-orcid":false,"given":"Micha\u00ebl","family":"Piagnerelli","sequence":"additional","affiliation":[{"name":"Intensive Care, CHU-Charleroi, Universit\u00e9 Libre de Bruxelles, 140, Chauss\u00e9e de Bruxelles, 6042 Charleroi, Belgium"},{"name":"Laboratory of Experimental Medicine, ULB 222 Unit, Universit\u00e9 Libre de Bruxelles, CHU-Charleroi, 6110 Charleroi, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/bja\/aeu187","article-title":"Groeneveld ABJ: Metabolic response to the stress of critical illness","volume":"113","author":"Preiser","year":"2014","journal-title":"Br. 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