{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:32:03Z","timestamp":1784831523669,"version":"3.55.0"},"reference-count":136,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GENES Intra-Africa Academic Mobility Project; \u201cMobility for plant genomics scholars to accelerate climate-smart adaptation options and food security in Africa (GENES)\u201d funded by European Union","award":["EACEA\/2017\/2552"],"award-info":[{"award-number":["EACEA\/2017\/2552"]}]},{"name":"GENES Intra-Africa Academic Mobility Project","award":["EACEA\/2017\/2552"],"award-info":[{"award-number":["EACEA\/2017\/2552"]}]},{"name":"Queen\u2019s University Belfast, Northern Ireland, United Kingdom","award":["EACEA\/2017\/2552"],"award-info":[{"award-number":["EACEA\/2017\/2552"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Yams are economic and medicinal crops with a long growth cycle, spanning between 9\u201311 months due to their prolonged tuber dormancy. Tuber dormancy has constituted a major constraint in yam production and genetic improvement. In this study, we performed non-targeted comparative metabolomic profiling of tubers of two white yam genotypes, (Obiaoturugo and TDr1100873), to identify metabolites and associated pathways that regulate yam tuber dormancy using gas chromatography\u2013mass spectrometry (GC\u2013MS). Yam tubers were sampled between 42 days after physiological maturity (DAPM) till tuber sprouting. The sampling points include 42-DAPM, 56-DAPM, 87DAPM, 101-DAPM, 115-DAPM, and 143-DAPM. A total of 949 metabolites were annotated, 559 in TDr1100873 and 390 in Obiaoturugo. A total of 39 differentially accumulated metabolites (DAMs) were identified across the studied tuber dormancy stages in the two genotypes. A total of 27 DAMs were conserved between the two genotypes, whereas 5 DAMs were unique in the tubers of TDr1100873 and 7 DAMs were in the tubers of Obiaoturugo. The differentially accumulated metabolites (DAMs) spread across 14 major functional chemical groups. Amines and biogenic polyamines, amino acids and derivatives, alcohols, flavonoids, alkaloids, phenols, esters, coumarins, and phytohormone positively regulated yam tuber dormancy induction and maintenance, whereas fatty acids, lipids, nucleotides, carboxylic acids, sugars, terpenoids, benzoquinones, and benzene derivatives positively regulated dormancy breaking and sprouting in tubers of both yam genotypes. Metabolite set enrichment analysis (MSEA) revealed that 12 metabolisms were significantly enriched during yam tuber dormancy stages. Metabolic pathway topology analysis further revealed that six metabolic pathways (linoleic acid metabolic pathway, phenylalanine metabolic pathway, galactose metabolic pathway, starch and sucrose metabolic pathway, alanine-aspartate-glutamine metabolic pathways, and purine metabolic pathway) exerted significant impact on yam tuber dormancy regulation. This result provides vital insights into molecular mechanisms regulating yam tuber dormancy.<\/jats:p>","DOI":"10.3390\/metabo13050610","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T09:54:53Z","timestamp":1682675693000},"page":"610","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparative Metabolomics Profiling Reveals Key Metabolites and Associated Pathways Regulating Tuber Dormancy in White Yam (Dioscorea rotundata Poir.)"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0283-1417","authenticated-orcid":false,"given":"Jeremiah S.","family":"Nwogha","sequence":"first","affiliation":[{"name":"Department of Horticulture and Plant Sciences, College of Agriculture and Veterinary Medicine, Jimma University, Jimma P.O. Box 307, Ethiopia"},{"name":"Centre for Plant Molecular Biology & Biotechnology, Departments of Plant Biotechnology and Biochemistry, Tamil Nadu Agricultural University, Coimbatore 641003, India"},{"name":"Yam Research Programme, National Root Crops Research Institute, Umudike 440001, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abtew G.","family":"Wosene","sequence":"additional","affiliation":[{"name":"Department of Horticulture and Plant Sciences, College of Agriculture and Veterinary Medicine, Jimma University, Jimma P.O. Box 307, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8803-7662","authenticated-orcid":false,"given":"Muthurajan","family":"Raveendran","sequence":"additional","affiliation":[{"name":"Centre for Plant Molecular Biology & Biotechnology, Departments of Plant Biotechnology and Biochemistry, Tamil Nadu Agricultural University, Coimbatore 641003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude E.","family":"Obidiegwu","sequence":"additional","affiliation":[{"name":"Yam Research Programme, National Root Crops Research Institute, Umudike 440001, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Happiness O.","family":"Oselebe","sequence":"additional","affiliation":[{"name":"Department of Crop Production and Landscape Management, Ebonyi State University, Abakaliki 480282, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Kambale","sequence":"additional","affiliation":[{"name":"Centre for Plant Molecular Biology & Biotechnology, Departments of Plant Biotechnology and Biochemistry, Tamil Nadu Agricultural University, Coimbatore 641003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A.","family":"Chilaka","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security, School of Biological Sciences, Queen\u2019s University Belfast, 19 Chlorine Gardens, Belfast BT9 5DL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2875-5451","authenticated-orcid":false,"given":"Veera Ranjani","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Centre for Plant Molecular Biology & Biotechnology, Departments of Plant Biotechnology and Biochemistry, Tamil Nadu Agricultural University, Coimbatore 641003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29136","DOI":"10.1038\/srep29136","article-title":"Metabolite profiling of Dioscorea (yam) species reveals underutilised biodiversity and renewable sources for high-value compounds","volume":"6","author":"Price","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Obidiegwu, J.E., Lyons, J.B., and Chilaka, C.A. (2020). The Dioscorea Genus (Yam)\u2014An appraisal of nutritional and therapeutic potentials. Foods, 9.","DOI":"10.3390\/foods9091304"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.5897\/AJB2003.000-1097","article-title":"Harnessing modern biotechnology for tropical tuber crop improvement: Yam (Dioscorea spp.) molecular breeding","volume":"2","author":"Mignouna","year":"2003","journal-title":"Afr. J. Biotechnol."},{"key":"ref_4","unstructured":"Lev, L.S., and Shriver, A.L. (1998). A trend analysis of yam production, area, yield, and trade (1961\u20131996). Colloq.-CIRAD, 11\u201320."},{"key":"ref_5","first-page":"223","article-title":"Varietal diversity and genetic erosion of cultivated yams (Dioscorea cayenensis Poir-D. rotundata Lam complex and D. alata L.) in Togo","volume":"5","author":"Dansi","year":"2013","journal-title":"Int. J. Biodivers. Conserv."},{"key":"ref_6","unstructured":"FAOSTAT (2022, October 23). Food and Agriculture Organization of the United Nations. Available online: http:\/\/wwwfaoorg\/faostat\/en\/#data\/QC."},{"key":"ref_7","first-page":"47","article-title":"Physiological and Molecular basis of dormancy in yam tuber: A way forward towards genetic manipultion of dormancy in yam tubers","volume":"XXll","author":"Nwogha","year":"2022","journal-title":"Glob. J. Sci. Front. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.21273\/HORTSCI.22.3.371","article-title":"Endo-, para-, and ecodormancy: Physiological terminology and classification for dormancy research","volume":"22","author":"Lang","year":"1987","journal-title":"HortScience"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/nph.13955","article-title":"Understanding the roles of nonstructural carbohydrates in forest trees\u2013from what we can measure to what we want to know","volume":"211","author":"Hartmann","year":"2016","journal-title":"New Phytol."},{"key":"ref_10","first-page":"277","article-title":"Evaluation of yam (Dioscorea cayenensis\u2013Dioscorea rotundata) seed germination grown in Centre Benin","volume":"3","author":"Mounirou","year":"2015","journal-title":"Int. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/aob\/mcl002","article-title":"Phases of dormancy in yam tubers (Dioscorea rotundata)","volume":"97","author":"Ile","year":"2006","journal-title":"Ann. Bot."},{"key":"ref_12","unstructured":"Passam, H. (1982). Yams. Ignames, Oxford University Press."},{"key":"ref_13","first-page":"34","article-title":"Changes in Free Phenolics Contents during Tuber Development, Dormancy and Sprouting in White Yam (Dioscorea rotundata Poir.)","volume":"5","author":"Hamadina","year":"2015","journal-title":"Int. J. Plant Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Shangguan, L., Chen, M., Fang, X., Xie, Z., Gong, P., Huang, Y., Wang, Z., and Fang, J. (2020). Comparative transcriptome analysis provides insight into regulation pathways and temporal and spatial expression characteristics of grapevine (Vitis vinifera) dormant buds in different nodes. BMC Plant Biol., 20.","DOI":"10.1186\/s12870-020-02583-1"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"10064","DOI":"10.1021\/acs.jafc.7b02986","article-title":"Effect of germination and fermentation on carbohydrate composition of Australian sweet lupin and soybean seeds and flours","volume":"65","author":"Kaczmarska","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Orenga, S., Ferrer-Gallego, P.P., Laguna, E., L\u00f3pez-Gresa, M.P., Donat-Torres, M.P., Verdeguer, M., Vicente, O., and Boscaiu, M. (2019). Insights on salt tolerance of two endemic Limonium species from Spain. Metabolites, 9.","DOI":"10.3390\/metabo9120294"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molp.2015.08.010","article-title":"Two faces of one seed: Hormonal regulation of dormancy and germination","volume":"9","author":"Shu","year":"2016","journal-title":"Mol. Plant"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Guo, H., Lyv, Y., Zheng, W., Yang, C., Li, Y., Wang, X., Chen, R., Wang, C., Luo, J., and Qu, L. (2021). Comparative metabolomics reveals two metabolic modules affecting seed germination in rice (Oryza sativa). Metabolites, 11.","DOI":"10.3390\/metabo11120880"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"12620","DOI":"10.1038\/s41598-017-13093-w","article-title":"Exogenous auxin represses soybean seed germination through decreasing the gibberellin\/abscisic acid (GA\/ABA) ratio","volume":"7","author":"Shuai","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kralj Cigi\u0107, I., Rupnik, S., Rijavec, T., Poklar Ulrih, N., and Cigi\u0107, B. (2020). Accumulation of agmatine, spermidine, and spermine in sprouts and microgreens of alfalfa, fenugreek, lentil, and daikon radish. Foods, 9.","DOI":"10.3390\/foods9050547"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0006-291X(88)81178-1","article-title":"Polyamine distribution among maize embryonic tissues and its relation to seed germination","volume":"153","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/15228860802087297","article-title":"Seed priming with polyamines improves the germination and early seedling growth in fine rice","volume":"9","author":"Farooq","year":"2008","journal-title":"J. New Seeds"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"18003","DOI":"10.3390\/molecules191118003","article-title":"Exogenous spermidine improves seed germination of white clover under water stress via involvement in starch metabolism, antioxidant defenses and relevant gene expression","volume":"19","author":"Li","year":"2014","journal-title":"Molecules"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Huang, Y., Lin, C., He, F., Li, Z., Guan, Y., Hu, Q., and Hu, J. (2017). Exogenous spermidine improves seed germination of sweet corn via involvement in phytohormone interactions, H2O2 and relevant gene expression. BMC Plant Biol., 17.","DOI":"10.1186\/s12870-016-0951-9"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1002\/jsfa.8336","article-title":"Effect of germination on chemical, functional and nutritional characteristics of wheat, brown rice and triticale: A comparative study","volume":"97","author":"Sibian","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/tpj.13538","article-title":"Disruptions in valine degradation affect seed development and germination in Arabidopsis","volume":"90","author":"Gipson","year":"2017","journal-title":"Plant J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1104\/pp.81.2.692","article-title":"Amino acids content in germinating seeds and seedlings from Castanea sativa L.","volume":"81","author":"Desmaison","year":"1986","journal-title":"Plant Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zhang, T., Yuan, Y., Zhan, Y., Cao, X., Liu, C., Zhang, Y., and Gai, S. (2020). Metabolomics analysis reveals Embden Meyerhof Parnas pathway activation and flavonoids accumulation during dormancy transition in tree peony. BMC Plant Biol., 20.","DOI":"10.1186\/s12870-020-02692-x"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.21273\/HORTSCI.26.2.171","article-title":"Changes in metabolic enzyme activities during thidiazuron-induced lateral budbreak of apple","volume":"26","author":"Wang","year":"1991","journal-title":"HortScience"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00425-008-0720-6","article-title":"Similar mechanisms might be triggered by alternative external stimuli that induce dormancy release in grape buds","volume":"228","author":"Halaly","year":"2008","journal-title":"Planta"},{"key":"ref_31","first-page":"1201","article-title":"Respiratory changes during dormancy of grape buds","volume":"46","author":"Shen","year":"2013","journal-title":"Sci. Agric. Sin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.pld.2021.12.001","article-title":"Metabolome profiling of stratified seeds provides insight into the regulation of dormancy in Davidia involucrata","volume":"44","author":"Deng","year":"2022","journal-title":"Plant Divers."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1021\/pr3006815","article-title":"Cold stratification and exogenous nitrates entail similar functional proteome adjustments during Arabidopsis seed dormancy release","volume":"11","author":"Arc","year":"2012","journal-title":"J. Proteome Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11738-003-0025-0","article-title":"Proteins and polyamines during dormancy breaking of European beech (Fagus sylvatica L.) seeds","volume":"25","author":"Szczotka","year":"2003","journal-title":"Acta Physiol. Plant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1590\/1807-1929\/agriambi.v21n3p156-162","article-title":"Salicylic acid as attenuator of drought stress on germination and initial development of sesame","volume":"21","author":"Silva","year":"2017","journal-title":"Rev. Bras. Eng. Agr\u00edcola Ambient."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.plantsci.2016.02.015","article-title":"Galactinol as marker for seed longevity","volume":"246","author":"Willems","year":"2016","journal-title":"Plant Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pbi.2020.01.010","article-title":"SnRK1 and trehalose 6-phosphate\u2013two ancient pathways converge to regulate plant metabolism and growth","volume":"55","author":"Lunn","year":"2020","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.cub.2016.05.005","article-title":"TOR signaling promotes accumulation of BZR1 to balance growth with carbon availability in Arabidopsis","volume":"26","author":"Zhang","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Bledsoe, S.W., Henry, C., Griffiths, C.A., Paul, M.J., Feil, R., Lunn, J.E., Stitt, M., and Lagrimini, L.M. (2017). The role of Tre6P and SnRK1 in maize early kernel development and events leading to stress-induced kernel abortion. BMC Plant Biol., 17.","DOI":"10.1186\/s12870-017-1018-2"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1104\/pp.16.00417","article-title":"A tale of two sugars: Trehalose 6-phosphate and sucrose","volume":"172","author":"Figueroa","year":"2016","journal-title":"Plant Physiol."},{"key":"ref_41","first-page":"99","article-title":"Effect of chemical fertilizers on production of yams (ny\u00f9) of passore in farmers\u2019 environment","volume":"30","author":"Tiama","year":"2018","journal-title":"Agron. Afr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1105\/tpc.110.073866","article-title":"Integrative transcript and metabolite analysis of nutritionally enhanced DE-ETIOLATED1 downregulated tomato fruit","volume":"22","author":"Enfissi","year":"2010","journal-title":"Plant Cell"},{"key":"ref_43","unstructured":"Oliveros, J.C., and VENNY (2022, November 01). An Interactive Tool for Comparing Lists with Venn Diagrams. Available online: http:\/\/bioinfogp.cnb.csic.es\/tools\/venny\/index.html."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Nwogha, J.S., Abtew, W.G., Raveendran, M., Oselebe, H.O., Obidiegwu, J.E., Chilaka, C.A., and Amirtham, D.D. (2023). Role of Non-Structural Sugar Metabolism in Regulating Tuber Dormancy in White Yam (Dioscorea rotundata). Agriculture, 13.","DOI":"10.20944\/preprints202301.0182.v1"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.plaphy.2017.04.013","article-title":"Comparative metabolome analysis of wheat embryo and endosperm reveals the dynamic changes of metabolites during seed germination","volume":"115","author":"Han","year":"2017","journal-title":"Plant Physiol. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, Y., Zhang, M., Dong, S., Liu, Y.-L., and Li, Z.-H. (2021). The Opposite Roles of White Light in Regulating Germination of Fresh and Aged Seed in Tobacco. Plants, 10.","DOI":"10.3390\/plants10112457"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"110282","DOI":"10.1016\/j.plantsci.2019.110282","article-title":"Metabolic profile analysis and identification of key metabolites during rice seed germination under low-temperature stress","volume":"289","author":"Yang","year":"2019","journal-title":"Plant Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.scienta.2018.01.061","article-title":"Metabolomics analysis of developing Garcinia mangostana seed reveals modulated levels of sugars, organic acids and phenylpropanoid compounds","volume":"233","author":"Mazlan","year":"2018","journal-title":"Sci. Hortic."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.plaphy.2018.04.020","article-title":"Comparative metabolomic analysis of seed metabolites associated with seed storability in rice (Oryza sativa L.) during natural aging","volume":"127","author":"Yan","year":"2018","journal-title":"Plant Physiol. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1104\/pp.17.00652","article-title":"Spatial mapping and profiling of metabolite distributions during germination","volume":"174","author":"Feenstra","year":"2017","journal-title":"Plant Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1111\/jipb.13001","article-title":"The role of light in regulating seed dormancy and germination","volume":"62","author":"Yang","year":"2020","journal-title":"J. Integr. Plant Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.plaphy.2018.02.028","article-title":"Metabolomics analysis of \u2018Housui\u2019 Japanese pear flower buds during endodormancy reveals metabolic suppression by thermal fluctuation","volume":"126","author":"Horikoshi","year":"2018","journal-title":"Plant Physiol. Biochem."},{"key":"ref_53","unstructured":"Amarowicz, R., and Weidner, S. (2009). Grapevine Molecular Physiology & Biotechnology, Springer."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fpls.2013.00163","article-title":"Regulation of cell division and expansion by sugar and auxin signaling","volume":"4","author":"Wang","year":"2013","journal-title":"Front. Plant Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/s-2006-923797","article-title":"Crosstalk between auxin, cytokinins, and sugars in the plant cell cycle","volume":"8","author":"Hartig","year":"2006","journal-title":"Plant Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1093\/jxb\/erm121","article-title":"Glutamate in plants: Metabolism, regulation, and signalling","volume":"58","author":"Forde","year":"2007","journal-title":"J. Exp. Bot."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Li, W.-Y., Chen, B.-X., Chen, Z.-J., Gao, Y.-T., Chen, Z., and Liu, J. (2017). Reactive oxygen species generated by NADPH oxidases promote radicle protrusion and root elongation during rice seed germination. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010110"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.foodchem.2015.07.090","article-title":"The effects of GA and ABA treatments on metabolite profile of germinating barley","volume":"192","author":"Huang","year":"2016","journal-title":"Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Chen, C., Zeng, L., Zhao, H., and Ye, Q. (2020). Proteomic analysis of the early development of the Phalaenopsis amabilis flower bud under low temperature induction using the iTRAQ\/MRM approach. Molecules, 25.","DOI":"10.3390\/molecules25051244"},{"key":"ref_60","unstructured":"Tiburcio, A.F., and Alcazar, R. (2018). Polyamines: Methods in Molecular Biology, Humana Press."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cj.2017.08.007","article-title":"Cell signaling mechanisms and metabolic regulation of germination and dormancy in barley seeds","volume":"5","author":"Ma","year":"2017","journal-title":"Crop J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.molp.2015.09.005","article-title":"Amino acid catabolism in plants","volume":"8","author":"Hildebrandt","year":"2015","journal-title":"Mol. Plant"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"928","DOI":"10.3389\/fpls.2020.00928","article-title":"Connections between amino acid metabolisms in plants: Lysine as an example","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Hosseinifard, M., Stefaniak, S., Ghorbani Javid, M., Soltani, E., Wojtyla, \u0141., and Garnczarska, M. (2022). Contribution of exogenous proline to abiotic stresses tolerance in plants: A review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095186"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1105\/tpc.105.035659","article-title":"AREB1 is a transcription activator of novel ABRE-dependent ABA signaling that enhances drought stress tolerance in Arabidopsis","volume":"17","author":"Fujita","year":"2005","journal-title":"Plant Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/jxb\/ert457","article-title":"The sucrose\u2013trehalose 6-phosphate (Tre6P) nexus: Specificity and mechanisms of sucrose signalling by Tre6P","volume":"65","author":"Yadav","year":"2014","journal-title":"J. Exp. Bot."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1104\/pp.109.139204","article-title":"In vivo cell wall loosening by hydroxyl radicals during cress seed germination and elongation growth","volume":"150","author":"Muller","year":"2009","journal-title":"Plant Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1093\/jxb\/erv168","article-title":"Mannans and endo-\u03b2-mannanases (MAN) in Brachypodium distachyon: Expression profiling and possible role of the BdMAN genes during coleorhiza-limited seed germination","volume":"66","author":"Carbonero","year":"2015","journal-title":"J. Exp. Bot."},{"key":"ref_69","first-page":"577","article-title":"Transgenic canola and soybean seeds with increased lysine","volume":"13","author":"Falco","year":"1995","journal-title":"Bio\/technology"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Liu, X., Zhang, C., Wang, X., Liu, Q., Yuan, D., Pan, G., Sun, S.S., and Tu, J. (2016). Development of high-lysine rice via endosperm-specific expression of a foreign LYSINE RICH PROTEIN gene. BMC Plant Biol., 16.","DOI":"10.1186\/s12870-016-0837-x"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Jia, M., Wu, H., Clay, K.L., Jung, R., Larkins, B.A., and Gibbon, B.C. (2013). Identification and characterization of lysine-rich proteins and starch biosynthesis genes in the opaque2mutant by transcriptional and proteomic analysis. BMC Plant Biol., 13.","DOI":"10.1186\/1471-2229-13-60"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1002\/pmic.200700207","article-title":"Proteomic analysis of rice (Oryza sativa) seeds during germination","volume":"7","author":"Yang","year":"2007","journal-title":"Proteomics"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-313X.2005.02337.x","article-title":"Genome-wide profiling of stored mRNA in Arabidopsis thaliana seed germination: Epigenetic and genetic regulation of transcription in seed","volume":"41","author":"Nakabayashi","year":"2005","journal-title":"Plant J."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Gianinetti, A., Finocchiaro, F., Bagnaresi, P., Zechini, A., Faccioli, P., Cattivelli, L., Val\u00e8, G., and Biselli, C. (2018). Seed dormancy involves a transcriptional program that supports early plastid functionality during imbibition. Plants, 7.","DOI":"10.3390\/plants7020035"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1105\/tpc.17.00842","article-title":"Wheat miR9678 affects seed germination by generating phased siRNAs and modulating abscisic acid\/gibberellin signaling","volume":"30","author":"Guo","year":"2018","journal-title":"Plant Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"51","DOI":"10.6090\/jarq.40.51","article-title":"Involvement of polyamine in floral and fruit development","volume":"40","author":"Liu","year":"2006","journal-title":"Jpn. Agric. Res. Q. JARQ"},{"key":"ref_77","unstructured":"Paliyath, G., Murr, D.P., Handa, A.K., and Lurie, S. (2016). Postharvest Biology and Technology of Fruit, Vegetables and Flowers, Wiley-Blackwell."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Feduraev, P., Skrypnik, L., Riabova, A., Pungin, A., Tokupova, E., Maslennikov, P., and Chupakhina, G. (2020). Phenylalanine and tyrosine as exogenous precursors of wheat (Triticum aestivum L.) secondary metabolism through PAL-associated pathways. Plants, 9.","DOI":"10.3390\/plants9040476"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/treephys\/tpx109","article-title":"Phenylalanine as a nitrogen source induces root growth and nitrogen-use efficiency in Populus\u00d7 canescens","volume":"38","author":"Jiao","year":"2018","journal-title":"Tree Physiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"11625","DOI":"10.1038\/ncomms11625","article-title":"Alanine aminotransferase controls seed dormancy in barley","volume":"7","author":"Sato","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3389\/fpls.2017.01203","article-title":"Unraveling key metabolomic alterations in wheat embryos derived from freshly harvested and water-imbibed seeds of two wheat cultivars with contrasting dormancy status","volume":"8","author":"Das","year":"2017","journal-title":"Front. Plant Sci."},{"key":"ref_82","first-page":"e0140","article-title":"Proline Metabolism and Its Implications for Plant-Environment Interaction","volume":"8","author":"Verslues","year":"2010","journal-title":"Arab. Book\/Am. Soc. Plant Biol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Lechowska, K., Wojtyla, \u0141., Quinet, M., Kubala, S., Lutts, S., and Garnczarska, M. (2022). Endogenous Polyamines and Ethylene Biosynthesis in Relation to Germination of Osmoprimed Brassica napus Seeds under Salt Stress Katarzyna. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010349"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/treephys\/tpx133","article-title":"The role of arginine metabolic pathway during embryogenesis and germination in maritime pine (Pinus pinaster Ait.)","volume":"38","author":"Pascual","year":"2018","journal-title":"Tree Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1104\/pp.61.4.698","article-title":"Developmental biochemistry of cotton seed embryogenesis and germination: X. Nitrogen flow from arginine to asparagine in germination","volume":"61","author":"Dilworth","year":"1978","journal-title":"Plant Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1521-3803(20000101)44:1<23::AID-FOOD23>3.0.CO;2-B","article-title":"Changes in biogenic amines in mature and germinating legume seeds and their behavior during cooking","volume":"44","author":"Shalaby","year":"2000","journal-title":"Food\/Nahrung"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/nph.13090","article-title":"Seed production temperature regulation of primary dormancy occurs through control of seed coat phenylpropanoid metabolism","volume":"205","author":"MacGregor","year":"2014","journal-title":"New Phytol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"478","DOI":"10.21273\/JASHS.102.4.478","article-title":"Seed coat and water absorption properties of seed of near-isogenic snap bean lines differing in seed coat color","volume":"102","author":"Wyatt","year":"1977","journal-title":"J. Am. Soc. Hortic. Sci."},{"key":"ref_89","first-page":"45","article-title":"Germinability of leek seeds and its improvement by osmopriming","volume":"371","author":"Corbineau","year":"1993","journal-title":"Acta Hortic."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/jxb\/19.3.601","article-title":"MDormancy in seeds of Charlock: III. Occurrence and mode of action of an inhibitor associated with dormancy","volume":"19","author":"Edwards","year":"1968","journal-title":"J. Exp. Bot."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/jare.2000.0689","article-title":"Characteristics of seed germination in five non-halophytic Chinese desert shrub species","volume":"47","author":"Tobe","year":"2001","journal-title":"J. Arid. Environ."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e13656","DOI":"10.1111\/ppl.13656","article-title":"Sugars and the speed of life\u2014Metabolic signals that determine plant growth, development and death","volume":"174","author":"Wingler","year":"2022","journal-title":"Physiol. Plant."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Anderson, G.H., Veit, B., and Hanson, M.R. (2005). The Arabidopsis AtRaptor genes are essential for post-embryonic plant growth. BMC Biol., 3.","DOI":"10.1186\/1741-7007-3-12"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Tixier, A., Gambetta, G.A., Godfrey, J., Orozco, J., and Zwieniecki, M.A. (2019). Non-structural carbohydrates in dormant woody perennials; the tale of winter survival and spring arrival. Front. For. Glob. Chang., 2.","DOI":"10.3389\/ffgc.2019.00018"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3389\/fpls.2017.00788","article-title":"A conserved carbon starvation response underlies bud dormancy in woody and herbaceous species","volume":"8","author":"Tarancon","year":"2017","journal-title":"Front. Plant Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/treephys\/tpp028","article-title":"Sucrose phosphate synthase expression influences poplar phenology","volume":"29","author":"Park","year":"2009","journal-title":"Tree Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/j.1365-3040.2011.02346.x","article-title":"Quantitative trait loci analysis reveals a correlation between the ratio of sucrose\/raffinose family oligosaccharides and seed vigour in Medicago truncatula","volume":"34","author":"Vandecasteele","year":"2011","journal-title":"Plant Cell Environ."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/jipb.12690","article-title":"On the role of the tricarboxylic cid cycle in plant productivity","volume":"60","author":"Zhang","year":"2018","journal-title":"J. Integr. Plant Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pbi.2004.03.007","article-title":"Respiratory metabolism: Glycolysis, the TCA cycle and mitochondrial electron transport","volume":"7","author":"Fernie","year":"2004","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.phytochem.2009.04.023","article-title":"Jack of all trades or master of a few?","volume":"70","author":"Fernie","year":"2009","journal-title":"Phytochemistry"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Kim, H.U. (2020). Lipid metabolism in plants. Plants, 9.","DOI":"10.3390\/plants9070871"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.3389\/fpls.2019.01743","article-title":"Signaling Role of Glutamate in Plants","volume":"10","author":"Qiu","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/jxb\/err313","article-title":"In Posidonia oceanica cadmium induces changes in DNA methylation and chromatin patterning","volume":"63","author":"Greco","year":"2012","journal-title":"J. Exp. Bot."},{"key":"ref_104","unstructured":"Nieuwland, J., Menges, M., and Murray, J.A. (2007). Cell Cycle Control and Plant Development, Blackwell Publishing."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.plaphy.2011.04.013","article-title":"Plant Physiology and Biochemistry Enhanced activity of galactono-1, 4-lactone dehydrogenase and ascorbate e glutathione cycle in mitochondria from complex III deficient Arabidopsis","volume":"49","author":"Zsigmond","year":"2011","journal-title":"Plant Physiol. Biochem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1399-3054.2009.01340.x","article-title":"Reactive oxygen species and nitric oxide in plant mitochondria: Origin and redundant regulatory systems","volume":"138","author":"Blokhina","year":"2010","journal-title":"Physiol. Plant."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1111\/j.1438-8677.2011.00543.x","article-title":"Galactone-\u03b3-lactone-dependent ascorbate biosynthesis alters wheat kernel maturation","volume":"14","author":"Paradiso","year":"2012","journal-title":"Plant Biol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Xool-Tamayo, J., Tamayo-Ordo\u00f1ez, Y., Monforte-Gonz\u00e1lez, M., Mu\u00f1oz-S\u00e1nchez, J.A., and V\u00e1zquez-Flota, F. (2021). Alkaloid Biosynthesis in the Early Stages of the Germination of Argemone mexicana L. (Papaveraceae). Plants, 10.","DOI":"10.3390\/plants10102226"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Shah, A., and Smith, D.L. (2020). Flavonoids in agriculture: Chemistry and roles in, biotic and abiotic stress responses, and microbial associations. Agronomy, 10.","DOI":"10.3390\/agronomy10081209"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/nph.14178","article-title":"Why do plants produce so many terpenoid compounds?","volume":"220","author":"Pichersky","year":"2018","journal-title":"New Phytol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"16240","DOI":"10.3390\/molecules191016240","article-title":"Flavonoids as Important Molecules of Plant Interactions with the Environment","volume":"19","author":"Mierziak","year":"2014","journal-title":"Molecules"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"110471","DOI":"10.1016\/j.plantsci.2020.110471","article-title":"Specialized phenolic compounds in seeds: Structures, functions, and regulations","volume":"296","author":"Corso","year":"2020","journal-title":"Plant Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/10408690390826464","article-title":"Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions","volume":"43","author":"Higdon","year":"2003","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1006\/abbi.1999.1525","article-title":"Modulation of liposomal membrane fluidity by flavonoids and isoflavonoids","volume":"373","author":"Arora","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0891-5849(95)02014-4","article-title":"Antioxidant properties of hydroxy-flavones","volume":"20","author":"Cotelle","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Araniti, F., and Prinsi, B. (2022). Seed Germination Induced by Coumarin Is Mediated by a Lower Ability to Sustain the Energetic Metabolism. Plants, 11.","DOI":"10.3390\/plants11070843"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Chattha, F.A., Munawar, M.A., Nisa, M., and Kousar, S. (2016). Coumarin-Based Heteroaromatics as Plant Growth Regulators, University of the Punjab.","DOI":"10.5772\/64854"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.foodchem.2019.02.131","article-title":"Effects of exogenous Ca2+ on phenolic accumulation and physiological changes in germinated wheat (Triticum aestivum L.) under UV-B radiation","volume":"288","author":"Chen","year":"2019","journal-title":"Food Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10886-008-9449-8","article-title":"Bidens pilosa L. exhibits high sensitivity to coumarin in comparison with three other weed species","volume":"34","author":"Pergo","year":"2008","journal-title":"J. Chem. Ecol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0031-9422(00)88228-X","article-title":"Studies on lettuce seed germination-I. Coumarin induced dormancy","volume":"7","author":"Berrie","year":"1968","journal-title":"Phytochemistry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1104\/pp.47.2.312","article-title":"Effect of seselin and coumarin on growth, indoleacetic acid oxidase and peroxidase with special reference to cucumber radicles","volume":"47","author":"Goren","year":"1971","journal-title":"Plant Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Sharma, A., Shahzad, B., Rehman, A., Bhardwaj, R., and Landi, M. (2019). Response of Phenylpropanoid Pathway and the Role of Polyphenols in Plants under Abiotic Stress. Molecules, 24.","DOI":"10.3390\/molecules24132452"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Ninkuu, V., Zhang, L., Yan, J., Fu, Z., Yang, T., and Zeng, H. (2021). Biochemistry of Terpenes and Recent Advances in Plant Protection. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115710"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Das, A.K., Anik, T.R., Rahman, M.M., Keya, S.S., Islam, M.R., Rahman, M.A., Sultana, S., Ghosh, P.K., Khan, S., and Ahamed, T. (2022). Ethanol Treatment Enhances Physiological and Biochemical Responses to Mitigate Saline Toxicity in Soybean. Plants, 11.","DOI":"10.3390\/plants11030272"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"16669","DOI":"10.1038\/s41598-020-73704-x","article-title":"Arabidopsis phenotyping reveals the importance of alcohol dehydrogenase and pyruvate decarboxylase for aerobic plant growth","volume":"10","author":"Ventura","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Su, W., Ren, Y., Wang, D., Su, Y., Feng, J., Zhang, C., Tang, H., Xu, L., Muhammad, K., and Que, Y. (2020). The alcohol dehydrogenase gene family in sugarcane and its involvement in cold stress regulation. BMC Genom., 21.","DOI":"10.1186\/s12864-020-06929-9"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/tpj.14285","article-title":"Multifaceted activity of cytokinin in leaf development shapes its size and structure in Arabidopsis","volume":"97","author":"Vercruyssen","year":"2019","journal-title":"Plant J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00425-017-2712-x","article-title":"Different exogenous sugars affect the hormone signal pathway and sugar metabolism in \u201cRed Globe\u201d (Vitis vinifera L.) plantlets grown in vitro as shown by transcriptomic analysis","volume":"246","author":"Mao","year":"2017","journal-title":"Planta"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1073\/pnas.1215788110","article-title":"CYP714B1 and CYP714B2 encode gibberellin 13-oxidases that reduce gibberellin activity in rice","volume":"110","author":"Magome","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3389\/fpls.2019.00921","article-title":"The synthesis and role of \u03b2-alanine in plants","volume":"10","author":"Parthasarathy","year":"2019","journal-title":"Front. Plant Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00726-010-0596-1","article-title":"Analysis of alanine aminotransferase in various organs of soybean (Glycine max) and in dependence of different nitrogen fertilisers during hypoxic stress","volume":"39","author":"Rocha","year":"2010","journal-title":"Amino Acids"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12374-018-0288-z","article-title":"FLOURY ENDOSPERM12 encoding alanine aminotransferase 1 regulates carbon and nitrogen metabolism in rice","volume":"62","author":"Zhong","year":"2019","journal-title":"J. Plant Biol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1365-313X.2009.03945.x","article-title":"Expression of a bacterial bi-functional chorismate mutase\/prephenate dehydratase modulates primary and secondary metabolism associated with aromatic amino acids in Arabidopsis","volume":"60","author":"Tzin","year":"2009","journal-title":"Plant J."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.copbio.2019.02.018","article-title":"Lignin biosynthesis and its integration into metabolism","volume":"56","author":"Vanholme","year":"2019","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.phytochem.2018.02.003","article-title":"Tyrosine biosynthesis, metabolism, and catabolism in plants","volume":"149","author":"Schenck","year":"2018","journal-title":"Phytochemistry"},{"key":"ref_136","unstructured":"Dennis, R. (2019). The Role of Primary Carbohydrate Metabolism in Wheat Grain Dormancy and Germination. [Ph.D. Thesis, The Australian National University]."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/13\/5\/610\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:25:53Z","timestamp":1760124353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/13\/5\/610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,28]]},"references-count":136,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["metabo13050610"],"URL":"https:\/\/doi.org\/10.3390\/metabo13050610","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,28]]}}}