{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:51:08Z","timestamp":1793829068257,"version":"4.6.1"},"reference-count":139,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720230084"],"award-info":[{"award-number":["20720230084"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Gestational diabetes mellitus (GDM) is a complex metabolic condition during pregnancy with an intricate link to gut microbiota alterations. Throughout gestation, notable shifts in the gut microbial component occur. GDM is marked by significant dysbiosis, with a decline in beneficial taxa like Bifidobacterium and Lactobacillus and a surge in opportunistic taxa such as Enterococcus. These changes, detectable in the first trimester, hint as the potential early markers for GDM risk. Alongside these taxa shifts, microbial metabolic outputs, especially short-chain fatty acids and bile acids, are perturbed in GDM. These metabolites play pivotal roles in host glucose regulation, insulin responsiveness, and inflammation modulation, which are the key pathways disrupted in GDM. Moreover, maternal GDM status influences neonatal gut microbiota, indicating potential intergenerational health implications. With the advance of multi-omics approaches, a deeper understanding of the nuanced microbiota\u2013host interactions via metabolites in GDM is emerging. The reviewed knowledge offers avenues for targeted microbiota-based interventions, holding promise for innovative strategies in GDM diagnosis, management, and prevention.<\/jats:p>","DOI":"10.3390\/metabo14010043","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T09:39:57Z","timestamp":1704879597000},"page":"43","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Interaction and Metabolic Pathways: Elucidating the Role of Gut Microbiota in Gestational Diabetes Mellitus Pathogenesis"],"prefix":"10.3390","volume":"14","author":[{"given":"Lindong","family":"Mao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Infectious Disease Vaccine Development, Xiang An Biomedicine Laboratory & State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biling","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Vaccine Development, Xiang An Biomedicine Laboratory & State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Vaccine Development, Xiang An Biomedicine Laboratory & State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-4919","authenticated-orcid":false,"given":"Heqing","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Infectious Disease Vaccine Development, Xiang An Biomedicine Laboratory & State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, China"},{"name":"Department of Obstetrics, Women and Children\u2019s Hospital, School of Medicine, Xiamen University, Xiamen 361003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1172\/JCI200524531","article-title":"Gestational diabetes mellitus","volume":"115","author":"Buchanan","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-019-0098-8","article-title":"Gestational diabetes mellitus","volume":"5","author":"McIntyre","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1001\/jama.2018.11628","article-title":"Association of Gestational Diabetes With Maternal Disorders of Glucose Metabolism and Childhood Adiposity","volume":"320","author":"Lowe","year":"2018","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021","volume":"402","author":"Ong","year":"2023","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1007\/s00125-017-4206-6","article-title":"Gestational diabetes and adverse perinatal outcomes from 716,152 births in France in 2012","volume":"60","author":"Billionnet","year":"2017","journal-title":"Diabetologia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/obr.12645","article-title":"Long-term risk of diabetes in women at varying durations after gestational diabetes: A systematic review and meta-analysis with more than 2 million women","volume":"19","author":"Song","year":"2018","journal-title":"Obes. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41588-019-0350-x","article-title":"Causal Relationships among the Gut Microbiome, Short-Chain Fatty Acids and Metabolic Diseases","volume":"51","author":"Sanna","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature18309","article-title":"Acetate Mediates a Microbiome-Brain-\u03b2-Cell Axis to Promote Metabolic Syndrome","volume":"534","author":"Perry","year":"2016","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","article-title":"Bile Acid\u2013Microbiota Crosstalk in Gastrointestinal Inflammation and Carcinogenesis","volume":"15","author":"Jia","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048","article-title":"Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling","volume":"163","author":"Levy","year":"2015","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/gutjnl-2022-328406","article-title":"Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis","volume":"72","author":"Pinto","year":"2023","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","article-title":"Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases","volume":"569","author":"Arze","year":"2019","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1038\/s41598-019-40182-9","article-title":"Effects of bowel preparation on the human gut microbiome and metabolome","volume":"9","author":"Nagata","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1038\/s41598-017-02546-x","article-title":"Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight\/obese men: A randomized crossover trial","volume":"7","author":"Canfora","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1093\/bioinformatics\/bty941","article-title":"The Microbiome Modeling Toolbox: From microbial interactions to personalized microbial communities","volume":"35","author":"Baldini","year":"2019","journal-title":"Bioinformatics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-Gut Microbiota Metabolic Interactions","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00253-016-8006-6","article-title":"Interaction of gut microbiota with bile acid metabolism and its influence on disease states","volume":"101","author":"Staley","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/aji.12289","article-title":"Understanding the complexity of the immune system during pregnancy","volume":"72","author":"Racicot","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.2337\/dc22-2226","article-title":"Distinct Insulin Physiology Trajectories in Euglycemic Pregnancy and Gestational Diabetes Mellitus","volume":"46","author":"Thaweethai","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"13212","DOI":"10.1038\/srep13212","article-title":"The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes","volume":"5","author":"Fugmann","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2012.07.008","article-title":"Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy","volume":"150","author":"Koren","year":"2012","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101805","DOI":"10.1016\/j.molmet.2023.101805","article-title":"Effects of metformin on the gut microbiota: A systematic review","volume":"77","author":"Pavlo","year":"2023","journal-title":"Mol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Molina-Vega, M., Pic\u00f3n-C\u00e9sar, M.J., Guti\u00e9rrez-Repiso, C., Fern\u00e1ndez-Valero, A., Lima-Rubio, F., Gonz\u00e1lez-Romero, S., Moreno-Indias, I., and Tinahones, F.J. (2022). Metformin Action over Gut Microbiota Is Related to Weight and Glycemic Control in Gestational Diabetes Mellitus: A Randomized Trial. Biomed. Pharmacother., 145.","DOI":"10.1016\/j.biopha.2021.112465"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice","volume":"63","author":"Shin","year":"2014","journal-title":"Gut"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Tocci, V., Mirabelli, M., Salatino, A., Sicilia, L., Giuliano, S., Brunetti, F.S., Chiefari, E., De Sarro, G., Foti, D.P., and Brunetti, A. (2023). Metformin in Gestational Diabetes Mellitus: To Use or Not to Use, That Is the Question. Pharmaceuticals, 16.","DOI":"10.3390\/ph16091318"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrmicro2297","article-title":"Host interactions of probiotic bacterial surface molecules: Comparison with commensals and pathogens","volume":"8","author":"Lebeer","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"O\u2019Callaghan, A., and van Sinderen, D. (2016). Bifidobacteria and Their Role as Members of the Human Gut Microbiota. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00925"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nri.2017.7","article-title":"Dysbiosis and the immune system","volume":"17","author":"Levy","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nature20557","article-title":"Microcins mediate competition among Enterobacteriaceae in the inflamed gut","volume":"540","author":"Nuccio","year":"2016","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.2337\/db16-0278","article-title":"Connections Between the Gut Microbiome and Metabolic Hormones in Early Pregnancy in Overweight and Obese Women","volume":"65","author":"Barrett","year":"2016","journal-title":"Diabetes"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e4128","DOI":"10.1210\/clinem\/dgab346","article-title":"Association of Gut Microbiota during Early Pregnancy with Risk of Incident Gestational Diabetes Mellitus","volume":"106","author":"Hu","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ma, S., You, Y., Huang, L., Long, S., Zhang, J., Guo, C., Zhang, N., Wu, X., Xiao, Y., and Tan, H. (2020). Alterations in Gut Microbiota of Gestational Diabetes Patients During the First Trimester of Pregnancy. Front. Cell Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00058"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s00592-017-1056-0","article-title":"Gut Microbiota Aberrations Precede Diagnosis of Gestational Diabetes Mellitus","volume":"54","author":"Mokkala","year":"2017","journal-title":"Acta Diabetol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gigascience\/gix058","article-title":"Connections between the human gut microbiome and gestational diabetes mellitus","volume":"6","author":"Kuang","year":"2017","journal-title":"GigaScience"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"861","DOI":"10.4239\/wjd.v13.i10.861","article-title":"Correlation between gut microbiota and glucagon-like peptide-1 in patients with gestational diabetes mellitus","volume":"13","author":"Liang","year":"2022","journal-title":"World J. Diabetes"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s40618-021-01595-4","article-title":"16S rRNA gene amplicon sequencing of gut microbiota in gestational diabetes mellitus and their correlation with disease risk factors","volume":"45","author":"Wei","year":"2022","journal-title":"J. Endocrinol. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1840765","DOI":"10.1080\/19490976.2020.1840765","article-title":"Altered gut bacterial and metabolic signatures and their interaction in gestational diabetes mellitus","volume":"12","author":"Wang","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6081248","DOI":"10.1155\/2019\/6081248","article-title":"The Gut Microbiota in Women Suffering from Gestational Diabetes Mellitus with the Failure of Glycemic Control by Lifestyle Modification","volume":"2019","author":"Ye","year":"2019","journal-title":"J. Diabetes Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12967-021-03040-9","article-title":"Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population","volume":"19","author":"Su","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e008342","DOI":"10.1161\/JAHA.117.008342","article-title":"Effect of Vegan Fecal Microbiota Transplantation on Carnitine- and Choline-Derived Trimethylamine-N-Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome","volume":"7","author":"Smits","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_42","first-page":"560","article-title":"Gut bacteria in health and disease","volume":"9","author":"Quigley","year":"2013","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Org, E., Blum, Y., Kasela, S., Mehrabian, M., Kuusisto, J., Kangas, A.J., Soininen, P., Wang, Z., Ala-Korpela, M., and Hazen, S.L. (2017). Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort. Genome Biol., 18.","DOI":"10.1186\/s13059-017-1194-2"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.chom.2018.06.005","article-title":"Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome","volume":"24","author":"Ferretti","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"12216","DOI":"10.1038\/s41598-018-30735-9","article-title":"Changes in the gut microbiota composition during pregnancy in patients with gestational diabetes mellitus (GDM)","volume":"8","author":"Ferrocino","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Crusell, M.K.W., Hansen, T.H., Nielsen, T., Allin, K.H., R\u00fchlemann, M.C., Damm, P., Vestergaard, H., R\u00f8rbye, C., J\u00f8rgensen, N.R., and Christiansen, O.B. (2018). Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum. Microbiome, 6.","DOI":"10.1186\/s40168-018-0472-x"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1007\/s00125-018-4550-1","article-title":"Aberrant intestinal microbiota in individuals with prediabetes","volume":"61","author":"Allin","year":"2018","journal-title":"Diabetologia"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Chen, T., Qin, Y., Chen, M., Zhang, Y., Wang, X., Dong, T., Chen, G., Sun, X., Lu, T., and White, R.A. (2021). Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome. BMC Med., 19.","DOI":"10.1186\/s12916-021-01991-w"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e0046522","DOI":"10.1128\/msystems.00465-22","article-title":"Role of the Gut Microbiota in the Increased Infant Body Mass Index Induced by Gestational Diabetes Mellitus","volume":"7","author":"Zhu","year":"2022","journal-title":"mSystems"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Crusell, M.K.W., Hansen, T.H., Nielsen, T., Allin, K.H., R\u00fchlemann, M.C., Damm, P., Vestergaard, H., R\u00f8rbye, C., J\u00f8rgensen, N.R., and Christiansen, O.B. (2020). Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.536282"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9994734","DOI":"10.1155\/2021\/9994734","article-title":"Microbiome and Gestational Diabetes: Interactions with Pregnancy Outcome and Long-Term Infant Health","volume":"2021","author":"Neri","year":"2021","journal-title":"J. Diabetes Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Ponzo, V., Ferrocino, I., Zarovska, A., Amenta, M.B., Leone, F., Monzeglio, C., Rosato, R., Pellegrini, M., Gambino, R., and Cassader, M. (2019). The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM). PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0226545"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1136\/gutjnl-2018-315988","article-title":"Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus","volume":"67","author":"Wang","year":"2018","journal-title":"Gut"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hu, J., Nomura, Y., Bashir, A., Fernandez-Hernandez, H., Itzkowitz, S., Pei, Z., Stone, J., Loudon, H., and Peter, I. (2013). Diversified microbiota of meconium is affected by maternal diabetes status. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078257"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Li, X., Yu, D., Wang, Y., Yuan, H., Ning, X., Rui, B., Lei, Z., Yuan, J., Yan, J., and Li, M. (2021). The Intestinal Dysbiosis of Mothers with Gestational Diabetes Mellitus (GDM) and Its Impact on the Gut Microbiota of Their Newborns. Can. J. Infect. Dis. Med. Microbiol., 2021.","DOI":"10.1155\/2021\/3044534"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.3945\/jn.113.178772","article-title":"The human milk metabolome reveals diverse oligosaccharide profiles","volume":"143","author":"Smilowitz","year":"2013","journal-title":"J. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Sundekilde, U.K., Downey, E., O\u2019Mahony, J.A., O\u2019Shea, C.A., Ryan, C.A., Kelly, A.L., and Bertram, H.C. (2016). The Effect of Gestational and Lactational Age on the Human Milk Metabolome. Nutrients, 8.","DOI":"10.3390\/nu8050304"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Yefet, E., Bar, L., Izhaki, I., Iskander, R., Massalha, M., Younis, J.S., and Nachum, Z. (2023). Effects of Probiotics on Glycemic Control and Metabolic Parameters in Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis. Nutrients, 15.","DOI":"10.3390\/nu15071633"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Pammi, M., Cope, J., Tarr, P.I., Warner, B.B., Morrow, A.L., Mai, V., Gregory, K.E., Kroll, J.S., McMurtry, V., and Ferris, M.J. (2017). Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: A systematic review and meta-analysis. Microbiome, 5.","DOI":"10.1186\/s40168-017-0248-8"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Sordillo, J.E., Zhou, Y., McGeachie, M.J., Ziniti, J., Lange, N., Laranjo, N., Savage, J.R., Carey, V., O\u2019Connor, G., and Sandel, M. (2017). Factors influencing the infant gut microbiome at age 3\u20136 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART). J. Allergy Clin. Immunol., 139.","DOI":"10.1016\/j.jaci.2016.08.045"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e2205289","DOI":"10.1002\/advs.202205289","article-title":"The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case-Control Study of Gestational Diabetes Mellitus","volume":"10","author":"Sun","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"R\u00edos-Covi\u00e1n, D., Ruas-Madiedo, P., Margolles, A., Gueimonde, M., de Los Reyes-Gavil\u00e1n, C.G., and Salazar, N. (2016). Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00185"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Lin, H.V., Frassetto, A., Kowalik, E.J., Nawrocki, A.R., Lu, M.M., Kosinski, J.R., Hubert, J.A., Szeto, D., Yao, X., and Forrest, G. (2012). Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035240"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1073\/pnas.1323599111","article-title":"Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut","volume":"111","author":"Joyce","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.copbio.2012.08.005","article-title":"Bacteria as vitamin suppliers to their host: A gut microbiota perspective","volume":"24","author":"LeBlanc","year":"2013","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"He, J., Zhang, P., Shen, L., Niu, L., Tan, Y., Chen, L., Zhao, Y., Bai, L., Hao, X., and Li, X. (2020). Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176356"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4161\/gmic.24707","article-title":"Holobiont nutrition: Considering the role of the gastrointestinal microbiota in the health benefits of whole grains","volume":"4","author":"Walter","year":"2013","journal-title":"Gut Microbes"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nm.3779","article-title":"Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes","volume":"21","author":"Tang","year":"2015","journal-title":"Nat. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1530\/JME-20-0094","article-title":"Short-chain fatty acids as novel therapeutics for gestational diabetes","volume":"65","author":"Roy","year":"2020","journal-title":"J. Mol. Endocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Zi\u0119tek, M., Celewicz, Z., and Szczuko, M. (2021). Short-Chain Fatty Acids, Maternal Microbiota and Metabolism in Pregnancy. Nutrients, 13.","DOI":"10.3390\/nu13041244"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.trsl.2012.10.007","article-title":"Short chain fatty acids and their receptors: New metabolic targets","volume":"161","author":"Layden","year":"2013","journal-title":"Transl. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1463-1326.2009.01114.x","article-title":"Lipid receptors and islet function: Therapeutic implications?","volume":"11","author":"Kebede","year":"2009","journal-title":"Diabetes Obes. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Wang, S., Liu, Y., Qin, S., and Yang, H. (2022). Composition of Maternal Circulating Short-Chain Fatty Acids in Gestational Diabetes Mellitus and Their Associations with Placental Metabolism. Nutrients, 14.","DOI":"10.3390\/nu14183727"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s40618-020-01196-7","article-title":"A higher level of total bile acid in early mid-pregnancy is associated with an increased risk of gestational diabetes mellitus: A prospective cohort study in Wuhan, China","volume":"43","author":"Kong","year":"2020","journal-title":"J. Endocrinol. Investig."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ebiom.2018.08.015","article-title":"Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control study","volume":"35","author":"Li","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/cphy.c120023","article-title":"Bile acid metabolism and signaling","volume":"3","author":"Chiang","year":"2013","journal-title":"Compr. Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1152\/physrev.00010.2008","article-title":"Role of bile acids and bile acid receptors in metabolic regulation","volume":"89","author":"Lefebvre","year":"2009","journal-title":"Physiol. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/19490976.2015.1127483","article-title":"Consequences of bile salt biotransformations by intestinal bacteria","volume":"7","author":"Ridlon","year":"2016","journal-title":"Gut Microbes"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism","volume":"24","author":"Sayin","year":"2016","journal-title":"Cell Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"669","DOI":"10.4161\/19490976.2014.969986","article-title":"Bacterial bile salt hydrolase in host metabolism: Potential for influencing gastrointestinal microbe-host crosstalk","volume":"5","author":"Joyce","year":"2014","journal-title":"Gut Microbes"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3233\/NHA-150002","article-title":"Human gut microbiota and healthy aging: Recent developments and future prospective","volume":"4","author":"Kumar","year":"2016","journal-title":"Nutr. Healthy Aging"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1099\/ijsem.0.004107","article-title":"A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae","volume":"70","author":"Zheng","year":"2020","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1099\/00207713-50-4-1595","article-title":"Catenibacterium mitsuokai gen. nov., sp. nov., a gram-positive anaerobic bacterium isolated from human faeces","volume":"50","author":"Kageyama","year":"2000","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature12347","article-title":"Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome","volume":"499","author":"Yoshimoto","year":"2013","journal-title":"Nature"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"26745","DOI":"10.1038\/srep26745","article-title":"Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans","volume":"6","author":"Randrianarisoa","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1055\/s-0035-1569330","article-title":"Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels","volume":"124","author":"Dambrova","year":"2016","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1600324","DOI":"10.1002\/mnfr.201600324","article-title":"Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial","volume":"61","author":"Cho","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e004947","DOI":"10.1161\/JAHA.116.004947","article-title":"Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta-Analysis of Prospective Studies","volume":"6","author":"Heianza","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1093\/eurheartj\/ehx342","article-title":"Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: A systematic review and dose-response meta-analysis","volume":"38","author":"Schiattarella","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_96","first-page":"320","article-title":"Formation of methylamines from ingested choline and lecithin","volume":"225","author":"Zeisel","year":"1983","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0278-6915(99)00028-9","article-title":"Dietary precursors of trimethylamine in man: A pilot study","volume":"37","author":"Zhang","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbrc.2016.11.017","article-title":"Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome","volume":"481","author":"Sun","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e002767","DOI":"10.1161\/JAHA.115.002767","article-title":"Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-\u03baB","volume":"5","author":"Seldin","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5627","DOI":"10.1210\/jc.2003-032097","article-title":"Release of proinflammatory cytokines and 8-isoprostane from placenta, adipose tissue, and skeletal muscle from normal pregnant women and women with gestational diabetes mellitus","volume":"89","author":"Lappas","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2006.02.004","article-title":"Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents","volume":"3","author":"Overton","year":"2006","journal-title":"Cell Metab."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1677\/JOE-08-0453","article-title":"GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis","volume":"201","author":"Lan","year":"2009","journal-title":"J. Endocrinol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/2040-2392-4-42","article-title":"Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder","volume":"4","author":"Wang","year":"2013","journal-title":"Mol. Autism"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1073\/pnas.1115621109","article-title":"Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection","volume":"109","author":"Fanning","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"16831","DOI":"10.1038\/srep16831","article-title":"Intestinal organoids for assessing nutrient transport, sensing and incretin secretion","volume":"5","author":"Zietek","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1038\/ncomms6492","article-title":"Prediction and quantification of bioactive microbiota metabolites in the mouse gut","volume":"5","author":"Sridharan","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Janeiro, M.H., Ram\u00edrez, M.J., Milagro, F.I., Mart\u00ednez, J.A., and Solas, M. (2018). Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target. Nutrients, 10.","DOI":"10.3390\/nu10101398"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2337\/db21-1093","article-title":"Predictive Metabolomic Markers in Early to Mid-pregnancy for Gestational Diabetes Mellitus: A Prospective Test and Validation Study","volume":"71","author":"Zhu","year":"2022","journal-title":"Diabetes"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature24661","article-title":"A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites","volume":"551","author":"Dodd","year":"2017","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.celrep.2018.03.109","article-title":"Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages","volume":"23","author":"Krishnan","year":"2018","journal-title":"Cell Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1186\/s13063-016-1617-5","article-title":"Effects of probiotics (Vivomixx\u00ae) in obese pregnant women and their newborn: Study protocol for a randomized controlled trial","volume":"17","author":"Halkjaer","year":"2016","journal-title":"Trials"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.3945\/ajcn.113.079723","article-title":"Probiotics in obese pregnancy do not reduce maternal fasting glucose: A double-blind, placebo-controlled, randomized trial (Probiotics in Pregnancy Study)","volume":"99","author":"Lindsay","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1017\/S0007114509993898","article-title":"Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: A double-blind, placebo-controlled study","volume":"103","author":"Luoto","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1017\/S0007114517000289","article-title":"Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: A randomised controlled trial","volume":"117","author":"Wickens","year":"2017","journal-title":"Br. J. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3920\/BM2012.0065","article-title":"Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: Novel insights into molecular targets and interventions using prebiotics","volume":"5","author":"Geurts","year":"2014","journal-title":"Benef. Microbes"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Taylor, B.L., Woodfall, G.E., Sheedy, K.E., O\u2019Riley, M.L., Rainbow, K.A., Bramwell, E.L., and Kellow, N.J. (2017). Effect of Probiotics on Metabolic Outcomes in Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 9.","DOI":"10.3390\/nu9050461"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.diabet.2016.04.009","article-title":"Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: A randomized, double-blind, placebo-controlled trial","volume":"42","author":"Karamali","year":"2016","journal-title":"Diabetes Metab."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Lindsay, K.L., Brennan, L., Kennelly, M.A., Maguire, O.C., Smith, T., Curran, S., Coffey, M., Foley, M.E., Hatunic, M., and Shanahan, F. (2015). Impact of probiotics in women with gestational diabetes mellitus on metabolic health: A randomized controlled trial. Am. J. Obstet. Gynecol., 212.","DOI":"10.1016\/j.ajog.2014.10.078"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/dc18-2248","article-title":"Probiotics for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Women: Findings From the SPRING Double-Blind Randomized Controlled Trial","volume":"42","author":"Callaway","year":"2019","journal-title":"Diabetes Care"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Hasain, Z., Raja Ali, R.A., Ahmad, H.F., Abdul Rauf, U.F., Oon, S.F., and Mokhtar, N.M. (2022). The Roles of Probiotics in the Gut Microbiota Composition and Metabolic Outcomes in Asymptomatic Post-Gestational Diabetes Women: A Randomized Controlled Trial. Nutrients, 14.","DOI":"10.3390\/nu14183878"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.diabres.2018.02.008","article-title":"The effects of synbiotic supplementation on insulin resistance\/sensitivity, lipid profile and total antioxidant capacity in women with gestational diabetes mellitus: A randomized double blind placebo controlled clinical trial","volume":"138","author":"Nabhani","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1079\/NRR200479","article-title":"Dietary modulation of the human colonic microbiota: Updating the concept of prebiotics","volume":"17","author":"Gibson","year":"2004","journal-title":"Nutr. Res. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"830s","DOI":"10.1093\/jn\/137.3.830S","article-title":"Prebiotics: The concept revisited","volume":"137","author":"Roberfroid","year":"2007","journal-title":"J. Nutr."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3390\/nu5041417","article-title":"Fiber and prebiotics: Mechanisms and health benefits","volume":"5","author":"Slavin","year":"2013","journal-title":"Nutrients"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","article-title":"The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics","volume":"18","author":"Salminen","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1017\/S0007114513003607","article-title":"Metabolic benefits of dietary prebiotics in human subjects: A systematic review of randomised controlled trials","volume":"111","author":"Kellow","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114510003363","article-title":"Prebiotic effects: Metabolic and health benefits","volume":"104","author":"Roberfroid","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrendo.2015.128","article-title":"Short-chain fatty acids in control of body weight and insulin sensitivity","volume":"11","author":"Canfora","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.2337\/db11-0227","article-title":"Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice","volume":"60","author":"Everard","year":"2011","journal-title":"Diabetes"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jhep.2013.01.003","article-title":"Modulation of the fecal bile acid profile by gut microbiota in cirrhosis","volume":"58","author":"Kakiyama","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1210\/en.2015-1321","article-title":"Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors","volume":"156","author":"Brighton","year":"2015","journal-title":"Endocrinology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.bbrc.2012.09.104","article-title":"Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic \u03b2 cells","volume":"427","author":"Kumar","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3748\/wjg.15.804","article-title":"Bile acids: Chemistry, physiology, and pathophysiology","volume":"15","author":"Monte","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1021\/pr2003598","article-title":"Metabolomics of fecal extracts detects altered metabolic activity of gut microbiota in ulcerative colitis and irritable bowel syndrome","volume":"10","author":"Noor","year":"2011","journal-title":"J. Proteome Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cmet.2012.12.011","article-title":"Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation","volume":"17","author":"Bennett","year":"2013","journal-title":"Cell Metab."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1017\/S0007114508111461","article-title":"Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: A randomised controlled trial","volume":"101","author":"Laitinen","year":"2009","journal-title":"Br. J. 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