{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:55:54Z","timestamp":1787028954532,"version":"build-2736575974"},"reference-count":202,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Basic and Applied Basic Research Fund of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515111043"],"award-info":[{"award-number":["2021A1515111043"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Basic and Applied Basic Research Fund of Guangdong Province","doi-asserted-by":"publisher","award":["82204390"],"award-info":[{"award-number":["82204390"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021A1515111043"],"award-info":[{"award-number":["2021A1515111043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204390"],"award-info":[{"award-number":["82204390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Cardiovascular disease (CVD) is recognized as the primary cause of mortality and morbidity on a global scale, and developing a clear treatment is an important tool for improving it. Cardiometabolic disorder (CMD) is a syndrome resulting from the combination of cardiovascular, endocrine, pro-thrombotic, and inflammatory health hazards. Due to their complex pathological mechanisms, there is a lack of effective diagnostic and treatment methods for cardiac metabolic disorders. Lactylation is a type of post-translational modification (PTM) that plays a regulatory role in various cellular physiological processes by inducing changes in the spatial conformation of proteins. Numerous studies have reported that lactylation modification plays a crucial role in post-translational modifications and is closely related to cardiac metabolic diseases. This article discusses the molecular biology of lactylation modifications and outlines the roles and mechanisms of lactylation modifications in cardiometabolic disorders, offering valuable insights for the diagnosis and treatment of such conditions.<\/jats:p>","DOI":"10.3390\/metabo14040217","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T09:28:06Z","timestamp":1712914086000},"page":"217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism"],"prefix":"10.3390","volume":"14","author":[{"given":"Xu","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou 510006, China"},{"name":"Guangdong Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Key Unit of Modulating Liver to Treat Hyperlipemia SATCM, State Administration of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingdong","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou 510006, China"},{"name":"Guangdong Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Key Unit of Modulating Liver to Treat Hyperlipemia SATCM, State Administration of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou 510006, China"},{"name":"Guangdong Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Key Unit of Modulating Liver to Treat Hyperlipemia SATCM, State Administration of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou 510006, China"},{"name":"Guangdong Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Key Unit of Modulating Liver to Treat Hyperlipemia SATCM, State Administration of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou 510006, China"},{"name":"Guangdong Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Key Unit of Modulating Liver to Treat Hyperlipemia SATCM, State Administration of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglu","family":"Rong","sequence":"additional","affiliation":[{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou 510006, China"},{"name":"Guangdong Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Key Unit of Modulating Liver to Treat Hyperlipemia SATCM, State Administration of Traditional Chinese Medicine, Guangzhou 510006, China"},{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Cardiovascular disease as a leading cause of death: How are pharmacists getting involved?","volume":"8","author":"Alzubaidi","year":"2019","journal-title":"Integr. Pharm. Res. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Peixoto, P., Cartron, P.-F., Serandour, A.A., and Hervouet, E. (2020). From 1957 to Nowadays: A Brief History of Epigenetics. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207571"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41467-023-35795-8","article-title":"Control of protein stability by post-translational modifications","volume":"14","author":"Lee","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Yang, T., Yi, J., He, Y., Zhang, J., Li, X., Ke, S., Xia, L., and Liu, L. (2022). Associations of Dietary Fats with All-Cause Mortality and Cardiovascular Disease Mortality among Patients with Cardiometabolic Disease. Nutrients, 14.","DOI":"10.3390\/nu14173608"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10741-019-09831-z","article-title":"Myocardial ischemia and coronary disease in heart failure","volume":"25","author":"Pagliaro","year":"2020","journal-title":"Heart Fail. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1136\/hrt.2003.025254","article-title":"Prediction and prevention of sudden cardiac death in heart failure","volume":"91","author":"Lane","year":"2005","journal-title":"Heart"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/cphy.c140055","article-title":"Pathophysiology of Heart Failure","volume":"6","author":"Tanai","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2017.10.052","article-title":"Preface: Pathology and Pharmacology of Atherosclerosis","volume":"816","author":"Foks","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/01.CIR.67.5.968","article-title":"Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study","volume":"67","author":"Hubert","year":"1983","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pharmthera.2016.03.005","article-title":"Epigenetics and obesity cardiomyopathy: From pathophysiology to prevention and management","volume":"161","author":"Zhang","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1152\/physrev.00030.2020","article-title":"Obesity cardiomyopathy: Evidence, mechanisms, and therapeutic implications","volume":"101","author":"Ren","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ncpcardio0943","article-title":"Obesity cardiomyopathy: Pathogenesis and pathophysiology","volume":"4","author":"Wong","year":"2007","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: Global epidemiology and pathogenesis","volume":"15","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pcad.2013.10.016","article-title":"Overview of epidemiology and contribution of obesity to cardiovascular disease","volume":"56","author":"Bastien","year":"2014","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1161\/CIR.0b013e318233bc6a","article-title":"Assessing adiposity: A scientific statement from the American Heart Association","volume":"124","author":"Cornier","year":"2011","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1161\/HYPERTENSIONAHA.118.11171","article-title":"Epigenetic Mechanisms and Hypertension","volume":"72","author":"Liang","year":"2018","journal-title":"Hypertension"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00109-013-0998-0","article-title":"Vascular remodeling in pulmonary hypertension","volume":"91","author":"Shimoda","year":"2013","journal-title":"J. Mol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1172\/JCI60658","article-title":"Molecular pathogenesis of pulmonary arterial hypertension","volume":"122","author":"Rabinovitch","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1801887","DOI":"10.1183\/13993003.01887-2018","article-title":"Pathology and pathobiology of pulmonary hypertension: State of the art and research perspectives","volume":"53","author":"Humbert","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.trsl.2014.06.007","article-title":"Epigenetics and arterial hypertension: The challenge of emerging evidence","volume":"165","author":"Friso","year":"2015","journal-title":"Transl. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00421-017-3795-6","article-title":"Lactate metabolism: Historical context, prior misinterpretations, and current understanding","volume":"118","author":"Ferguson","year":"2018","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.2337\/dc08-0329","article-title":"Sprint training increases muscle oxidative metabolism during high-intensity exercise in patients with type 1 diabetes","volume":"31","author":"Harmer","year":"2008","journal-title":"Diabetes Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0140-6736(05)71045-X","article-title":"Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: A prospective study","volume":"365","author":"Levy","year":"2005","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/B978-0-12-385952-5.00005-1","article-title":"Biological and pharmacological roles of HCA receptors","volume":"62","author":"Blad","year":"2011","journal-title":"Adv. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1159\/000176723","article-title":"Comparison of the kinetics and utilisation of D(\u2212)-and L(+)-sodium lactate in normal man","volume":"27","author":"Connor","year":"1983","journal-title":"Ann. Nutr. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ccr.2008.05.005","article-title":"Tumor cell metabolism: Cancer\u2019s Achilles\u2019 heel","volume":"13","author":"Kroemer","year":"2008","journal-title":"Cancer Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","article-title":"Lactate: The ugly duckling of energy metabolism","volume":"2","author":"Rabinowitz","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3389\/fonc.2019.01143","article-title":"Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches","volume":"9","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bpa.12299","article-title":"The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor","volume":"26","author":"Valvona","year":"2016","journal-title":"Brain Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"19345","DOI":"10.1073\/pnas.0709747104","article-title":"Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis","volume":"104","author":"DeBerardinis","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1096\/fj.07-8174com","article-title":"Lactate sensitive transcription factor network in L6 cells: Activation of MCT1 and mitochondrial biogenesis","volume":"21","author":"Hashimoto","year":"2007","journal-title":"FASEB J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1042\/bst0300258","article-title":"Lactate shuttles in nature","volume":"30","author":"Brooks","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Chandel, N.S. (2021). Carbohydrate Metabolism. Cold Spring Harb. Perspect. Biol., 13.","DOI":"10.1101\/cshperspect.a040568"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3389\/fendo.2018.00802","article-title":"Unraveling the Regulation of Hepatic Gluconeogenesis","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1113\/jphysiol.2009.178350","article-title":"Cell-cell and intracellular lactate shuttles","volume":"587","author":"Brooks","year":"2009","journal-title":"J. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0006-291X(03)00550-3","article-title":"Peroxisomal membrane monocarboxylate transporters: Evidence for a redox shuttle system?","volume":"304","author":"McClelland","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1152\/jappl.1999.87.5.1713","article-title":"Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1","volume":"87","author":"Brooks","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1152\/japplphysiol.00009.2004","article-title":"MCT1 confirmed in rat striated muscle mitochondria","volume":"97","author":"Butz","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Brooks, G.A. (2020). Lactate as a fulcrum of metabolism. Redox Biol., 35.","DOI":"10.1016\/j.redox.2020.101454"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1124\/pr.119.018762","article-title":"Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease","volume":"72","author":"Felmlee","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e1194","DOI":"10.1097\/CCM.0000000000004589","article-title":"A Study of Associations Between Plasma Metformin Concentration, Lactic Acidosis, and Mortality in an Emergency Hospitalization Context","volume":"48","author":"Bennis","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tibs.2018.10.011","article-title":"Lactate: A Metabolic Driver in the Tumour Landscape","volume":"44","author":"Ippolito","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"ref_44","first-page":"2827","article-title":"Blood lactate monitoring in critically ill patients: A systematic health technology assessment","volume":"37","author":"Jansen","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/eji.201646477","article-title":"Lactate at the crossroads of metabolism, inflammation, and autoimmunity","volume":"47","author":"Pucino","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1152\/jappl.1999.87.5.1684","article-title":"Active muscle and whole body lactate kinetics after endurance training in men","volume":"87","author":"Bergman","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1038\/s41467-019-10427-2","article-title":"Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer","volume":"10","author":"Jin","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1038\/ncomms4284","article-title":"Lactate-mediated glia-neuronal signalling in the mammalian brain","volume":"5","author":"Tang","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/14728222.2018.1511706","article-title":"Lactate transporters as therapeutic targets in cancer and inflammatory diseases","volume":"22","author":"Pucino","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.cmet.2021.07.008","article-title":"Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis","volume":"33","author":"Pozo","year":"2021","journal-title":"Cell Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1152\/physrev.00062.2017","article-title":"Brain Glucose Metabolism: Integration of Energetics with Function","volume":"99","author":"Dienel","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fonc.2018.00081","article-title":"Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses","volume":"8","author":"Morrot","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/08830185.2021.1955876","article-title":"Lactic acid in macrophage polarization: The significant role in inflammation and cancer","volume":"41","author":"Zhou","year":"2022","journal-title":"Int. Rev. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/08830185.2021.1974856","article-title":"Effects of lactate in immunosuppression and inflammation: Progress and prospects","volume":"41","author":"Luo","year":"2022","journal-title":"Int. Rev. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/cns.12362","article-title":"Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury","volume":"21","author":"Shen","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000343657","article-title":"New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: Extended benefit after intracerebroventricular injection and efficacy of intravenous administration","volume":"34","author":"Berthet","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmet.2016.08.011","article-title":"LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells","volume":"24","author":"Brand","year":"2016","journal-title":"Cell Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1002\/art.41420","article-title":"Effect of Increased Lactate Dehydrogenase A Activity and Aerobic Glycolysis on the Proinflammatory Profile of Autoimmune CD8+ T Cells in Rheumatoid Arthritis","volume":"72","author":"Klika","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.cmet.2020.05.004","article-title":"Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Metab."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1016\/j.febslet.2008.09.042","article-title":"Mitochondria and L-lactate metabolism","volume":"582","author":"Passarella","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1097\/00005768-199907000-00011","article-title":"Exercise training-induced alterations in skeletal muscle antioxidant capacity: A brief review","volume":"31","author":"Powers","year":"1999","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/cphy.c100054","article-title":"Reactive oxygen species: Impact on skeletal muscle","volume":"1","author":"Powers","year":"2011","journal-title":"Compr. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.febslet.2010.03.038","article-title":"L-lactate generates hydrogen peroxide in purified rat liver mitochondria due to the putative L-lactate oxidase localized in the intermembrane space","volume":"584","author":"Valenti","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cmet.2017.03.008","article-title":"GPCR-Mediated Signaling of Metabolites","volume":"25","author":"Husted","year":"2017","journal-title":"Cell Metab."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fonc.2020.00231","article-title":"Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy","volume":"10","author":"Baltazar","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3389\/fphys.2013.00354","article-title":"Acidic tumor microenvironment and pH-sensing G protein-coupled receptors","volume":"4","author":"Justus","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1152\/physiol.00016.2017","article-title":"Lactic Acid: No Longer an Inert and End-Product of Glycolysis","volume":"32","author":"Sun","year":"2017","journal-title":"Physiology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1074\/jbc.M806409200","article-title":"Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81","volume":"284","author":"Liu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"60.e1","DOI":"10.1016\/j.ajog.2016.09.072","article-title":"Lactate produced during labor modulates uterine inflammation via GPR81(HCA1)","volume":"216","author":"Madaan","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1053\/j.gastro.2014.03.014","article-title":"Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity","volume":"146","author":"Hoque","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Errea, A., Cayet, D., Marchetti, P., Tang, C., Kluza, J., Offermanns, S., Sirard, J.-C., and Rumbo, M. (2016). Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163694"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1167\/iovs.18-25458","article-title":"Dual Properties of Lactate in M\u00fcller Cells: The Effect of GPR81 Activation","volume":"60","author":"Vohra","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Bozzo, L., Puyal, J., and Chatton, J.-Y. (2013). Lactate modulates the activity of primary cortical neurons through a receptor-mediated pathway. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071721"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.bbrc.2018.06.069","article-title":"Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling","volume":"503","author":"Wu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.4049\/jimmunol.1700604","article-title":"GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis","volume":"200","author":"Ranganathan","year":"2018","journal-title":"J. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1161\/HYPERTENSIONAHA.119.14308","article-title":"Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation","volume":"75","author":"Jones","year":"2020","journal-title":"Hypertension"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e92564","DOI":"10.1172\/jci.insight.92564","article-title":"Involvement of the metabolic sensor GPR81 in cardiovascular control","volume":"2","author":"Wallenius","year":"2017","journal-title":"JCI Insight"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1002\/iub.2151","article-title":"Activation of GPR81 by lactate inhibits oscillatory shear stress-induced endothelial inflammation by activating the expression of KLF2","volume":"71","author":"Sun","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"70898","DOI":"10.18632\/oncotarget.12286","article-title":"G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1158\/0008-5472.CAN-14-0319","article-title":"Cell surface lactate receptor GPR81 is crucial for cancer cell survival","volume":"74","author":"Roland","year":"2014","journal-title":"Cancer Res."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Longhitano, L., Forte, S., Orlando, L., Grasso, S., Barbato, A., Vicario, N., Parenti, R., Fontana, P., Amorini, A.M., and Lazzarino, G. (2022). The Crosstalk between GPR81\/IGFBP6 Promotes Breast Cancer Progression by Modulating Lactate Metabolism and Oxidative Stress. Antioxidants, 11.","DOI":"10.3390\/antiox11020275"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.bbrc.2008.10.088","article-title":"Role of GPR81 in lactate-mediated reduction of adipose lipolysis","volume":"377","author":"Cai","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"8633","DOI":"10.4049\/jimmunol.181.12.8633","article-title":"Adenosine 5\u2032-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype","volume":"181","author":"Sag","year":"2008","journal-title":"J. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e2102434118","DOI":"10.1073\/pnas.2102434118","article-title":"The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages","volume":"118","author":"Vadevoo","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1073\/pnas.1614035114","article-title":"Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis","volume":"114","author":"Chen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Chen, H., Venkat, S., McGuire, P., Gan, Q., and Fan, C. (2018). Recent Development of Genetic Code Expansion for Posttranslational Modification Studies. Molecules, 23.","DOI":"10.3390\/molecules23071662"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41417-022-00464-3","article-title":"Protein post-translational modifications in the regulation of cancer hallmarks","volume":"30","author":"Wang","year":"2023","journal-title":"Cancer Gene Ther."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.chembiol.2019.11.005","article-title":"Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes","volume":"27","author":"Gaffney","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Varner, E.L., Trefely, S., Bartee, D., von Krusenstiern, E., Izzo, L., Bekeova, C., O\u2019Connor, R.S., Seifert, E.L., Wellen, K.E., and Meier, J.L. (2020). Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues. Open Biol., 10.","DOI":"10.1098\/rsob.200187"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Neumann-Staubitz, P., Lammers, M., and Neumann, H. (2021). Genetic Code Expansion Tools to Study Lysine Acylation. Adv. Biol., 5.","DOI":"10.1002\/adbi.202100926"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1126\/science.1179689","article-title":"Regulation of cellular metabolism by protein lysine acetylation","volume":"327","author":"Zhao","year":"2010","journal-title":"Science"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.celrep.2017.02.018","article-title":"Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II","volume":"18","author":"James","year":"2017","journal-title":"Cell Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.tibs.2018.07.002","article-title":"The Causes and Consequences of Nonenzymatic Protein Acylation","volume":"43","author":"James","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1074\/mcp.R114.046664","article-title":"Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation","volume":"14","author":"Hirschey","year":"2015","journal-title":"Mol. Cell. Proteom."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.molcel.2018.04.011","article-title":"p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis","volume":"70","author":"Huang","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.devcel.2020.06.036","article-title":"Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins","volume":"54","author":"Figlia","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1165\/rcmb.2020-0360OC","article-title":"Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation","volume":"64","author":"Cui","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","article-title":"Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis","volume":"29","author":"Yang","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/JPER.23-0241","article-title":"Study on the effect of protein lysine lactylation modification in macrophages on inhibiting periodontitis in rats","volume":"95","author":"Liu","year":"2023","journal-title":"J. Periodontol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"eabi6696","DOI":"10.1126\/sciadv.abi6696","article-title":"Class I histone deacetylases (HDAC1-3) are histone lysine delactylases","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"dev200049","DOI":"10.1242\/dev.200049","article-title":"Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development","volume":"149","author":"Dai","year":"2022","journal-title":"Development"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1021\/acschembio.1c00863","article-title":"Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms","volume":"17","author":"Zessin","year":"2022","journal-title":"ACS Chem. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"107757","DOI":"10.1016\/j.isci.2023.107757","article-title":"Identification of SIRT3 as an eraser of H4K16la","volume":"26","author":"Fan","year":"2023","journal-title":"iScience"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"109820","DOI":"10.1016\/j.celrep.2021.109820","article-title":"Protein lactylation induced by neural excitation","volume":"37","author":"Hagihara","year":"2021","journal-title":"Cell Rep."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Zhang, N., Jiang, N., Yu, L., Guan, T., Sang, X., Feng, Y., Chen, R., and Chen, Q. (2021). Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.719720"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Gao, M., Zhang, N., and Liang, W. (2020). Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinerea. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.594743"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1021\/acs.jafc.1c00760","article-title":"Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains","volume":"69","author":"Meng","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s11427-023-2361-1","article-title":"Trash to treasure: Lactate and protein lactylation in maize root impacts response to drought","volume":"66","author":"Shi","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"104630","DOI":"10.1016\/j.isci.2022.104630","article-title":"Identification of lysine-lactylated substrates in gastric cancer cells","volume":"25","author":"Yang","year":"2022","journal-title":"iScience"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13071-022-05315-6","article-title":"Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii","volume":"15","author":"Zhao","year":"2022","journal-title":"Parasit. Vectors"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1014225","DOI":"10.3389\/fgene.2022.1014225","article-title":"Comprehensive analysis of lysine lactylation in Frankliniella occidentalis","volume":"13","author":"An","year":"2022","journal-title":"Front. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Yin, D., Jiang, N., Cheng, C., Sang, X., Feng, Y., Chen, R., and Chen, Q. (2022). Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii. Genom. Proteom. Bioinform., in press.","DOI":"10.1101\/2022.05.19.492655"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"966457","DOI":"10.3389\/fimmu.2022.966457","article-title":"Post-translational changes in Phialophora verrucosa via lysine lactylation during prolonged presence in a patient with a CARD9-related immune disorder","volume":"13","author":"Song","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/acs.jproteome.2c00756","article-title":"Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy","volume":"22","author":"Lin","year":"2023","journal-title":"J. Proteome Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"10107","DOI":"10.1021\/acs.jafc.3c00122","article-title":"Novel Insight of Nitrogen Deprivation Affected Lipid Accumulation by Genome-Wide Lactylation in Nannochloropsis oceanica","volume":"71","author":"Wang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"10004","DOI":"10.1021\/acs.jafc.3c01886","article-title":"Deciphering the Atlas of Post-Translational Modification in Sugarcane","volume":"71","author":"Wu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e2300003","DOI":"10.1002\/pmic.202300003","article-title":"In-depth discovery of protein lactylation in hepatocellular carcinoma","volume":"23","author":"Wu","year":"2023","journal-title":"Proteomics"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Wang, X., Fan, W., Li, N., Ma, Y., Yao, M., Wang, G., He, S., Li, W., Tan, J., and Lu, Q. (2023). YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2. Genome Biol., 24.","DOI":"10.1186\/s13059-023-02931-y"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e2200437","DOI":"10.1002\/pmic.202200437","article-title":"Global profiling of lysine lactylation in human lungs","volume":"23","author":"Yang","year":"2023","journal-title":"Proteomics"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s10571-022-01277-6","article-title":"Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia\u2014Reperfusion Injury Rats","volume":"43","author":"Yao","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s42255-022-00710-w","article-title":"Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma","volume":"5","author":"Yang","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"108645","DOI":"10.1016\/j.isci.2023.108645","article-title":"Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells","volume":"27","author":"Cheng","year":"2024","journal-title":"iScience"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.molcel.2022.02.033","article-title":"Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells","volume":"82","author":"Xiong","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"110986","DOI":"10.1016\/j.celrep.2022.110986","article-title":"Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-\u03b2 signaling in regulatory T cells","volume":"39","author":"Gu","year":"2022","journal-title":"Cell Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41592-022-01523-1","article-title":"Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome","volume":"19","author":"Wan","year":"2022","journal-title":"Nat. Methods"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.7150\/ijbs.85656","article-title":"CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1","volume":"19","author":"Liao","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.cell.2023.11.022","article-title":"Metabolic regulation of homologous recombination repair by MRE11 lactylation","volume":"187","author":"Chen","year":"2024","journal-title":"Cell"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13046-024-02943-x","article-title":"Lactylation stabilizes DCBLD1 activating the pentose phosphate pathway to promote cervical cancer progression","volume":"43","author":"Meng","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"30628","DOI":"10.1073\/pnas.2009778117","article-title":"TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation","volume":"117","author":"McDaniel","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1016\/j.csbj.2021.08.013","article-title":"FSL-Kla: A few-shot learning-based multi-feature hybrid system for lactylation site prediction","volume":"19","author":"Jiang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Lai, F.-L., and Gao, F. (2023). Auto-Kla: A novel web server to discriminate lysine lactylation sites using automated machine learning. Brief. Bioinform., 24.","DOI":"10.1093\/bib\/bbad070"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physrev.00015.2009","article-title":"Myocardial fatty acid metabolism in health and disease","volume":"90","author":"Lopaschuk","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fcvm.2018.00068","article-title":"Loss of Metabolic Flexibility in the Failing Heart","volume":"5","author":"Karwi","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1748-1716.2010.02122.x","article-title":"Lactate kinetics in human tissues at rest and during exercise","volume":"199","year":"2010","journal-title":"Acta Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1126\/science.abc8861","article-title":"Comprehensive quantification of fuel use by the failing and nonfailing human heart","volume":"370","author":"Murashige","year":"2020","journal-title":"Science"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"108087","DOI":"10.1016\/j.celrep.2020.108087","article-title":"Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress","volume":"32","author":"Dai","year":"2020","journal-title":"Cell Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cmet.2018.03.008","article-title":"The Science and Translation of Lactate Shuttle Theory","volume":"27","author":"Brooks","year":"2018","journal-title":"Cell Metab."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nchembio.2172","article-title":"Lactate metabolism is associated with mammalian mitochondria","volume":"12","author":"Chen","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/s42255-020-0267-9","article-title":"Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade","volume":"2","author":"Li","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/CIRCRESAHA.122.320488","article-title":"Histone Lactylation Boosts Reparative Gene Activation Post-Myocardial Infarction","volume":"131","author":"Wang","year":"2022","journal-title":"Circ. Res."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Haege, E.R., Huang, H.-C., and Huang, C.-C. (2021). Identification of Lactate as a Cardiac Protectant by Inhibiting Inflammation and Cardiac Hypertrophy Using a Zebrafish Acute Heart Failure Model. Pharmaceuticals, 14.","DOI":"10.3390\/ph14030261"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"R48","DOI":"10.1186\/cc13793","article-title":"Half-molar sodium lactate infusion improves cardiac performance in acute heart failure: A pilot randomised controlled clinical trial","volume":"18","author":"Nalos","year":"2014","journal-title":"Crit. Care"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/ejhf.1156","article-title":"Increased blood lactate is prevalent and identifies poor prognosis in patients with acute heart failure without overt peripheral hypoperfusion","volume":"20","author":"Biegus","year":"2018","journal-title":"Eur. J. Heart Fail."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"eadc9465","DOI":"10.1126\/sciadv.adc9465","article-title":"Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction","volume":"9","author":"Fan","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41422-023-00844-w","article-title":"\u03b1-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure","volume":"33","author":"Zhang","year":"2023","journal-title":"Cell Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1161\/CIRCRESAHA.117.311819","article-title":"Lactate Promotes Synthetic Phenotype in Vascular Smooth Muscle Cells","volume":"121","author":"Yang","year":"2017","journal-title":"Circ. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cca.2020.06.044","article-title":"Pyroptosis: A pro-inflammatory type of cell death in cardiovascular disease","volume":"510","author":"Wang","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"112869","DOI":"10.1016\/j.celrep.2023.112869","article-title":"Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia","volume":"42","author":"Xu","year":"2023","journal-title":"Cell Rep."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"808799","DOI":"10.3389\/fimmu.2021.808799","article-title":"Role of Lactate in Inflammatory Processes: Friend or Foe","volume":"12","author":"Manosalva","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.atherosclerosis.2023.05.009","article-title":"Exercise-induced endothelial Mecp2 lactylation suppresses atherosclerosis via the Ereg\/MAPK signalling pathway","volume":"375","author":"Wang","year":"2023","journal-title":"Atherosclerosis"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s41590-018-0226-8","article-title":"Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages","volume":"19","author":"Bohn","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis","volume":"145","author":"Moore","year":"2011","journal-title":"Cell"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Wang, J., Liu, Z., Xu, Y., Wang, Y., Wang, F., Zhang, Q., Ni, C., Zhen, Y., Xu, R., and Liu, Q. (2022). Enterobacterial LPS-inducible LINC00152 is regulated by histone lactylation and promotes cancer cells invasion and migration. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.913815"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1194\/jlr.R050252","article-title":"Acidification of the intimal fluid: The perfect storm for atherogenesis","volume":"56","author":"Nguyen","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0021-9150(02)00018-7","article-title":"pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque","volume":"164","author":"Naghavi","year":"2002","journal-title":"Atherosclerosis"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bbalip.2011.10.014","article-title":"Acidity and lipolysis by group V secreted phospholipase A(2) strongly increase the binding of apoB-100-containing lipoproteins to human aortic proteoglycans","volume":"1821","author":"Jauhiainen","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"37449","DOI":"10.1074\/jbc.M508565200","article-title":"Decrease in pH strongly enhances binding of native, proteolyzed, lipolyzed, and oxidized low density lipoprotein particles to human aortic proteoglycans","volume":"280","author":"Sneck","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"C404","DOI":"10.1152\/ajpcell.00214.2018","article-title":"A physiological drop in pH decreases mitochondrial respiration, and HDAC and Akt signaling, in L6 myocytes","volume":"316","author":"Genders","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Wang, C., Wang, S., Wang, Z., Han, J., Jiang, N., Qu, L., and Xu, K. (2024). Andrographolide regulates H3 histone lactylation by interfering with p300 to alleviate aortic valve calcification. Br. J. Pharmacol.","DOI":"10.1111\/bph.16332"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0014-5793(71)80200-4","article-title":"The transport of pyruvate in rat liver mitochondria","volume":"12","author":"Papa","year":"1971","journal-title":"FEBS Lett."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1074\/jbc.M116.753509","article-title":"Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: Role of Mitochondrial Pyruvate Carrier 2 (MPC2) Acetylation","volume":"292","author":"Vadvalkar","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1097\/HEP.0000000000000279","article-title":"Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease","volume":"78","author":"Gao","year":"2023","journal-title":"Hepatology"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Chen, X., Huang, W., Zhang, J., Li, Y., Xing, Z., Guo, L., Jiang, H., and Zhang, J. (2023). High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis. BMC Biol., 21.","DOI":"10.1186\/s12915-023-01698-9"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13148-023-01573-y","article-title":"Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis","volume":"15","author":"Yin","year":"2023","journal-title":"Clin. Epigenetics"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.2337\/diab.37.8.1020","article-title":"Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0026-0495(92)90185-D","article-title":"Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin","volume":"41","author":"Lovejoy","year":"1992","journal-title":"Metabolism"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/ajh.2008.282","article-title":"Association of lactate with blood pressure before and after rapid weight loss","volume":"21","author":"Crawford","year":"2008","journal-title":"Am. J. Hypertens."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/oby.22129","article-title":"Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial","volume":"26","author":"Chondronikola","year":"2018","journal-title":"Obesity"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2337\/diab.30.12.1000","article-title":"The effect of insulin on the disposal of intravenous glucose: Results from indirect calorimetry and hepatic and femoral venous catheterization","volume":"30","author":"DeFronzo","year":"1981","journal-title":"Diabetes"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"951390","DOI":"10.3389\/fphys.2022.951390","article-title":"Lactate-induced lactylation in skeletal muscle is associated with insulin resistance in humans","volume":"13","author":"Maschari","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s44321-024-00025-1","article-title":"Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy","volume":"16","author":"Chen","year":"2024","journal-title":"EMBO Mol. Med."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Zhou, R., Ding, R.-C., Yu, Q., Qiu, C.-Z., Zhang, H.-Y., Yin, Z.-J., and Ren, D.-L. (2024). Metformin Attenuates Neutrophil Recruitment through the H3K18 Lactylation\/Reactive Oxygen Species Pathway in Zebrafish. Antioxidants, 13.","DOI":"10.3390\/antiox13020176"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.jacc.2009.04.018","article-title":"Cellular and molecular basis of pulmonary arterial hypertension","volume":"54","author":"Morrell","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/CIRCRESAHA.115.301130","article-title":"The metabolic theory of pulmonary arterial hypertension","volume":"115","author":"Paulin","year":"2014","journal-title":"Circ. Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.cmet.2014.01.004","article-title":"The metabolic basis of pulmonary arterial hypertension","volume":"19","author":"Sutendra","year":"2014","journal-title":"Cell Metab."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1161\/CIRCULATIONAHA.114.006979","article-title":"Emerging concepts in the molecular basis of pulmonary arterial hypertension: Part I: Metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension","volume":"131","author":"Ryan","year":"2015","journal-title":"Circulation"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2015.05.042","article-title":"Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension","volume":"87","author":"Adesina","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1701024","DOI":"10.1183\/13993003.01024-2017","article-title":"Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension","volume":"51","author":"Pak","year":"2018","journal-title":"Eur. Respir. J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"eaba0694","DOI":"10.1126\/sciadv.aba0694","article-title":"Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing","volume":"6","author":"Sommer","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Chen, J., Zhang, M., Liu, Y., Zhao, S., Wang, Y., Wang, M., Niu, W., Jin, F., and Li, Z. (2023). Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension. J. Mol. Cell Biol., 14.","DOI":"10.1093\/jmcb\/mjac073"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"119366","DOI":"10.1016\/j.lfs.2021.119366","article-title":"The m6A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension","volume":"274","author":"Qin","year":"2021","journal-title":"Life Sci."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Yu, J., Chai, P., Xie, M., Ge, S., Ruan, J., Fan, X., and Jia, R. (2021). Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma. Genome Biol., 22.","DOI":"10.1186\/s13059-021-02308-z"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41419-020-2235-4","article-title":"YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A\/mRNA pathway","volume":"11","author":"Huang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.molcel.2020.12.026","article-title":"R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO\/m6A\/PFKP\/LDHB axis","volume":"81","author":"Qing","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41586-019-1016-7","article-title":"Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally","volume":"567","author":"Huang","year":"2019","journal-title":"Nature"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.18632\/aging.202616","article-title":"SEDT2\/METTL14-mediated m6A methylation awakening contributes to hypoxia-induced pulmonary arterial hypertension in mice","volume":"13","author":"Zhou","year":"2021","journal-title":"Aging"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.chom.2018.11.002","article-title":"Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development","volume":"24","author":"Lee","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"106238","DOI":"10.1016\/j.phrs.2022.106238","article-title":"Immunity and inflammation in pulmonary arterial hypertension: From pathophysiology mechanisms to treatment perspective","volume":"180","author":"Wang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1089\/nat.2020.0921","article-title":"Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides","volume":"31","author":"Holgersen","year":"2021","journal-title":"Nucleic Acid Ther."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.immuni.2019.11.008","article-title":"Sweet Temptation: From Sugar Metabolism to Gene Regulation","volume":"51","author":"Notarangelo","year":"2019","journal-title":"Immunity"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJMra2022774","article-title":"Autophagy in Human Diseases","volume":"383","author":"Mizushima","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-physiol-021317-121427","article-title":"The Role of Autophagy in the Heart","volume":"80","author":"Sciarretta","year":"2018","journal-title":"Annu. Rev. Physiol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"eadg4993","DOI":"10.1126\/sciadv.adg4993","article-title":"ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation","volume":"9","author":"Jia","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_196","first-page":"1","article-title":"Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer","volume":"20","author":"Li","year":"2023","journal-title":"Autophagy"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12043","article-title":"Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization","volume":"496","author":"Sarraf","year":"2013","journal-title":"Nature"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"112033","DOI":"10.1016\/j.celrep.2023.112033","article-title":"Numb\/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation","volume":"42","author":"He","year":"2023","journal-title":"Cell Rep."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1111\/bph.15837","article-title":"Honokiol ameliorates cisplatin-induced acute kidney injury via inhibition of mitochondrial fission","volume":"179","author":"Mao","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41586-021-03510-6","article-title":"Distinct fission signatures predict mitochondrial degradation or biogenesis","volume":"593","author":"Kleele","year":"2021","journal-title":"Nature"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/10985549.2023.2253131","article-title":"Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation","volume":"43","author":"Susser","year":"2023","journal-title":"Mol. Cell. Biol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41422-023-00864-6","article-title":"Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation","volume":"34","author":"Mao","year":"2024","journal-title":"Cell Res."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/14\/4\/217\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:27:00Z","timestamp":1760106420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/14\/4\/217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":202,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["metabo14040217"],"URL":"https:\/\/doi.org\/10.3390\/metabo14040217","relation":{},"ISSN":["2218-1989"],"issn-type":[{"value":"2218-1989","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,12]]}}}