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Eicosanoids are a group of bioactive metabolites that are mainly oxidized by arachidonic acid. Eicosanoids play a diverse role in cardiovascular diseases, with some exerting beneficial effects while others have detrimental consequences. However, a causal relationship between eicosanoid levels and cardiovascular disease remains unclear. Six single nucleotide polymorphisms (SNPs) with strong associations with plasma eicosanoid levels were selected. Summary-level data for cardiovascular disease were obtained from publicly available genome-wide association studies. A two-sample MR analysis identified that plasma eicosanoid levels were inversely correlated with unstable angina pectoris (OR 1.06; 95% CI 1\u20131.12; p = 0.04), myocardial infarction (OR 1.05; 95% CI 1.02\u20131.09; p = 0.005), ischemia stroke (OR 1.05; 95% CI 1\u20131.11; p = 0.047), transient ischemic attack (OR 1.03; 95% CI 1\u20131.07; p = 0.042), heart failure (OR 1.03; 95% CI 1.01\u20131.05; p = 0.011), and pulmonary embolism (OR 1.08; 95% CI 1.02\u20131.14; p = 1.69 \u00d7 10\u22126). In conclusion, our data strongly suggest a genetic causal link between high plasma eicosanoid levels and an increased cardiovascular disease risk. This study provides genetic evidence for treating cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/metabo14060294","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T03:49:03Z","timestamp":1716436143000},"page":"294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic Evidence for Causal Relationships between Plasma Eicosanoid Levels and Cardiovascular Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Xukun","family":"Bi","sequence":"first","affiliation":[{"name":"Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nursing, No. 906 Hospital of People\u2019s Liberation Army, Ningbo 315000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangjun","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Writing Committee Members, Virani, S.S., Newby, L.K., Arnold, S.V., Bittner, V., Brewer, L.C., Demeter, S.H., Dixon, D.L., Fearon, W.F., and Hess, B. 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