{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T21:39:37Z","timestamp":1788730777205,"version":"build-2803163510"},"reference-count":143,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Acad\u00e9mie de recherche et d\u2019enseignement sup\u00e9rieur","award":["CPO 4-8192-C0 ARES PRD"],"award-info":[{"award-number":["CPO 4-8192-C0 ARES PRD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Infertility represents a significant global health challenge affecting both men and women. Despite regular unprotected sexual intercourse, approximately 15% of couples of reproductive age struggle to conceive within 12 months, with 10% of infertility cases attributed to unknown causes worldwide. As a result, numerous studies have turned their attention to exploring the use of natural products for the prevention and treatment of infertility. Among these natural remedies is date palm pollen (DPP), a male reproductive powder derived from the blossoms of the Phoenix dactylifera L. palm tree, which has a long history of use as a dietary supplement, particularly as an aphrodisiac and fertility enhancer for both men and women. This review critically examines the diverse components of DPP, including metabolites, proteins, amino acids, fatty acids, to elucidate its potential impact on human reproduction. The analysis thoroughly assesses the composition of DPP in relation to its effects on enhancing reproductive processes and delves into its traditional uses and therapeutic benefits in male fertility, such as the enhancement of sexual desire, semen quality, and hormonal equilibrium. Similarly, it explores the influence of DPP on female fertility, emphasizing its potential to improve factors such as lubrication, desire, ovulation, and hormonal balance. Overall, this review underscores the potential of DPP as a natural remedy for addressing reproductive disorders.<\/jats:p>","DOI":"10.3390\/metabo14030166","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T04:47:05Z","timestamp":1710478025000},"page":"166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reproductive Enhancement through Phytochemical Characteristics and Biological Activities of Date Palm Pollen: A Comprehensive Review on Potential Mechanism Pathways"],"prefix":"10.3390","volume":"14","author":[{"given":"Saad","family":"Salhi","sequence":"first","affiliation":[{"name":"Animal Production Unit, Regional Center for Agricultural Research of Settat, National Institute for Agricultural Research (INRA), Avenue Ennasr, P.O. Box 415, Rabat 10090, Morocco"},{"name":"Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Techniques, Hassan First University of Settat, P.O. Box 577, Settat 26000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5832-1710","authenticated-orcid":false,"given":"Abdellatif","family":"Rahim","sequence":"additional","affiliation":[{"name":"Animal Production Unit, Regional Center for Agricultural Research of Settat, National Institute for Agricultural Research (INRA), Avenue Ennasr, P.O. Box 415, Rabat 10090, Morocco"},{"name":"Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Techniques, Hassan First University of Settat, P.O. Box 577, Settat 26000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-9350","authenticated-orcid":false,"given":"Mouad","family":"Chentouf","sequence":"additional","affiliation":[{"name":"Animal Production Unit, Regional Center for Agricultural Research of Tangier, National Institute for Agricultural Research (INRA), Avenue Ennasr, P.O. Box 415, Rabat 10090, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-4598","authenticated-orcid":false,"given":"Hasnaa","family":"Harrak","sequence":"additional","affiliation":[{"name":"Plants Improvement and Quality Unit, Regional Center for Agricultural Research of Marrakech, National Institute for Agricultural Research (INRA), Avenue Ennasr, P.O. Box 415, Rabat 10090, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Loup","family":"Bister","sequence":"additional","affiliation":[{"name":"Unit of Molecular Physiology, Faculty of Medicine, NARILIS, University of Namur, 5000 Namur, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Hamidallah","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Techniques, Hassan First University of Settat, P.O. Box 577, Settat 26000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3443-5988","authenticated-orcid":false,"given":"Bouchra","family":"El Amiri","sequence":"additional","affiliation":[{"name":"Animal Production Unit, Regional Center for Agricultural Research of Settat, National Institute for Agricultural Research (INRA), Avenue Ennasr, P.O. Box 415, Rabat 10090, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"ref_1","unstructured":"(2023, August 26). UCLA Health Infertility. Available online: https:\/\/www.uclahealth.org\/medical-services\/obgyn\/conditions-treated\/infertility."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Noh, S., Go, A., Kim, D.B., Park, M., Jeon, H.W., and Kim, B. (2020). Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential. Antioxidants, 9.","DOI":"10.3390\/antiox9100957"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Shehzad, M., Rasheed, H., Naqvi, S.A., Al-Khayri, J.M., Lorenzo, J.M., Alaghbari, M.A., Manzoor, M.F., and Aadil, R.M. (2021). Therapeutic Potential of Date Palm against Human Infertility: A Review. 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