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In this retrospective multicenter study, machine learning (ML) methods were employed to investigate the relationship between metabolic profile and prognosis at diagnosis in a total of 219 HCC patients. The eXtreme Gradient Boosting (XGB) method demonstrated superiority in identifying mortality predictors in our patients. Etiology was the most determining prognostic factor followed by Barcelona Clinic Liver Cancer (BCLC) and Eastern Cooperative Oncology Group (ECOG) classifications. Variables related to the development of hepatic steatosis and metabolic syndrome, such as elevated levels of alkaline phosphatase (ALP), uric acid, obesity, alcohol consumption, and high blood pressure (HBP), had a significant impact on mortality prediction. This study underscores the importance of metabolic syndrome as a determining factor in the progression of HCC secondary to MASLD. The use of ML techniques provides an effective tool to improve risk stratification and individualized therapeutic management in these patients.<\/jats:p>","DOI":"10.3390\/metabo14060305","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T03:48:49Z","timestamp":1716868129000},"page":"305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic Impact of Metabolic Syndrome and Steatotic Liver Disease in Hepatocellular Carcinoma Using Machine Learning Techniques"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-3467","authenticated-orcid":false,"given":"Sergio","family":"Gil-Rojas","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Virgen de la Luz Hospital, 16002 Cuenca, Spain"},{"name":"Medical Analysis Expert Group, Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain"},{"name":"Medical Analysis Expert Group, Institute of Technology, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-7449","authenticated-orcid":false,"given":"Miguel","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Virgen de la Luz Hospital, 16002 Cuenca, Spain"},{"name":"Medical Analysis Expert Group, Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain"},{"name":"Medical Analysis Expert Group, Institute of Technology, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5807-9653","authenticated-orcid":false,"given":"Pablo","family":"Mart\u00ednez-Blanco","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Virgen de la Luz Hospital, 16002 Cuenca, Spain"},{"name":"Medical Analysis Expert Group, Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain"},{"name":"Medical Analysis Expert Group, Institute of Technology, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Torres","sequence":"additional","affiliation":[{"name":"Medical Analysis Expert Group, Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain"},{"name":"Medical Analysis Expert Group, Institute of Technology, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3380-639X","authenticated-orcid":false,"given":"Natalia","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, University Hospital of Guadalajara, 19002 Guadalajara, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Blasco","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, General University Hospital, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-7405","authenticated-orcid":false,"given":"Miguel","family":"Torralba","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, University Hospital of Guadalajara, 19002 Guadalajara, Spain"},{"name":"Faculty of Medicine, Universidad de Alcal\u00e1 de Henares, 28801 Alcal\u00e1 de Henares, Spain"},{"name":"Translational Research Group in Cellular Immunology (GITIC), Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mateo","sequence":"additional","affiliation":[{"name":"Medical Analysis Expert Group, Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain"},{"name":"Medical Analysis Expert Group, Institute of Technology, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15330338231219434","DOI":"10.1177\/15330338231219434","article-title":"Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma","volume":"22","author":"Bhat","year":"2023","journal-title":"Technol. 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