{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:19:07Z","timestamp":1788931147120,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness, Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI18\/012019"],"award-info":[{"award-number":["PI18\/012019"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is a global health problem associated with liver morbimortality, obesity, and type 2 diabetes mellitus. This study aimed to analyze the prevalence of NAFLD (defined as a fatty liver index [FLI] \u2265 60) and its association with other cardiovascular risk (CVR) factors in patients with prediabetes and overweight\/obesity. The present cross-sectional analysis uses baseline data from an ongoing randomized clinical trial. Sociodemographic and anthropometric characteristics, CVR (assessed by the REGICOR-Framingham risk equation), metabolic syndrome (MetS), and FLI-defined NAFLD (cut-off value of \u226560) were assessed. The prevalence of FLI-defined NAFLD was 78% overall. Men exhibited a worse cardiometabolic profile as compared to women, specifically, with higher values of systolic blood pressure (137.02 \u00b1 13.48 vs. 131.22 \u00b1 14.77 mmHg), diastolic blood pressure (85.33 \u00b1 9.27 vs. 82.3 \u00b1 9.12 mmHg), aspartate aminotransferase (AST) (27.23 \u00b1 12.15 vs. 21.23 \u00b1 10.05 IU\/L), alanine aminotransferase (ALT) (34.03 \u00b1 23.31 vs. 21.73 \u00b1 10.80 IU\/L), and higher CVR (5.58 \u00b1 3.16 vs. 3.60 \u00b1 1.68). FLI-defined NAFLD was associated with elevated AST, ALT, and the presence of MetS (73.7%) and CVR for the whole sample. People with prediabetes present a high burden of comorbidities related to CVR, despite clinical follow-up, and it is recommended to actively begin working with them to reduce their risks.<\/jats:p>","DOI":"10.3390\/metabo13040531","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T03:26:06Z","timestamp":1681097166000},"page":"531","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fatty Liver Disease in Patients with Prediabetes and Overweight or Obesity"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7245-0030","authenticated-orcid":false,"given":"Mar\u00eda","family":"Arias-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Nursing and Physiotherapy, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Research Group on Global Health, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Research 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Global Health, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Research Group on Global Health and Lifestyle, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, Spain"},{"name":"ADEMA-SALUD Group of IUNICS, University of Balearic Islands, 07009 Palma, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Torres-Carballo","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Research Group on Global Health, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Primary Care Research Unit of Mallorca, Public Health Service of the Balearic Islands (Ibsalut), 07003 Palma, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aina","family":"Huguet-Torres","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Research Group on Global Health, University of Balearic Islands, 07122 Palma, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-3610","authenticated-orcid":false,"given":"Cristian","family":"S\u00e1nchez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Research Group on Global Health, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Sant Joan de D\u00e9u Hospital, 07007 Palma, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-2141","authenticated-orcid":false,"given":"Miquel","family":"Bennasar-Veny","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Research Group on Global Health, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Research Group on Global Health and Lifestyle, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-3937","authenticated-orcid":false,"given":"Aina M.","family":"Ya\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Nursing and Physiotherapy, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Research Group on Global Health, University of Balearic Islands, 07122 Palma, Spain"},{"name":"Research Group on Global Health and Lifestyle, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-2137","authenticated-orcid":false,"given":"Carla","family":"Busquets-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Research Group on Global Health, University of Balearic Islands, 07122 Palma, 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