{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:27:54Z","timestamp":1760146074019,"version":"build-2065373602"},"reference-count":65,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["31901808","31972111","IDHT20180506"],"award-info":[{"award-number":["31901808","31972111","IDHT20180506"]}]},{"name":"Project of High-Level Teacher in Beijing Municipal Universities","award":["31901808","31972111","IDHT20180506"],"award-info":[{"award-number":["31901808","31972111","IDHT20180506"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolites"],"abstract":"<jats:p>Background: Pentosidine is an advanced glycation end product that is commonly found in heat-processed foods. Pentosidine has been involved in the occurrence and development of some chronic diseases. It was reported that pentosidine exposure can impair the function of the liver and kidneys. Adipose tissue, as an active endocrine organ, plays an important role in maintaining the normal physiological function of cells. However, the metabolic mechanism that causes pentosidine to induce toxicity in adipose tissue remains unclear. Methods: In the study, thirty male Sprague-Dawley rats were divided into a normal diet group, low dose group, and high dose group. A non-targeted metabolomics approach was used to compare the metabolic profiles of adipose tissue between the pentosidine and normal diet groups. Furthermore, histopathological observation and body weight change analysis were performed to test the results of the metabolomics analysis. Results: A total of forty-two differential metabolites were identified. Pentosidine mainly disturbed twelve metabolic pathways, such as ascorbate and aldarate metabolism, glycine, serine, and threonine metabolism, sulfur metabolism, pyruvate metabolism, etc. Additionally, pyruvic acid was identified as a possible key upregulated metabolite involved in thirty-four metabolic pathways. \u03b1-Ketoglutaric acid was named as a probable key downregulated metabolite involved in nineteen metabolic pathways based on enrichment network analysis. In addition, histopathological analysis and body weight changes confirmed the results of the metabolomics analysis. Conclusions: These results provided a new perspective for the molecular mechanisms of adipose tissue toxicity induced by pentosidine.<\/jats:p>","DOI":"10.3390\/metabo14100539","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T07:39:52Z","timestamp":1728459592000},"page":"539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Untargeted Metabolite Profiling Reveals Acute Toxicity of Pentosidine on Adipose Tissue of Rats"],"prefix":"10.3390","volume":"14","author":[{"given":"Chuanqin","family":"Hu","sequence":"first","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University (BTBU), 11 Fucheng Road, Beijing 100048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University (BTBU), 11 Fucheng Road, Beijing 100048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University (BTBU), 11 Fucheng Road, Beijing 100048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4896-0142","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1002\/jsfa.8853","article-title":"Review of pentosidine and pyrraline in food and chemical models: Formation, potential risks and determination","volume":"98","author":"Li","year":"2018","journal-title":"J. Sci. Food Agr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"21843","DOI":"10.1021\/jacs.2c09626","article-title":"Pentosinane, a post-translational modification of human proteins with underappreciated stability","volume":"144","author":"Deramon","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.tifs.2021.06.055","article-title":"Formation and fate of Amadori rearrangement products in Maillard reaction","volume":"115","author":"Cui","year":"2021","journal-title":"Trends Food Sci. Tech."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1021\/acs.jafc.8b01466","article-title":"Microbionne-metabolomics analysis of the impacts of long-term dietary advanced-glycation-end-product consumption on C57BL\/6 mouse fecal microbiota and metabolites","volume":"66","author":"Qu","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.foodchem.2008.06.076","article-title":"Analysis of glycative products in sauces and sauce-treated foods","volume":"113","author":"Chao","year":"2009","journal-title":"Food Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.redox.2013.12.016","article-title":"Role of advanced glycation end products in cellular signaling","volume":"2","author":"Ott","year":"2014","journal-title":"Redox Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1046\/j.1523-1755.1998.00756.x","article-title":"Renal catabolism of advanced glycation end products: The fate of pentosidine","volume":"53","author":"Miyata","year":"1998","journal-title":"Kidney Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.ijbiomac.2014.10.034","article-title":"Acquired immunogenicity of calf thymus DNA and LDL modified by b-ribose: A comparative study","volume":"72","author":"Akhter","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Indyk, D., Bronowicka-Szydelko, A., Gamian, A., and Kuzan, A. (2021). Advanced glycation end products and their receptors in serum of patients with type 2 diabetes. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-92630-0"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bbadis.2019.01.006","article-title":"Impact of advanced glycation end products (AGEs) signaling in coronary artery disease","volume":"1865","author":"Kosmopoulos","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11649","DOI":"10.1016\/S0021-9258(18)99006-X","article-title":"Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors","volume":"266","author":"Grandhee","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.foodchem.2010.12.036","article-title":"Determination of carnosine, anserine, homocarnosine, pentosidine and thiobarbituric acid reactive substances contents in meat from different animal species","volume":"126","author":"Peiretti","year":"2011","journal-title":"Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.foodchem.2016.09.039","article-title":"Effect of hydroxytyrosol and olive leaf extract on 1,2-dicarbonyl compounds, hydroxymethylfurfural and advanced glycation endproducts in a biscuit model","volume":"217","author":"Navarro","year":"2017","journal-title":"Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"105984","DOI":"10.1016\/j.envint.2020.105984","article-title":"Serum metabolic changes associated with dioxin exposure in a Chinese male cohort","volume":"143","author":"Liang","year":"2020","journal-title":"Environ. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2200046","DOI":"10.1002\/mnfr.202200046","article-title":"Dietary advanced glycation end-products affects the progression of early diabetes by intervening in carbohydrate and lipid metabolism","volume":"66","author":"Wu","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Hu, C.Q., Song, X.Y., Shao, Z.Z., Liu, Y.L., Wang, J., and Sun, B.G. (2023). Untargeted metabolite profiling of adipose tissue in rats exposed to mepiquat. Foods, 12.","DOI":"10.3390\/foods12040867"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"163592","DOI":"10.1016\/j.scitotenv.2023.163592","article-title":"Xanthine-derived reactive oxygen species exacerbates adipose tissue disorders in male db\/db mice induced by real-ambient PM2.5 exposure","volume":"882","author":"Chen","year":"2023","journal-title":"Sci. Total. Environ."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s00018-023-05050-w","article-title":"Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation","volume":"81","author":"Jiang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tcb.2021.10.008","article-title":"Mitochondrial regulation and white adipose tissue homeostasis","volume":"32","author":"Zhu","year":"2022","journal-title":"Trends Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jes.2024.03.001","article-title":"T-2 toxin induces cardiac fibrosis by causing metabolic disorders and up-regulating Sirt3\/FoxO3\u03b1\/MnSOD signaling pathway-mediated oxidative stress","volume":"150","author":"Qiao","year":"2025","journal-title":"J. Environ. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Liang, H., and Song, K. (2024). Elucidating ascorbate and aldarate metabolism pathway characteristics via integration of untargeted metabolomics and transcriptomics of the kidney of high-fat diet-fed obese mice. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0300705"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41392-023-01569-3","article-title":"Amino acid metabolism in health and disease","volume":"8","author":"Ling","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Chu, C., Liu, S.Q., Nie, L.G., Hu, H.M., Liu, Y., and Yang, J. (2024). The interactions and biological pathways among metabolomics prod-ucts of patients with coronary heart disease. Biomed. Pharmacother., 173.","DOI":"10.1016\/j.biopha.2024.116305"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1021\/acs.jafc.0c06445","article-title":"The effect of exogenous free N\u03b5-(Carboxymethyl)Lysine on diabetic-model Goto-Kakizaki rats: Metabolomics analysis in serum and urine","volume":"69","author":"Quan","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1021\/acs.jafc.0c01023","article-title":"Threonine, but not lysine and methionine, reduces fat accumulation by regulating lipid metabolism in obese mice","volume":"68","author":"Ma","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cmet.2020.03.012","article-title":"NADH ties one-carbon metabolism to cellular respiration","volume":"31","author":"Maynard","year":"2020","journal-title":"Cell Metab."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Holecek, M. (2022). Serine metabolism in health and disease and as a conditionally essential amino acid. Nutrients, 14.","DOI":"10.3390\/nu14091987"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s12276-020-00504-8","article-title":"Glutamine reliance in cell metabolism","volume":"52","author":"Yoo","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/s42255-024-01084-x","article-title":"Adipose glutaminolysis resurfaces in metabolic disease","volume":"6","author":"Haley","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbrc.2022.03.010","article-title":"\u03b1-ketoisocaproic acid promotes ER stress through impairment of autophagy, thereby provoking lipid accumulation and insulin resistance in murine preadipocytes","volume":"603","author":"Park","year":"2022","journal-title":"Biochem. Bioph. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1039\/C9FO03084K","article-title":"Leucine and isoleucine have similar effects on reducing lipid accumulation, improving insulin sensitivity and increasing the browning of WAT in high-fat diet-induced obese mice","volume":"11","author":"Ma","year":"2020","journal-title":"Food Funct."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kuang, W.Y., Yang, J.J., Liu, Z.Y., Zeng, J.Z., Xia, X.W., Chen, X.D., Zhong, S.Y., and Huang, R.M. (2022). Catechin mediates ferroptosis to exert an anti-inflammatory effect on RAW 264.7 cells. Foods, 11.","DOI":"10.3390\/foods11111572"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s10020-024-00905-9","article-title":"Advanced glycation end products and reactive oxygen species: Uncovering the potential role of ferroptosis in diabetic complications","volume":"30","author":"Chen","year":"2024","journal-title":"Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1080\/10408398.2015.1087964","article-title":"Benzoic acid and its derivatives as naturally occurring compounds in foods and as additives: Uses, exposure, and controversy","volume":"57","author":"Calzada","year":"2017","journal-title":"Crit. Rev. Food Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"106521","DOI":"10.1016\/j.aquatox.2023.106521","article-title":"Integrated physiological and metabolomic analysis reveals new insights into toxicity pathways of paraquat to Microcystis aeruginosa","volume":"259","author":"Bai","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1126\/science.adh2771","article-title":"Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis","volume":"383","author":"Sahu","year":"2024","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nature15529","article-title":"Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis","volume":"527","author":"Rabinovich","year":"2015","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1002\/ptr.7575","article-title":"Quercetin improves high-fat diet-induced obesity by modulating gut micro-biota and metabolites in C57BL\/6J mice","volume":"36","author":"Su","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41586-022-04475-w","article-title":"A non-canonical tricarboxylic acid cycle underlies cellular identity","volume":"603","author":"Arnold","year":"2022","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-023-05770-w","article-title":"Fumarate induces vesicular release of mtDNA to drive innate immunity","volume":"615","author":"Zecchini","year":"2023","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/alz.12786","article-title":"Plasma metabolites associated with cognitive function across race\/ethnicities affirming the importance of healthy nutrition","volume":"19","author":"He","year":"2023","journal-title":"Alzheimers Dement."},{"key":"ref_42","first-page":"849","article-title":"Lysosomal regulation of extracellular vesicle excretion during D-ribose-induced NLRP3 inflammasome activation in podocytes","volume":"1866","author":"Hong","year":"2019","journal-title":"BBA-Mol. Cell Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"739910","DOI":"10.1016\/j.aquaculture.2023.739910","article-title":"Dietary inositol improved glucose and lipid metabolism mediated by the Insulin-PI3K-Akt signaling pathway in Pacific white shrimp (Litopenaeus vannamei)","volume":"577","author":"Lu","year":"2023","journal-title":"Aquaculture"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"122433","DOI":"10.1016\/j.envpol.2023.122433","article-title":"Continuous exposure to bisphenol S increases the accumulation of endogenous metabolic toxicants by obstructing the glucuronic acid pathway","volume":"336","author":"Li","year":"2023","journal-title":"Environ. Pollut."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.matbio.2018.02.012","article-title":"Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism","volume":"78\u201379","author":"Zhu","year":"2019","journal-title":"Matrix Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2023.0306","article-title":"Malaria is associated with diminished levels of ascorbic acid: A systematic review and meta-analysis. Antioxid","volume":"40","author":"Kotepui","year":"2024","journal-title":"Redox Sign."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"101706","DOI":"10.1016\/j.arr.2022.101706","article-title":"Short-chain fatty acid metabolism and multiple effects on cardi-ovascular diseases","volume":"81","author":"Hu","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E501","DOI":"10.1017\/S0029665120004498","article-title":"Propionic acid intervention in obese Ldlr-\/-.Leiden mice attenuates NASH development, but negatively affects cognition","volume":"79","author":"Gart","year":"2020","journal-title":"Proc. Nutr. Soc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1136\/gutjnl-2017-314050","article-title":"Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit","volume":"67","author":"Li","year":"2018","journal-title":"Gut"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1021\/acs.jafc.3c08926","article-title":"Butyrate alleviates high-fat-induced metabolic disorders partially through increasing systematic glutamine","volume":"72","author":"Fan","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1002\/ptr.7965","article-title":"Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases","volume":"37","author":"Liu","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e202104342","DOI":"10.1002\/chem.202104342","article-title":"Cross-talk between (hydrogen)sulfite and metalloproteins: Impact on human health","volume":"28","author":"Maiti","year":"2022","journal-title":"Chem.-Eur. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s42255-021-00493-6","article-title":"Lipolysis: Cellular mechanisms for lipid mobilization from fat stores","volume":"3","author":"Grabner","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e13724","DOI":"10.1111\/obr.13724","article-title":"Inflammation-mediated metabolic regulation in adipose tissue","volume":"25","author":"Xu","year":"2024","journal-title":"Obes. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.chembiol.2017.04.009","article-title":"The mammalian malonyl-CoA synthetase ACSF3 is required for mitochondrial protein malonylation and metabolic efficiency","volume":"24","author":"Bowman","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tem.2021.03.002","article-title":"Role of medium-chain fatty acids in healthy metabolism: A clinical perspective","volume":"32","author":"Huang","year":"2021","journal-title":"Trends Endocrinol. Met."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.molmet.2020.01.002","article-title":"A neural basis for octanoic acid regulation of energy balance","volume":"34","author":"Haynes","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2200582","DOI":"10.1002\/mnfr.202200582","article-title":"Potentiation of lipotoxicity in human EndoC-\u03b2H1 \u03b2-Cells by glucose is dependent on the structure of free fatty acids","volume":"67","author":"Tsikas","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature14601","article-title":"Regulation of mitochondrial morphology and function by stearoylation of TFR1","volume":"525","author":"Senyilmaz","year":"2015","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7347","DOI":"10.1039\/D3FO01403G","article-title":"Astaxanthin reduces fat storage in a fat-6\/fat-7 dependent manner determined using high fat Caenorhabditis elegans","volume":"14","author":"Xie","year":"2023","journal-title":"Food Funct."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"150350","DOI":"10.1016\/j.scitotenv.2021.150350","article-title":"Lipid metabolism dysfunction and toxicity of BDE-47 exposure in white adipose tissue revealed by the integration of lipidomics and metabolomics","volume":"806","author":"Yang","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Alonso-Castro, A.J., Serrano-Vega, R., Guti\u00e9rrez, S.P., Isiordia-Espinoza, M.A., and Solorio-Alvarado, C.R. (2022). Myristic acid reduces skin inflammation and nociception. J. Food Biochem., 46.","DOI":"10.1111\/jfbc.14013"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-nutr-122319-034142","article-title":"Omega-3 fatty acids and adipose tissue: Inflammation and browning","volume":"40","author":"Kalupahana","year":"2020","journal-title":"Annu. Rev. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Dakroub, H., Nowak, M., Benoist, J.F., No\u00ebl, B., Vedie, B., Paul, J.L., and Fournier, N. (2021). Eicosapentaenoic acid membrane incorpo-ration stimulates ABCA1-mediated cholesterol efflux from human THP-1 macrophages. Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1866.","DOI":"10.1016\/j.bbalip.2021.159016"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"360","DOI":"10.26599\/FSHW.2022.9250030","article-title":"Inhibitory effect of procyanidin B2 and tannin acid on cholesterol esterase and their synergistic effect with orlistat","volume":"13","author":"Li","year":"2024","journal-title":"Food Sci. Hum. Well."}],"container-title":["Metabolites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-1989\/14\/10\/539\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:09:37Z","timestamp":1760112577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-1989\/14\/10\/539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":65,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["metabo14100539"],"URL":"https:\/\/doi.org\/10.3390\/metabo14100539","relation":{},"ISSN":["2218-1989"],"issn-type":[{"type":"electronic","value":"2218-1989"}],"subject":[],"published":{"date-parts":[[2024,10,9]]}}}