{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:10:45Z","timestamp":1760109045590,"version":"build-2065373602"},"reference-count":86,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES Brazil","doi-asserted-by":"publisher","award":["001","#310157\/2023-4","2016\/18517-8"],"award-info":[{"award-number":["001","#310157\/2023-4","2016\/18517-8"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CNPq\u2014Brazil","award":["001","#310157\/2023-4","2016\/18517-8"],"award-info":[{"award-number":["001","#310157\/2023-4","2016\/18517-8"]}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["001","#310157\/2023-4","2016\/18517-8"],"award-info":[{"award-number":["001","#310157\/2023-4","2016\/18517-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Compounds of natural or synthetic origin present in personal care products, food additives, and packaging may interfere with hormonal regulation and are called endocrine-disrupting chemicals (EDCs). The thyroid gland is an important target of these compounds. The objective of this study was to analyze public data on the human thyroid transcriptome and investigate potential new targets of EDCs in the embryonic and adult thyroid glands. We compared the public transcriptome data of adult and embryonic human thyroid glands and selected 100 up- or downregulated genes that were subsequently subjected to functional enrichment analysis. In the embryonic thyroid, the most highly expressed gene was PRMT6, which methylates arginine-4 of histone H2A (86.21%), and the downregulated clusters included plasma lipoprotein particles (39.24%) and endopeptidase inhibitory activity (24.05%). For the adult thyroid gland, the most highly expressed genes were related to the following categories: metallothionein-binding metals (56.67%), steroid hormone biosynthetic process (16.67%), and cellular response to vascular endothelial growth factor stimulus (6.67%). Several compounds ranging from antihypertensive drugs to enzyme inhibitors were identified as potentially harmful to thyroid gland development and adult function.<\/jats:p>","DOI":"10.3390\/metabo14040226","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T08:41:06Z","timestamp":1713256866000},"page":"226","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A System Biology Approach Reveals New Targets for Human Thyroid Gland Toxicity in Embryos and Adult Individuals"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4373-738X","authenticated-orcid":false,"given":"Jeane Maria","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Medicine, Laboratory of Reproductive Toxicology, State University of the Midwest (UNICENTRO), Alameda \u00c9lio Antonio Dalla Vecchia, n\u00ba 838, Guarapuava 85040-167, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamilli","family":"Zenzeluk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laboratory of Reproductive Toxicology, State University of the Midwest (UNICENTRO), Alameda \u00c9lio Antonio Dalla Vecchia, n\u00ba 838, Guarapuava 85040-167, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9146-6583","authenticated-orcid":false,"given":"Caroline","family":"Serrano-Nascimento","sequence":"additional","affiliation":[{"name":"Institute of Environmental, Chemical and Pharmaceutical Sciences (ICAQF), Department of Biological Sciences, Federal University of S\u00e3o Paulo (UNIFESP), Rua Professor Arthur Riedel, 275, Diadema 09972-270, SP, Brazil"},{"name":"Department of Medicine, Laboratory of Molecular and Translational Endocrinology Medicine, Federal University of S\u00e3o Paulo (UNIFESP), Rua Pedro de Toledo, 669-11\u00ba andar-L11E, S\u00e3o Paulo 04039-032, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Aurelio","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laboratory of Reproductive Toxicology, State University of the Midwest (UNICENTRO), Alameda \u00c9lio Antonio Dalla Vecchia, n\u00ba 838, Guarapuava 85040-167, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-4226","authenticated-orcid":false,"given":"Renata Marino","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Laboratory of Reproductive Toxicology, State University of the Midwest (UNICENTRO), Alameda \u00c9lio Antonio Dalla Vecchia, n\u00ba 838, Guarapuava 85040-167, PR, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chi, H.C., Chen, C.Y., Tsai, M.M., Tsai, C.Y., and Lin, K.H. 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