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Int., 2017.","DOI":"10.1155\/2017\/4391920"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Shan, H., Luo, R., Guo, X., Li, R., Ye, Z., Peng, T., Liu, F., and Yang, Z. (2022). Abnormal Endometrial Receptivity and Oxidative Stress in Polycystic Ovary Syndrome. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.904942"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijcard.2015.08.087","article-title":"The treatment of hyperuricemia","volume":"213","author":"Gliozzi","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Sharma, R., Biedenharn, K.R., Fedor, J.M., and Agarwal, A. (2013). Lifestyle factors and reproductive health: Taking control of your fertility. Reprod. Biol. 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