{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:37:06Z","timestamp":1788863826174,"version":"build-2803163510"},"reference-count":106,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 142298"],"award-info":[{"award-number":["MOP 142298"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["RGPIN-5457-2017"],"award-info":[{"award-number":["RGPIN-5457-2017"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science and Engineering Research Council","award":["MOP 142298"],"award-info":[{"award-number":["MOP 142298"]}]},{"name":"Natural Science and Engineering Research Council","award":["RGPIN-5457-2017"],"award-info":[{"award-number":["RGPIN-5457-2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Physical activity (PA) and exercise have been associated with a reduced risk of cancer, obesity, and diabetes. In the context of pregnancy, maintaining an active lifestyle has been shown to decrease gestational weight gain (GWG) and lower the risk of gestational diabetes mellitus (GDM), hypertension, and macrosomia in offspring. The main pathways activated by PA include BCAAs, lipids, and bile acid metabolism, thereby improving insulin resistance in pregnant individuals. Despite these known benefits, the underlying metabolites and biological mechanisms affected by PA remain poorly understood, highlighting the need for further investigation. Metabolomics, a comprehensive study of metabolite classes, offers valuable insights into the widespread metabolic changes induced by PA. This narrative review focuses on PA metabolomics research using different analytical platforms to analyze pregnant individuals. Existing studies support the hypothesis that exercise behaviour can influence the metabolism of different populations, including pregnant individuals and their offspring. While PA has shown considerable promise in maintaining metabolic health in non-pregnant populations, our comprehension of metabolic changes in the context of a healthy pregnancy remains limited. As a result, further investigation is necessary to clarify the metabolic impact of PA within this unique group, often excluded from physiological research.<\/jats:p>","DOI":"10.3390\/metabo13121178","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T12:01:00Z","timestamp":1701259260000},"page":"1178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Metabolomics to Understand Alterations Induced by Physical Activity during Pregnancy"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9456-7056","authenticated-orcid":false,"given":"Ana Carolina Rosa","family":"da Silva","sequence":"first","affiliation":[{"name":"School of Human Kinetics, Faculty of Health Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Yadegari","sequence":"additional","affiliation":[{"name":"School of Human Kinetics, Faculty of Health Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velislava","family":"Tzaneva","sequence":"additional","affiliation":[{"name":"School of Human Kinetics, Faculty of Health Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarushika","family":"Vasanthan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, ON M5G 2A7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Laketic","sequence":"additional","affiliation":[{"name":"Alberta Children\u2019s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1224-979X","authenticated-orcid":false,"given":"Jane","family":"Shearer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Kinesiology, Cumming School of Medicine and Alberta Children\u2019s Hospital Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8947-8152","authenticated-orcid":false,"given":"Shannon A.","family":"Bainbridge","sequence":"additional","affiliation":[{"name":"Interdisciplinary School of Health Sciences, Faculty of Health Sciences, Ottawa, ON K1N 6N5, Canada"},{"name":"Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0657-1838","authenticated-orcid":false,"given":"Cory","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi B.","family":"Adamo","sequence":"additional","affiliation":[{"name":"School of Human Kinetics, Faculty of Health Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/aje\/kwz171","article-title":"Metabolome-Wide Association Study of the Relationship Between Habitual Physical Activity and Plasma Metabolite Levels","volume":"188","author":"Ding","year":"2019","journal-title":"Am. 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