{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:07:29Z","timestamp":1793059649839,"version":"4.5.0"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Activ\u2019Inside"},{"name":"Nouvelle Aquitaine Regional Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>The therapeutic effects of saffron have been reported and described in relation to its major derivatives. Among them, in terms of saffron\u2019s properties, crocin and crocetin absorption and bioavailability have been the most studied. Nevertheless, the metabolism of these major compounds of saffron has not yet been entirely elucidated. Current data indicate that the phase 2 metabolism of crocetins go through conjugation reactions. Crocetins could also be present in isomeric forms such as other carotenoids. Nonetheless, there are still shadow areas in regard to the measurements of the different circulating forms of crocetins after oral saffron extract administration (Safr\u2019Inside\u2122). In using various approaches, we propose the identification of a new cis isomeric form of crocetin, the 6-cis-crocetin. This compound was found in human serum samples after an oral administration of saffron extract. The 6-cis-crocetin represents 19% of the total crocetin measured after 45 min of consumption. These data mark, for the first time, the presence of a cis isomeric form of crocetin in human serum samples. Moreover, this study led to the development of an analytical method that is able to identify and quantify both isomeric forms (trans and cis).<\/jats:p>","DOI":"10.3390\/metabo14040190","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T12:09:40Z","timestamp":1711627780000},"page":"190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of Crocetin Isomers in Serum Samples via UHPLC-DAD-MS\/MS and NMR after Saffron Extract (Safr\u2019Inside\u2122) Consumption"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6335-0348","authenticated-orcid":false,"given":"Adeline","family":"Vignault","sequence":"first","affiliation":[{"name":"Activ\u2019Inside, 33750 Beychac et Caillau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Vaysse","sequence":"additional","affiliation":[{"name":"Nutrition-Health & Lipid Biochemistry Department, ITERG, 33610 Canejan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kar\u00e8ne","family":"Bertand","sequence":"additional","affiliation":[{"name":"Nutrition-Health & Lipid Biochemistry Department, ITERG, 33610 Canejan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6509-8772","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Krisa","sequence":"additional","affiliation":[{"name":"Bordeaux INP, INRAE, OENO, UMR 1366, ISVV, University of Bordeaux, 33140 Villenave d\u2019Ornon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0996-7133","authenticated-orcid":false,"given":"Arnaud","family":"Courtois","sequence":"additional","affiliation":[{"name":"Bordeaux INP, INRAE, OENO, UMR 1366, ISVV, University of Bordeaux, 33140 Villenave d\u2019Ornon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9307-9333","authenticated-orcid":false,"given":"Benjamin","family":"Moras","sequence":"additional","affiliation":[{"name":"Activ\u2019Inside, 33750 Beychac et Caillau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-8697","authenticated-orcid":false,"given":"Tristan","family":"Richard","sequence":"additional","affiliation":[{"name":"Bordeaux INP, INRAE, OENO, UMR 1366, ISVV, University of Bordeaux, 33140 Villenave d\u2019Ornon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-8274","authenticated-orcid":false,"given":"David","family":"Gaudout","sequence":"additional","affiliation":[{"name":"Activ\u2019Inside, 33750 Beychac et Caillau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-2222","authenticated-orcid":false,"given":"Line","family":"Pourtau","sequence":"additional","affiliation":[{"name":"Activ\u2019Inside, 33750 Beychac et Caillau, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Moratalla-L\u00f3pez, N., Bagur, M.J., Lorenzo, C., Mart\u00ednez-Navarro, M.E., Rosario Salinas, M., and Alonso, G.L. 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