{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:22:40Z","timestamp":1787311360693,"version":"build-2736575974"},"reference-count":32,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RMIT University","award":["LP180101085"],"award-info":[{"award-number":["LP180101085"]}]},{"name":"RMIT University","award":["LP220200614"],"award-info":[{"award-number":["LP220200614"]}]},{"name":"Australian Research Council","award":["LP180101085"],"award-info":[{"award-number":["LP180101085"]}]},{"name":"Australian Research Council","award":["LP220200614"],"award-info":[{"award-number":["LP220200614"]}]},{"name":"Wellcome Trust (UK)","award":["LP180101085"],"award-info":[{"award-number":["LP180101085"]}]},{"name":"Wellcome Trust (UK)","award":["LP220200614"],"award-info":[{"award-number":["LP220200614"]}]},{"name":"University of Queensland (Australia)","award":["LP180101085"],"award-info":[{"award-number":["LP180101085"]}]},{"name":"University of Queensland (Australia)","award":["LP220200614"],"award-info":[{"award-number":["LP220200614"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Phytochemical profiling followed by antimicrobial and anthelmintic activity evaluation of the Australian plant Geijera parviflora, known for its customary use in Indigenous Australian ceremonies and bush medicine, was performed. In the present study, seven previously reported compounds were isolated including auraptene, 6\u2032-dehydromarmin, geiparvarin, marmin acetonide, flindersine, and two flindersine derivatives from the bark and leaves, together with a new compound, chlorogeiparvarin, formed as an artefact during the isolation procedure and isolated as a mixture with geiparvarin. Chemical profiling allowed for a qualitative and quantitative comparison of the compounds in the leaves, bark, flowers, and fruit of this plant. Subsequently, a subset of these compounds as well as crude extracts from the plant were evaluated for their antimicrobial and anthelmintic activities. Anthelmintic activity assays showed that two of the isolated compounds, auraptene and flindersine, as well as the dichloromethane and methanol crude extracts of G. parviflora, displayed significant activity against a parasitic nematode (Haemonchus contortus). This is the first report of the anthelmintic activity associated with these compounds and indicates the importance of such fundamental explorations for the discovery of bioactive phytochemicals for therapeutic application(s).<\/jats:p>","DOI":"10.3390\/metabo14050259","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T08:02:22Z","timestamp":1714723342000},"page":"259","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Phytochemical Profiling Studies of Alkaloids and Coumarins from the Australian Plant Geijera parviflora Lindl. (Rutaceae) and Their Anthelmintic and Antimicrobial Assessment"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7894-3530","authenticated-orcid":false,"given":"Deepika","family":"Dugan","sequence":"first","affiliation":[{"name":"Marine and Terrestrial Natural Product (MATNAP) Research Group, School of Science (Applied Chemistry and Environmental Science), RMIT University, Melbourne, VIC 3001, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael J.","family":"Bell","sequence":"additional","affiliation":[{"name":"Marine and Terrestrial Natural Product (MATNAP) Research Group, School of Science (Applied Chemistry and Environmental Science), RMIT University, Melbourne, VIC 3001, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-2276","authenticated-orcid":false,"given":"Robert","family":"Brklja\u010da","sequence":"additional","affiliation":[{"name":"Monash Biomedical Imaging, Monash University, Clayton, VIC 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7135-6598","authenticated-orcid":false,"given":"Colin","family":"Rix","sequence":"additional","affiliation":[{"name":"Marine and Terrestrial Natural Product (MATNAP) Research Group, School of Science (Applied Chemistry and Environmental Science), RMIT University, Melbourne, VIC 3001, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-4367","authenticated-orcid":false,"given":"Aya C.","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, Faculty of Science, Melbourne Veterinary School, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4423-1690","authenticated-orcid":false,"given":"Robin B.","family":"Gasser","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, Faculty of Science, Melbourne Veterinary School, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-4260","authenticated-orcid":false,"given":"Sylvia","family":"Urban","sequence":"additional","affiliation":[{"name":"Marine and Terrestrial Natural Product (MATNAP) Research Group, School of Science (Applied Chemistry and Environmental Science), RMIT University, Melbourne, VIC 3001, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.fitote.2013.12.008","article-title":"Antibacterial anthranilic acid derivatives from Geijera parviflora","volume":"93","author":"Shou","year":"2014","journal-title":"Fitoterapia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1021\/ed009p429","article-title":"Natural Chemical Resources of Australian Plant Products. 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